Translation factors (WP107)

Homo sapiens

Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. This pathway gives an overview of the translation factors involved in this process. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal].


Kdahlquist , Martijn Van Iersel , Kristina Hanspers , Michiel Adriaens , Martina Summer-Kutmon , Eric Weitz , and Egon Willighagen


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Homo sapiens



Pathway Ontology

translation pathway


Label Type Compact URI Comment
EIF2AK1 GeneProduct ncbigene:27102
ETF1 GeneProduct ncbigene:2107
EIF4EBP1 GeneProduct ncbigene:1978
EIF2B3 GeneProduct ncbigene:8891
GSPT2 GeneProduct ncbigene:23708
SUI1 GeneProduct ncbigene:10209
EEF1A1 GeneProduct ncbigene:1915
PAIP1 GeneProduct ncbigene:10605
EIF1AY GeneProduct ncbigene:9086
EIF4A1 GeneProduct ncbigene:1973
EIF3S9 GeneProduct ncbigene:8662
EIF4G3 GeneProduct ncbigene:8672
EIF3S3 GeneProduct ncbigene:8667
EIF5 GeneProduct ncbigene:1983
KIAA0664 GeneProduct ncbigene:23277
EIF2S2 GeneProduct ncbigene:8894
EIF4B GeneProduct ncbigene:1975
WBSCR1 GeneProduct ncbigene:7458
EIF2S3 GeneProduct ncbigene:1968
EIF2B4 GeneProduct ncbigene:8890
EIF4EBP2 GeneProduct ncbigene:1979
ITGB4BP GeneProduct ncbigene:3692
EIF3S2 GeneProduct ncbigene:8668
EIF2AK2 GeneProduct ncbigene:5610 now E2K2 HUMAN
EIF2B1 GeneProduct ncbigene:1967
EIF4G1 GeneProduct ncbigene:1981 TrEMBL accession number O43177 refers to same protein.
EIF5B GeneProduct ncbigene:9669
EEF1B2 GeneProduct ncbigene:1933
EEF1A2 GeneProduct ncbigene:1917
PABPC1 GeneProduct ncbigene:26986
SUI1 GeneProduct ncbigene:10209
EIF3S4 GeneProduct ncbigene:8666
EIF3S7 GeneProduct ncbigene:8664
EEF1G GeneProduct ncbigene:1937
EIF2S1 GeneProduct ncbigene:1965
EIF3S1 GeneProduct ncbigene:8669
EEF2K GeneProduct ncbigene:29904
EIF2B2 GeneProduct ncbigene:8892
EIF4A2 GeneProduct ncbigene:1974
EIF4E GeneProduct ncbigene:1977
EEF2 GeneProduct ncbigene:1938
EIF4EBP3 GeneProduct ncbigene:8637
EIF3S6 GeneProduct ncbigene:3646
EEF1D GeneProduct ncbigene:1936
EIF3S8 GeneProduct ncbigene:8663
EIF3S10 GeneProduct ncbigene:8661
EIF2B5 GeneProduct ncbigene:8893
EIF2AK3 GeneProduct ncbigene:9451
EIF5A GeneProduct ncbigene:1984
EIF3S5 GeneProduct ncbigene:8665
EIF1AX GeneProduct ncbigene:1964


  1. Gene-specific regulation by general translation factors. Dever TE. Cell. 2002 Feb 22;108(4):545–56. PubMed Europe PMC Scholia