Growth hormone (GH) signaling (WP2890)

Bos taurus

The growth Hormone/Insulin-Like Growth Factor axis is a complex system of ligands, binding protein and receptors which the cells use for communication of growth simulating signal. GH is released from the pituitary and by binding to the GH receptor it stimulates longitudinal growth and has anabolic effects on metabolism. Most of the growth-promoting effects of GH are mediated by IGF-1 which is produced mainly in the liver after GH stimulation. IGF-1 has crucial functions especially for embryonic growth and development. This pathway is primarily studied to understand factors that contribute to growth in bos taurus(Jiang et al.)


Zahra Roudbari , Martina Summer-Kutmon , and Eric Weitz


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Bos taurus



Pathway Ontology

growth factor signaling pathway


Label Type Compact URI Comment
GHR GeneProduct ncbigene:280805
IGFBP-3 GeneProduct ncbigene:282261
IGF-1 GeneProduct ncbigene:281239
STAT5b GeneProduct ncbigene:282376
GH1 GeneProduct ncbigene:280804
JAK2 GeneProduct ncbigene:525246
JAK2 GeneProduct ncbigene:525246
STAT5b GeneProduct ncbigene:282376
STAT5b GeneProduct ncbigene:282376
IGF-1 GeneProduct ncbigene:281239


  1. MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM--mechanism of growth hormone stimulation of skeletal muscle growth in cattle. Jiang H, Ge X. J Anim Sci. 2014 Jan;92(1):21–9. PubMed Europe PMC Scholia