Disruption of postsynaptic signaling by CNV (WP4875)
This pathway describes the disruption of postsynaptic signaling due to missing genes caused by copy number variations (CNVs).
AuthorsFriederike Ehrhart , Egon Willighagen , Marvin Martens , and Eric Weitz
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Cell Type Ontologyneuron
Disease Ontologyschizophrenia autism spectrum disorder
Pathway Ontologysignaling pathway
- De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Kirov G, Pocklington AJ, Holmans P, Ivanov D, Ikeda M, Ruderfer D, et al. Mol Psychiatry. 2012 Feb;17(2):142–53. PubMed Europe PMC Scholia