Blood clotting cascade (WP1122)

Canis familiaris

Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Source: [[wikipedia:Coagulation|Wikipedia]]


Thomas Kelder , Christine Chichester , and Eric Weitz


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Canis familiaris



Pathway Ontology

coagulation cascade pathway


Label Type Compact URI Comment
F12 GeneProduct ncbigene:489090
F11 GeneProduct ncbigene:475623
F9 GeneProduct ncbigene:404015
F10 GeneProduct ncbigene:476993
F10 GeneProduct ncbigene:476993
VWF GeneProduct ncbigene:399544
F7 GeneProduct ncbigene:607661
F13B GeneProduct ncbigene:490261
SERPINF2 GeneProduct ncbigene:611266
PLAU GeneProduct ncbigene:403426
PLAT GeneProduct ncbigene:482840
SERPINB2 GeneProduct ncbigene:609604
SERPINE1 GeneProduct ncbigene:403476
PLG GeneProduct ncbigene:403602
FGB GeneProduct ncbigene:475472
FGA GeneProduct ncbigene:475473
FGG GeneProduct ncbigene:475474
F8 GeneProduct ncbigene:403875


  1. The current status of coagulation. Luchtman-Jones L, Broze GJ Jr. Ann Med. 1995 Feb;27(1):47–52. PubMed Europe PMC Scholia