Glycosphingolipid metabolism (WP5292)
Homo sapiens
Glycosphingolipid metabolism, based on sphingomap. Initial top level pathway
Authors
Conroy lipids and Egon WillighagenActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
sphingolipid biosynthetic pathway ganglioside metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| GlcCer | Metabolite | lipidmaps:LMSP0501AA00 | |
| GA2 | Metabolite | lipidmaps:LMSP0503AA00 | |
| nLc4Cer | Metabolite | lipidmaps:LMSP0505AA00 | |
| GM4 | Metabolite | lipidmaps:LMSP0601AA00 | |
| LacCer | Metabolite | lipidmaps:LMSP0501AB00 | |
| GalCer | Metabolite | lipidmaps:LMSP0501AC00 | |
| Gb3 | Metabolite | lipidmaps:LMSP0502AA00 | |
| Ceramide | Metabolite | lipidmaps:LMSP02010000 | |
| GM3 | Metabolite | lipidmaps:LMSP0601AJ00 | |
| CDG | Metabolite | lipidmaps:LMSP0509AA00 | |
| iGb3 | Metabolite | lipidmaps:LMSP0506AQ00 | |
| LM1 | Metabolite | lipidmaps:LMSP0504AB00 | |
| SM4 | Metabolite | lipidmaps:LMSP0602AN00 | |
| SM3 | Metabolite | lipidmaps:LMSP0602AA00 | |
| Lc3Cer | Metabolite | lipidmaps:LMSP0504AA00 | |
| GBA3 | GeneProduct | uniprot:Q9H227 | |
| A3GALT2 | GeneProduct | uniprot:U3KPV4 | |
| NEU4 | GeneProduct | uniprot:Q8WWR8 | |
| UGCG | GeneProduct | uniprot:Q16739 | |
| A4GALT | GeneProduct | uniprot:Q9NPC4 | |
| GBA1 | GeneProduct | uniprot:P04062 | |
| GLA | GeneProduct | uniprot:P06280 | |
| GALC | GeneProduct | uniprot:P54803 | |
| UGT8 | GeneProduct | uniprot:Q16880 | |
| B4GALT3 | GeneProduct | uniprot:O60512 | |
| B4GALT5 | GeneProduct | uniprot:O43286 | |
| B4GALT1 | GeneProduct | uniprot:O60513 | |
| B3GALT1 | GeneProduct | uniprot:Q9Y5Z6 | |
| GBA2 | GeneProduct | uniprot:Q9HCG7 | |
| NEU3 | GeneProduct | uniprot:Q9UQ49 | |
| B4GALNT1 | GeneProduct | uniprot:Q00973 | |
| ARSA | GeneProduct | uniprot:P15289 | |
| A4GALT | GeneProduct | uniprot:Q9NPC4 | |
| B3GNT5 | GeneProduct | uniprot:Q9BYG0 | |
| GAL3ST1 | GeneProduct | uniprot:Q99999 | |
| B3GALT2 | GeneProduct | uniprot:O43825 | |
| B4GALT6 | GeneProduct | uniprot:Q9UBX8 | |
| B4GALT4 | GeneProduct | uniprot:O60513 | |
| ST3GAL5 | GeneProduct | uniprot:Q9UNP4 | |
| GAL3ST1 | GeneProduct | uniprot:Q99999 | |
| ST3GAL5 | GeneProduct | uniprot:Q9UNP4 |
References
- Globoid cell leukodystrophy: deficiency of lactosyl ceramide beta-galactosidase. Wenger DA, Sattler M, Hiatt W. Proc Natl Acad Sci U S A. 1974 Mar;71(3):854–7. PubMed Europe PMC Scholia
- Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells. Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, et al. J Biol Chem. 1995 Mar 17;270(11):6149–55. PubMed Europe PMC Scholia
- Purification and characterization of 3’-phosphoadenosine-5’-phosphosulfate:GalCer sulfotransferase from human renal cancer cells. Honke K, Yamane M, Ishii A, Kobayashi T, Makita A. J Biochem. 1996 Mar;119(3):421–7. PubMed Europe PMC Scholia
- Characterization of two alpha-galactosidase mutants (Q279E and R301Q) found in an atypical variant of Fabry disease. Kase R, Bierfreund U, Klein A, Kolter T, Utsumi K, Itoha K, et al. Biochim Biophys Acta. 2000 Jun 15;1501(2–3):227–35. PubMed Europe PMC Scholia
- Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids. Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU. J Biol Chem. 2000 Aug 18;275(33):25308–14. PubMed Europe PMC Scholia
- Evidence for mitochondrial localization of a novel human sialidase (NEU4). Yamaguchi K, Hata K, Koseki K, Shiozaki K, Akita H, Wada T, et al. Biochem J. 2005 Aug 15;390(Pt 1):85–93. PubMed Europe PMC Scholia
- SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Merril AH Jr. Glycobiology. 2005 Jun;15(6):15G. PubMed Europe PMC Scholia