IL5 signaling (WP127)

Homo sapiens

Interleukin 5 (IL-5) ligand belongs to the cytokine superfamily. IL-5 is a glycoprotein which belongs to the cytokine superfamily. It possesses the four helical bundle motifs that is conserved among several hematopoietic cytokines. IL-5 plays an important role in the proliferation and differentiation of eosinophils. IL-5 induces terminal maturation of eosinophils, prolongs eosinophils survival by delaying apoptotic death, increases eosinophils adhesion to endothelial cells and enhances eosinophils effector function. IL-5 plays important roles in the pathogenesis of asthma, hypereosinophilic syndromes and eosinophil-dependent inflammatory diseases. IL-5 is produced by eosinophils, mast cells, Th2 cells, Tc2 cells and gamma delta T cells. IL-5 exerts influence on different biological activities by associating with the IL-5 receptor. This receptor is a heterodimeric complex consisting of an alpha chain-IL5RA and a beta chain, CSF2RB, which is shared between IL-5 receptor, IL-3 receptor and granulocyte macrophage colony stimulating factor receptor. Binding of IL-5 to the receptor complex results in the recruitment of adapter proteins including SHC1, GRB2 and SOS1. This leads to the activation of the Ras/Raf/MEK/ERK cascade. Subsequent activation of transcription factors including JUN and ELK-1 regulates the expression of genes involved in the control of cell growth and differentiation. IL-5 stimulation also resulted in the activation of PI3K/AKT/RPS6K pathway resulting in the phosphorylation of RPS6 and regulation of gene expression. JAK phosphorylation and activation is also brought about by IL-5, which in turn results in the activation and nuclear translocation of STAT proteins. The STAT transcription factors are responsible for the expression of early response genes and feedback inhibitor of JAK/STAT pathway. In addition, IL-5 is known to activate various tyrosine kinases such as LYN, BTK and SYK. The interactions and intersections between canonical and non-canonical IL-5 signaling systems are depicted in the pathway map. Please access this pathway at [http://www.netpath.org/netslim/IL_5_pathway.html NetSlim] database. If you use this pathway, please cite the following paper: Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Authors

Akhilesh Pandey , Kristina Hanspers , Martijn Van Iersel , Alex Pico , NetPath , Andra Waagmeester , Christine Chichester , Noopur Sinha , Lauren J. Dupuis , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

interleukin-5 signaling pathway Interleukin mediated signaling pathway

Participants

Label Type Compact URI Comment
PIK3CG GeneProduct ncbigene:5294
STAT5B Protein ncbigene:6777
STAT5A Protein ncbigene:6776
RPS6KB1 Protein ncbigene:6198
MAPK3 Protein ncbigene:5595
AKT1 Protein ncbigene:207
HRAS Protein ncbigene:3845
PIK3R2 Protein ncbigene:5296
BTK Protein ncbigene:695
PIK3R1 Protein ncbigene:5295
RPS6KA1 Protein ncbigene:6195
JAK1 Protein ncbigene:3716
GSK3A Protein ncbigene:2931
GSK3B Protein ncbigene:2932
JAK2 Protein ncbigene:3717
LYN Protein ncbigene:4067
SPRED1 Protein ncbigene:161742
PTPN11 Protein ncbigene:5781
ELK1 Protein ncbigene:2002
MAP2K2 Protein ncbigene:5605
SHC1 Protein ncbigene:6464
IL5 Protein ncbigene:3558
IL5 Protein ncbigene:3558
STAT5B Protein ncbigene:6777
RPS6 Protein ncbigene:6194
JUN Protein ncbigene:3725
MTOR Protein ncbigene:4137
SOS1 Protein ncbigene:6654
RAF1 Protein ncbigene:5894
MAP2K1 Protein ncbigene:5604
IL5RA Protein ncbigene:3568
IL5RA Protein ncbigene:3568
CSF2RB Protein ncbigene:1439
CSF2RB Protein ncbigene:1439
STAT3 Protein ncbigene:6774
MAPK1 Protein ncbigene:5594
FOXO3A Protein ncbigene:2309
STAT1 Protein ncbigene:6772
GRB2 Protein ncbigene:2885
RPS6KB2 Protein ncbigene:6199
STAT5A Protein ncbigene:6776
SYK Protein ncbigene:6850

References

  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia