Arylamine metabolism (WP694)

Homo sapiens

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Simplified scheme of arylamine metabolism pathway. Arylamines are N-acetylated by NAT2 in the liver, transforming them to relatively nonreactive. Alternatively, they may be N-hydroxylated by CYPIA2, trans - ported to the bladder, and undergo O-acetylation by NATI, to form a highly reactive species. [https://www.researchgate.net/figure/Simplified-scheme-of-arylamine-metabolism-pathway-Arylamines-are-N-acetylated-by-NAT2-in_fig2_288003735]

Authors

Pieter Giesbertz , Stan Gaj , Chris Evelo , Kristina Hanspers , Martijn Van Iersel , Christine Chichester , Martina Summer-Kutmon , Denise Slenter , Asios Olia , and Egon Willighagen

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

metabolic pathway of secondary metabolites arylamine metabolic pathway

Participants
Query Drugst.One

Label Type Compact Identifier Comment
N-Acetylarylamine Metabolite hmdb:HMDB0001250
Acetyl-CoA Metabolite hmdb:HMDB0001206
Arylamine Metabolite chebi:50471
an N-hydroxyarylamine Metabolite chebi:13792
Coenzyme A Metabolite hmdb:HMDB0001423
UGT1A9 GeneProduct ncbigene:54600
UGT1A4 GeneProduct ncbigene:54657
CYP1A2 GeneProduct ensembl:ENSG00000140505
NAT1 GeneProduct ensembl:ENSG00000171428
SULT1A2 GeneProduct ensembl:ENSG00000197165
NAT1 GeneProduct ensembl:ENSG00000171428
NAT2 GeneProduct ensembl:ENSG00000156006
SULT1A1 GeneProduct ensembl:ENSG00000196502
NAT2 GeneProduct ensembl:ENSG00000156006

References

  1. Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s). Chou HC, Lang NP, Kadlubar FF. Cancer Res. 1995 Feb 1;55(3):525–9. PubMed Europe PMC Scholia
  2. Polymorphism of human acetyltransferases. Meyer UA. Environ Health Perspect. 1994 Oct;102 Suppl 6(Suppl 6):213–6. PubMed Europe PMC Scholia
  3. Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery. Sim E, Abuhammad A, Ryan A. Br J Pharmacol. 2014 Jun;171(11):2705–25. PubMed Europe PMC Scholia