Serotonin receptor 4/6/7 and NR3C signaling (WP734)

Homo sapiens

This pathway depicts the downstream signaling of serotonin via receptors 4, 6, and 7, resulting in the activation of EGR1 and NR3C1. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP734 CPTAC Assay Portal]

Authors

Ruke Achoja , Kristina Hanspers , Alex Pico , Thomas Kelder , Allan Kuchinsky , Andra Waagmeester , Egon Willighagen , Eric Weitz , and Denise Slenter

Activity

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

neuron

Pathway Ontology

serotonin signaling pathway

Participants

Label Type Compact URI Comment
Cyclic AMP Metabolite cas:60-92-4
serotonin Metabolite cas:50-67-9
BRAF GeneProduct ncbigene:673 v-raf murine sarcoma viral oncogene homolog B1
HTR7 GeneProduct ncbigene:3363 5-hydroxytryptamine (serotonin) receptor 7
SRF GeneProduct ncbigene:6722 serum response factor
ELK4 GeneProduct ncbigene:2005 ETS domain-containing protein Elk-4 (SRF accessory protein 1)
EGR1 GeneProduct ncbigene:1958 early growth response protein
HTR6 GeneProduct ncbigene:3362 5-hydroxytryptamine (serotonin) receptor 6
GNAS GeneProduct ncbigene:2778 GNAS (guanine nucleotide binding protein, alpha stimulating)
ATF1 GeneProduct ncbigene:466 activating transcription factor 1
MAP2K2 GeneProduct ncbigene:5605 mitogen activated protein kinase kinase 2
MAPK3 GeneProduct ncbigene:5595 mitogen activated protein kinase 3
CREB1 GeneProduct ncbigene:1385 cAMP response element-binding protein 1
MAPK1 GeneProduct hgnc.symbol:MAPK1 mitogen activated protein kinase 1
MAP2K1 GeneProduct ncbigene:5604 mitogen activated protein kinase kinase 1
RPS6KA5 GeneProduct ncbigene:9252 ribosomal protein S6 kinase, polypeptide 5
NR3C1 GeneProduct ncbigene:2908 nuclear receptor, subfamily 3, group C, member 1
RAP1A GeneProduct ncbigene:5906 RAS-related protein-1a
MAPKAPK2 GeneProduct ncbigene:9261 MAP kinase-activated protein kinase 2
ELK1 GeneProduct ncbigene:2002 ELK1, member of ETS oncogene family
HTR4 GeneProduct ncbigene:3360 5 hydroxytryptamine (serotonin) receptor 4

References

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  81. Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1. Sananbenesi F, Fischer A, Schrick C, Spiess J, Radulovic J. Mol Cell Neurosci. 2002 Nov;21(3):463–76. PubMed Europe PMC Scholia
  82. Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3’,5’-monophosphate regulatory element binding protein, serum response factor, sp1, and early growth response factor-1. Russell DL, Doyle KMH, Gonzales-Robayna I, Pipaon C, Richards JS. Mol Endocrinol. 2003 Apr;17(4):520–33. PubMed Europe PMC Scholia
  83. pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK-induced LDL receptor transcription in HepG2 cells. Kapoor GS, Golden C, Atkins B, Mehta KD. J Lipid Res. 2003 Mar;44(3):584–93. PubMed Europe PMC Scholia
  84. Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3. Bakovic M, Waite K, Vance DE. J Biol Chem. 2003 Apr 25;278(17):14753–61. PubMed Europe PMC Scholia
  85. Independent and cooperative activation of chromosomal c-fos promoter by STAT3. Yang E, Lerner L, Besser D, Darnell JE Jr. J Biol Chem. 2003 May 2;278(18):15794–9. PubMed Europe PMC Scholia
  86. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G. EMBO J. 2003 Mar 17;22(6):1313–24. PubMed Europe PMC Scholia
  87. Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway? Budnik LT, Brunswig-Spickenheier B, Mukhopadhyay AK. Mol Endocrinol. 2003 Aug;17(8):1593–606. PubMed Europe PMC Scholia
  88. Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. Ahmed I, Gesty-Palmer D, Drezner MK, Luttrell LM. Mol Endocrinol. 2003 Aug;17(8):1607–21. PubMed Europe PMC Scholia
  89. Regulation of PRAK subcellular location by p38 MAP kinases. New L, Jiang Y, Han J. Mol Biol Cell. 2003 Jun;14(6):2603–16. PubMed Europe PMC Scholia
  90. Mek2 is dispensable for mouse growth and development. Bélanger LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, et al. Mol Cell Biol. 2003 Jul;23(14):4778–87. PubMed Europe PMC Scholia
  91. Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy. Dillon TJ, Karpitski V, Wetzel SA, Parker DC, Shaw AS, Stork PJS. J Biol Chem. 2003 Sep 19;278(38):35940–9. PubMed Europe PMC Scholia
  92. MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils. Coxon PY, Rane MJ, Uriarte S, Powell DW, Singh S, Butt W, et al. Cell Signal. 2003 Nov;15(11):993–1001. PubMed Europe PMC Scholia
  93. MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. Chrestensen CA, Schroeder MJ, Shabanowitz J, Hunt DF, Pelo JW, Worthington MT, et al. J Biol Chem. 2004 Mar 12;279(11):10176–84. PubMed Europe PMC Scholia
  94. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Bai X chun, Lu D, Bai J, Zheng H, Ke Z yong, Li X ming, et al. Biochem Biophys Res Commun. 2004 Jan 30;314(1):197–207. PubMed Europe PMC Scholia
  95. Developmental regulation of the 5-HT7 serotonin receptor and transcription factor NGFI-A in the fetal guinea-pig limbic system: influence of GCs. Andrews MH, Kostaki A, Setiawan E, McCabe L, Owen D, Banjanin S, et al. J Physiol. 2004 Mar 16;555(Pt 3):659–70. PubMed Europe PMC Scholia
  96. Transformation potency of ErbB heterodimer signaling is determined by B-Raf kinase. Hatakeyama M, Yumoto N, Yu X, Shirouzu M, Yokoyama S, Konagaya A. Oncogene. 2004 Jun 24;23(29):5023–31. PubMed Europe PMC Scholia
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