Spinal cord injury (WP3186)

Bos taurus

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons. An example therapy is the administration of the immunosuppressant FK506, also used in transplantation to offer neuroprotection.

Authors

Martina Summer-Kutmon , Linda Rieswijk , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Disease Ontology

post-traumatic stress disorder spinal cord disease

Pathway Ontology

disease pathway

Cell Type Ontology

astrocyte of the spinal cord

Participants

Label Type Compact URI Comment
LTB4 Metabolite pubchem.compound:169
NO Metabolite pubchem.compound:145068
melittin Metabolite pubchem.compound:16133648
FK506 Metabolite cas:104987-11-3
FK506 Metabolite cas:104987-11-3
FK506 Metabolite cas:104987-11-3
FK506 Metabolite cas:104987-11-3
Arachidonic acid Metabolite hmdb:HMDB0001043
PGH2 Metabolite hmdb:HMDB0001381
Olomoucine Metabolite hmdb:HMDB0035233
2-Methoxyestradiol Metabolite pubchem.compound:66414
PD 168393 Metabolite pubchem.compound:4708
NGFR GeneProduct ensembl:ENSBTAG00000020979 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064300
APEX1 GeneProduct ensembl:ENSBTAG00000002745 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100823
MIF GeneProduct ensembl:ENSBTAG00000007375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000240972
OB GeneProduct ensembl:ENSBTAG00000014911 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174697
LGALS3 GeneProduct ensembl:ENSBTAG00000002326 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131981
TNFSF13 GeneProduct ensembl:ENSBTAG00000000130 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161955
LTB4R GeneProduct ensembl:ENSBTAG00000010238 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213903
AQP1 GeneProduct ensembl:ENSBTAG00000000745 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000240583
TNFSF13B GeneProduct ensembl:ENSBTAG00000045907 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102524
AIF1 GeneProduct ensembl:ENSBTAG00000020554 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:199
PTPRZ1 GeneProduct ensembl:ENSBTAG00000012119 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106278
PDYN GeneProduct ensembl:ENSBTAG00000045520 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101327
LTB GeneProduct ensembl:ENSBTAG00000020674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000227507
PLXNA2 GeneProduct ensembl:ENSBTAG00000001173 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000076356
CSPG4 GeneProduct ensembl:ENSBTAG00000012219 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173546
CD47 GeneProduct ensembl:ENSBTAG00000003585 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196776
C1QB GeneProduct ensembl:ENSBTAG00000011196 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173369
CDC42 GeneProduct ensembl:ENSBTAG00000001700 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831
ZFP36 GeneProduct ensembl:ENSBTAG00000008573 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128016
FCGR2C GeneProduct ensembl:ENSBTAG00000038124 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143226
PTPRA GeneProduct ensembl:ENSBTAG00000011425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132670
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538
ZFP36 GeneProduct ensembl:ENSBTAG00000008573 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128016
INOS GeneProduct ensembl:ENSBTAG00000006894 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000007171
TNF GeneProduct ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000232810
NR4A1 GeneProduct ensembl:ENSBTAG00000000507 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123358
IL4 GeneProduct ensembl:ENSBTAG00000015957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113520
BTG2 GeneProduct ensembl:ENSBTAG00000015711 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159388
BTG2 GeneProduct ensembl:ENSBTAG00000015711 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159388
CDK2 GeneProduct ensembl:ENSBTAG00000004021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123374
NOS1 GeneProduct ensembl:ENSBTAG00000002023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000089250
IL2 GeneProduct ensembl:ENSBTAG00000020883 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109471
TNF GeneProduct ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000232810
IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244
TLR4 GeneProduct ensembl:ENSBTAG00000006240 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136869
FOS GeneProduct ensembl:ENSBTAG00000004322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
TLR4 GeneProduct ensembl:ENSBTAG00000006240 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136869
TNF GeneProduct ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000232810
EGR1 GeneProduct ensembl:ENSBTAG00000010069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120738
FOS GeneProduct ensembl:ENSBTAG00000004322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111537
MBP GeneProduct ensembl:ENSBTAG00000022890 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197971
RTN4 GeneProduct ensembl:ENSBTAG00000011104 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115310
C5 GeneProduct ensembl:ENSBTAG00000012210 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106804
GRO1 GeneProduct ensembl:ENSBTAG00000037558 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163739
CXCL8 GeneProduct ensembl:ENSBTAG00000019716 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169429
AQP4 GeneProduct ensembl:ENSBTAG00000019037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171885
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538
INOS GeneProduct ensembl:ENSBTAG00000006894 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000007171
TNF GeneProduct ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000232810
ARG1 GeneProduct ensembl:ENSBTAG00000012403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118520
EPHA4 GeneProduct ensembl:ENSBTAG00000010030 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116106
EFNB2 GeneProduct ensembl:ENSBTAG00000016991 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125266
CXCL10 GeneProduct ensembl:ENSBTAG00000001725 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169245
CCNG1 GeneProduct ensembl:ENSBTAG00000006607 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113328
MMP9 GeneProduct ensembl:ENSBTAG00000020676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100985
NCAN GeneProduct ensembl:ENSBTAG00000001764 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130287
SLIT1 GeneProduct ensembl:ENSBTAG00000043991 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187122
SLIT2 GeneProduct ensembl:ENSBTAG00000005108 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145147
SLIT3 GeneProduct ensembl:ENSBTAG00000017746 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184347
NTN1 GeneProduct ensembl:ENSBTAG00000012137 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065320
RGMA GeneProduct ensembl:ENSBTAG00000018603 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182175
MMP9 GeneProduct ensembl:ENSBTAG00000020676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100985
MMP9 GeneProduct ensembl:ENSBTAG00000020676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100985
MMP9 GeneProduct ensembl:ENSBTAG00000020676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100985
CCR2 GeneProduct ensembl:ENSBTAG00000013586 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121807
IL1R1 GeneProduct ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115594
IL1A GeneProduct ensembl:ENSBTAG00000010349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552
GRO1 GeneProduct ensembl:ENSBTAG00000037558 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163739
GRO1 GeneProduct ensembl:ENSBTAG00000037558 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081041
CCL2 GeneProduct ensembl:ENSBTAG00000037811 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108691
PLA2G6 GeneProduct ensembl:ENSBTAG00000014015 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184381
PLA2G5 GeneProduct ensembl:ENSBTAG00000039122 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127472
PLA2G2A GeneProduct ensembl:ENSBTAG00000005759 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000188257
ANXA1 GeneProduct ensembl:ENSBTAG00000015978 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135046
ICAM1 GeneProduct ensembl:ENSBTAG00000010303 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090339
SELP GeneProduct ensembl:ENSBTAG00000020755 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174175
KLK8 GeneProduct ensembl:ENSBTAG00000015128 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129455
GFAP GeneProduct ensembl:ENSBTAG00000013534 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131095
CDK4 GeneProduct ensembl:ENSBTAG00000046091 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135446
NK1R GeneProduct ensembl:ENSBTAG00000015575 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115353
E2F5 GeneProduct ensembl:ENSBTAG00000009378 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133740
RB1 GeneProduct ensembl:ENSBTAG00000006640 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139687
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229
E2F1 GeneProduct ensembl:ENSBTAG00000003971 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101412
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
CCND1 GeneProduct ensembl:ENSBTAG00000017514 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110092
MYC GeneProduct ensembl:ENSBTAG00000008409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
GADD45A GeneProduct ensembl:ENSBTAG00000013860 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116717
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102882
TP53 GeneProduct ensembl:ENSBTAG00000001069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510
CHST11 GeneProduct ensembl:ENSBTAG00000010644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171310
VCAN GeneProduct ensembl:ENSBTAG00000014906 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000038427
COL4A1 GeneProduct ensembl:ENSBTAG00000012849 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187498
XYLT1 GeneProduct ensembl:ENSBTAG00000005523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103489
COL2A1 GeneProduct ensembl:ENSBTAG00000013155 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139219
ACAN GeneProduct ensembl:ENSBTAG00000016158 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157766
BCAN GeneProduct ensembl:ENSBTAG00000015789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132692
SOX9 GeneProduct ensembl:ENSBTAG00000045824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125398
TP53 GeneProduct ensembl:ENSBTAG00000001069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510
GRIN1 GeneProduct ensembl:ENSBTAG00000047202 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176884
VIM GeneProduct ensembl:ENSBTAG00000018463 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000026025
PPP3CA GeneProduct ensembl:ENSBTAG00000016005 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138814
GAP43 GeneProduct ensembl:ENSBTAG00000006451 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172020
FKBP1A GeneProduct ensembl:ENSBTAG00000032651 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000088832
IL2 GeneProduct ensembl:ENSBTAG00000020883 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109471
MAG GeneProduct ensembl:ENSBTAG00000017044 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105695
RTN4 GeneProduct ensembl:ENSBTAG00000011104 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115310
RHOA GeneProduct ensembl:ENSBTAG00000004279 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000067560
RHOC GeneProduct ensembl:ENSBTAG00000014299 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155366
RHOB GeneProduct ensembl:ENSBTAG00000046054 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143878
ROCK2 GeneProduct ensembl:ENSBTAG00000005847 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134318
OMG GeneProduct ensembl:ENSBTAG00000025213 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126861
RTN4R GeneProduct ensembl:ENSBTAG00000046677 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000040608
LILRB3 GeneProduct ensembl:ENSBTAG00000039932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204577
PGHS-2 GeneProduct ensembl:ENSBTAG00000014127 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
ROS1 GeneProduct ensembl:ENSBTAG00000047600 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6098
NOX4 GeneProduct ensembl:ENSBTAG00000018540 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000086991
CDK1 GeneProduct ensembl:ENSBTAG00000010109 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170312
GDNF GeneProduct ensembl:ENSBTAG00000005176 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168621
SEMA6A GeneProduct ensembl:ENSBTAG00000020489 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000092421
GJA1 GeneProduct ensembl:ENSBTAG00000001835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152661
BDNF GeneProduct ensembl:ENSBTAG00000008134 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176697
RAC1 GeneProduct ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136238
FOXO3 GeneProduct ensembl:ENSBTAG00000011234 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118689
CDKN1B GeneProduct ensembl:ENSBTAG00000018254 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111276
EGFR GeneProduct ensembl:ENSBTAG00000011628 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146648
CASP3 GeneProduct ensembl:ENSBTAG00000015874 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164305

References

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