Focal adhesion (WP85)

Mus musculus

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Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signaling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signaling.

Authors

Kristina Hanspers , Christine Chichester , Egon Willighagen , Jonathan Mélius , Lauren J. Dupuis , Nhung Pham , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

cell adhesion signaling pathway

Participants

Label Type Compact URI Comment
Col4a1 GeneProduct ncbigene:12826
Tesk2 GeneProduct ncbigene:230661
Actg1 GeneProduct ncbigene:11465
Pdpk1 GeneProduct ncbigene:18607
Rac2 GeneProduct ncbigene:19354
Gsk3b GeneProduct ncbigene:56637
Mylk GeneProduct ncbigene:107589
Col5a3 GeneProduct ncbigene:53867
Thbs4 GeneProduct ncbigene:21828
Txk GeneProduct ncbigene:22165
Fyn GeneProduct ncbigene:14360 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
Sos1 GeneProduct ncbigene:20662 SOS1; son of sevenless homolog 1 (Drosophila)
Col5a1 GeneProduct ncbigene:12831
Itgb6 GeneProduct ncbigene:16420
Pelo GeneProduct ncbigene:105083
Rap1a GeneProduct ncbigene:109905 RAP1A; RAP1A member of RAS oncogene family
Cav3 GeneProduct ncbigene:12391 CAV3; caveolin 3
Bad GeneProduct ncbigene:12015
Itga11 GeneProduct ncbigene:319480
Rac3 GeneProduct ncbigene:170758
Col11a2 GeneProduct ncbigene:12815
Lamb3 GeneProduct ncbigene:16780
Sepp1 GeneProduct ncbigene:20363 SEPP1; selenoprotein P plasma
Grb2 GeneProduct ncbigene:14784 GRB2; growth factor receptor-bound protein 2
Tnn GeneProduct ncbigene:329278
Bcl2 GeneProduct ncbigene:12043
Raf1 GeneProduct mgi:MGI:97847 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
Farp2 GeneProduct ncbigene:227377
Capn1 GeneProduct ncbigene:12333
Hgf GeneProduct ncbigene:15234
Met GeneProduct ncbigene:17295
Egfr GeneProduct ncbigene:13649
Rhoa GeneProduct ncbigene:11848
Itga7 GeneProduct ncbigene:16404
Itgam GeneProduct ncbigene:16409
Col1a2 GeneProduct ncbigene:12843
Mapk9 GeneProduct ncbigene:26420
Pik3r5 GeneProduct ncbigene:320207
Ibsp GeneProduct ncbigene:15891
Pak1 GeneProduct ncbigene:18479
Col5a2 GeneProduct ncbigene:12832
Srms GeneProduct ncbigene:20811
Ilk GeneProduct ncbigene:16202 ILK; integrin-linked kinase [EC:2.7.1.-]
Col4a6 GeneProduct ncbigene:94216
Mylk2 GeneProduct ncbigene:228785
Pak3 GeneProduct ncbigene:18481
Thbs3 GeneProduct ncbigene:21827
Itga2 GeneProduct ncbigene:16398
Birc3 GeneProduct ncbigene:11796
Lama2 GeneProduct ncbigene:16773
Rapgef1 GeneProduct ncbigene:107746
Pip5k1c GeneProduct ncbigene:18717
Col2a1 GeneProduct ncbigene:12824
Col4a4 GeneProduct ncbigene:12829
Mapk6 GeneProduct ncbigene:50772 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
Egf GeneProduct ncbigene:13645
Itgb4 GeneProduct ncbigene:192897
Itga5 GeneProduct ncbigene:16402
Birc2 GeneProduct ncbigene:11797
Lama4 GeneProduct ncbigene:16775
Itgb8 GeneProduct ncbigene:320910
Itgad GeneProduct ncbigene:381924
Itgb3 GeneProduct ncbigene:16416
Rock2 GeneProduct ncbigene:19878
Lama5 GeneProduct ncbigene:16776
Styk1 GeneProduct ncbigene:243659
Dock1 GeneProduct mgi:MGI:2429765 DOCK1; dedicator of cyto-kinesis
Chad GeneProduct ncbigene:12643
Shc3 GeneProduct ncbigene:20418 SHC3; neuronal Sh
Itga10 GeneProduct ensembl:ENSMUSG00000090210
Araf GeneProduct ncbigene:11836 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
Crk GeneProduct ncbigene:12928
Map2k2 GeneProduct ncbigene:26396 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
Map2k3 GeneProduct ncbigene:26397 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
Tnxb GeneProduct ncbigene:81877
Parvb GeneProduct ncbigene:170736
Pik3cg GeneProduct ncbigene:30955
Itga3 GeneProduct ncbigene:16400
Col1a1 GeneProduct ncbigene:12842
Itga6 GeneProduct ncbigene:16403
Figf GeneProduct ncbigene:14205
Braf GeneProduct ncbigene:109880 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
Flna GeneProduct ncbigene:192176
Mapk1 GeneProduct ncbigene:26413 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
Ccnd2 GeneProduct ncbigene:12444
Pdgfd GeneProduct ncbigene:71785
Diap1 GeneProduct ncbigene:13367
Ppp1r12a GeneProduct ncbigene:17931
Itgav GeneProduct mgi:MGI:96608
Ptk2 GeneProduct ncbigene:14083 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
Vcl GeneProduct ncbigene:22330 VCL; vinculin
Lama1 GeneProduct ncbigene:16772
Vwf GeneProduct ncbigene:22371
Col3a1 GeneProduct ncbigene:12825
Vav1 GeneProduct ncbigene:22324
Akt3 GeneProduct ncbigene:23797
Itgax GeneProduct ncbigene:16411
Pak7 GeneProduct ncbigene:241656
Tnk2 GeneProduct ncbigene:51789
Itgb2 GeneProduct ncbigene:16414
Pdgfra GeneProduct ncbigene:18595
Ccnd3 GeneProduct ncbigene:12445
Pdgfc GeneProduct ncbigene:54635
Map2k5 GeneProduct ncbigene:23938 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
Itga2b GeneProduct ncbigene:16399
Rap1b GeneProduct ncbigene:215449 RAP1B; RAP1B member of RAS oncogene family
Blk GeneProduct ncbigene:12143
Flt1 GeneProduct ncbigene:14254
Mapk8 GeneProduct ncbigene:26419
Rac1 GeneProduct ncbigene:19353
Lamc3 GeneProduct ncbigene:23928
Rock1 GeneProduct ncbigene:19877
Ptk6 GeneProduct ncbigene:20459
Thbs2 GeneProduct ncbigene:21826
Cdc42 GeneProduct ncbigene:12540
Itgb7 GeneProduct ncbigene:16421
Zyx GeneProduct ncbigene:22793 ZYX; zyxin
Src GeneProduct ncbigene:20779 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
Pak2 GeneProduct ncbigene:224105
Pdgfb GeneProduct ncbigene:18591
Tnk1 GeneProduct ncbigene:83813
Spp1 GeneProduct ncbigene:20750
Map2k6 GeneProduct ncbigene:26399 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
Pak6 GeneProduct ncbigene:214230
Mapk4 GeneProduct ncbigene:225724 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
Crk1 GeneProduct ncbigene:12929
Fn1 GeneProduct ncbigene:14268
Arhgap5 GeneProduct ncbigene:11855
Col11a1 GeneProduct ncbigene:12814
Itga4 GeneProduct ncbigene:16401
Cav2 GeneProduct ncbigene:12390 CAV2; caveolin 2
Cav GeneProduct ncbigene:12389 CAV1; caveolin 1 caveolae protein 22kD
Vtn GeneProduct ncbigene:22370
Igf1 GeneProduct ncbigene:16000
Shc1 GeneProduct ncbigene:20416 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
Actn1 GeneProduct ncbigene:109711
Pgf GeneProduct ncbigene:18654
Pak4 GeneProduct ncbigene:70584
Rhob GeneProduct ncbigene:11852
Pdgfa GeneProduct ncbigene:18590
Mapk7 GeneProduct ncbigene:23939 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
Akt1 GeneProduct ncbigene:11651
Pxn GeneProduct ncbigene:19303
Pik3cb GeneProduct ncbigene:74769
Pik3cd GeneProduct ncbigene:18707
Erbb2 GeneProduct ncbigene:13866
Pdgfrb GeneProduct ncbigene:18596
Braf GeneProduct ncbigene:109880
Map2k1 GeneProduct ncbigene:26395 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
Lamc1 GeneProduct ncbigene:226519
Ccnd1 GeneProduct ncbigene:12443
Lamb2 GeneProduct ncbigene:16779
Vegfb GeneProduct ncbigene:22340
Tln1 GeneProduct ncbigene:21894
Pik3ca GeneProduct ncbigene:18706
Lama3 GeneProduct ensembl:ENSMUSG00000024421
Hck GeneProduct ncbigene:15162
Pten GeneProduct ncbigene:19211
Vegfc GeneProduct ncbigene:22341
Lamb1-1 GeneProduct ncbigene:16777
Elk1 GeneProduct ncbigene:13712
Reln GeneProduct ncbigene:19699
Pik3r4 GeneProduct ncbigene:75669
Col4a2 GeneProduct ncbigene:12827
Actb GeneProduct ncbigene:11461
Itgb1 GeneProduct ncbigene:16412
Itga8 GeneProduct ncbigene:241226
Itgae GeneProduct ncbigene:16407
Itga9 GeneProduct ncbigene:104099
Vegfa GeneProduct ncbigene:22339
Col6a2 GeneProduct ncbigene:12834
Itgb5 GeneProduct ncbigene:16419
Thbs1 GeneProduct ncbigene:21825
Itgal GeneProduct ncbigene:16408
Bcar1 GeneProduct ncbigene:12927
Akt2 GeneProduct ncbigene:11652
Pik3r1 GeneProduct ncbigene:18708
Pik3r2 GeneProduct ncbigene:18709
Lamc2 GeneProduct ncbigene:16782
Vasp GeneProduct ncbigene:22323 VASP; vasodilator-stimulated phosphoprotein
Tnc GeneProduct ncbigene:21923
Myl6 GeneProduct ncbigene:17904
Jun GeneProduct ncbigene:16476
Mapk12 GeneProduct ncbigene:29857 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
Fgr GeneProduct ncbigene:14191
Tnr GeneProduct ncbigene:21960

References

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