NOTCH1 regulation of endothelial cell calcification (WP3413)
Homo sapiens
Model of NOTCH1 regulation of human endothelial cell calcification. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3413 CPTAC Assay Portal]
Authors
Kristina Hanspers , Elisa Cirillo , and Eric WeitzActivity
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Cited In
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| NOTCH1 | GeneProduct | ensembl:ENSG00000148400 | |
| PAR1 | GeneProduct | ensembl:ENSG00000198121 | |
| SOX6 | GeneProduct | ensembl:ENSG00000110693 | |
| ALPL | GeneProduct | ensembl:ENSG00000162551 | |
| SAT1 | GeneProduct | ensembl:ENSG00000130066 | |
| CALU | GeneProduct | ensembl:ENSG00000128595 | |
| FGFR3 | GeneProduct | ensembl:ENSG00000068078 | |
| ITGA1 | GeneProduct | ensembl:ENSG00000213949 | |
| GJA5 | GeneProduct | ncbigene:2702 | |
| VEGF | GeneProduct | ensembl:ENSG00000112715 | |
| DLL1 | GeneProduct | ensembl:ENSG00000198719 | |
| DLL3 | GeneProduct | ensembl:ENSG00000090932 | |
| DLL4 | GeneProduct | ensembl:ENSG00000128917 | |
| JAG1 | GeneProduct | ensembl:ENSG00000101384 | |
| JAG2 | GeneProduct | ensembl:ENSG00000184916 | |
| MGP | Protein | ensembl:ENSG00000111341 | |
| PLAT | Protein | ensembl:ENSG00000104368 | |
| PTHrP | Protein | ensembl:ENSG00000104368 |
References
- NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, et al. J Mol Cell Cardiol. 2015 Jul;84:13–23. PubMed Europe PMC Scholia