Interleukin-1 induced activation of NF-kB (WP3656)
Interleukin-1 Induced activation of NF-kB through the phosphorylated TRAF6/Ajuba/PKCz/SQST1 complex. The pathway is defined by multiple binding steps to the TRAF6/Ajuba/PKCz/SQST1 complex. The small arrows constitute a earlier binding. After binding occurs the complex is phosphorylated and activates NF-kB. This pathway is based on figure 6 from Li et al.
AuthorsAAR&Co , Jonathan Mélius , Kristina Hanspers , Egon Willighagen , and Eric Weitz
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Pathway Ontologysignaling pathway
- Identification of potential pathway mediation targets in Toll-like receptor signaling. Li F, Thiele I, Jamshidi N, Palsson BØ. PLoS Comput Biol. 2009 Feb;5(2):e1000292. PubMed Europe PMC Scholia