Major receptors targeted by epinephrine and norepinephrine (WP4589)

Homo sapiens

The physiologic "fear" response is associated with the signaling activity of adrenergic receptors stimulated by epinephrine/norepinephrine.


Chris Gillissen , Egon Willighagen , Friederike Ehrhart , Denise Slenter , Alex Pico , Kristina Hanspers , and Finterly Hu


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Homo sapiens



Pathway Ontology

norepinephrine signaling pathway epinephrine signaling pathway classic metabolic pathway


Label Type Compact URI Comment
calcium Metabolite chebi:29108
ATP Metabolite chebi:30616
Epinephrine Metabolite wikidata:Q132621 AKA adrenaline
Serine Metabolite chebi:17115
DAG Metabolite wikidata:Q161466 diacylglycerol
pyro-phosphate Metabolite chebi:33019
cAMP Metabolite chebi:58165
Threonine Metabolite chebi:57926
Serine Metabolite chebi:17115
Threonine Metabolite chebi:57926
β2 receptor Protein uniprot:P07550 G protein–coupled receptor (GPCR)
β1 receptor Protein uniprot:P08588 G protein–coupled receptor (GPCR)
PKC Protein eccode: Protein Kinase C
α1A receptor Protein uniprot:P3548
α2A receptor Protein uniprot:P08913
PKA Protein eccode: Protein Kinase A
ADCY1 Protein uniprot:Q08828
AC Protein eccode:
α1B receptor Protein uniprot:P3568
α1D receptor Protein uniprot:P25100
α2B receptor Protein uniprot:P18089
α2C receptor Protein uniprot:P18825
AC Protein eccode:
AC Protein eccode: 'There are ten known isoforms of adenylyl cyclases in mammals' []
ADCY2 Protein uniprot:Q08462
ADCY3 Protein uniprot:O60266
ADCY4 Protein uniprot:Q8NFM4
ADCY5 Protein uniprot:O95622
ADCY6 Protein uniprot:O43306
ADCY7 Protein uniprot:P51828
ADCY8 Protein uniprot:P40145
ADCY9 Protein uniprot:O60503
ADCY10 Protein uniprot:Q96PN6


  1. The Fats of Life [Internet]. Lawrence GD. 2010. 277 p. Available from: OpenLibrary Worldcat