NOTCH1 regulation of endothelial cell calcification (WP3413)

Homo sapiens

Model of NOTCH1 regulation of human endothelial cell calcification. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Kristina Hanspers , Elisa Cirillo , and Eric Weitz


last edited

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Homo sapiens



Pathway Ontology

regulatory pathway


Label Type Compact URI Comment
NOTCH1 GeneProduct ensembl:ENSG00000148400
PAR1 GeneProduct ensembl:ENSG00000198121
SOX6 GeneProduct ensembl:ENSG00000110693
ALPL GeneProduct ensembl:ENSG00000162551
SAT1 GeneProduct ensembl:ENSG00000130066
CALU GeneProduct ensembl:ENSG00000128595
FGFR3 GeneProduct ensembl:ENSG00000068078
ITGA1 GeneProduct ensembl:ENSG00000213949
GJA5 GeneProduct ncbigene:2702
VEGF GeneProduct ensembl:ENSG00000112715
DLL1 GeneProduct ensembl:ENSG00000198719
DLL3 GeneProduct ensembl:ENSG00000090932
DLL4 GeneProduct ensembl:ENSG00000128917
JAG1 GeneProduct ensembl:ENSG00000101384
JAG2 GeneProduct ensembl:ENSG00000184916
MGP Protein ensembl:ENSG00000111341
PLAT Protein ensembl:ENSG00000104368
PTHrP Protein ensembl:ENSG00000104368


  1. NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, et al. J Mol Cell Cardiol. 2015 Jul;84:13–23. PubMed Europe PMC Scholia