Major receptors targeted by epinephrine and norepinephrine (WP4589)

Homo sapiens

The physiologic "fear" response is associated with the signaling activity of adrenergic receptors stimulated by epinephrine and norepinephrine.

Authors

Chris Gillissen , Egon Willighagen , Friederike Ehrhart , Denise Slenter , Alex Pico , Kristina Hanspers , Finterly Hu , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

hepatocyte cell of skeletal muscle cardiac muscle cell

Pathway Ontology

norepinephrine signaling pathway epinephrine signaling pathway classic metabolic pathway

Participants

Label Type Compact URI Comment
Ca2+ Metabolite chebi:29108
ATP Metabolite chebi:30616
Epinephrine Metabolite wikidata:Q132621 AKA adrenaline
Serine Metabolite chebi:17115
DAG Metabolite wikidata:Q161466 diacylglycerol
Pyro-phosphate Metabolite chebi:33019
cAMP Metabolite chebi:58165
Threonine Metabolite chebi:57926
β2 receptor Protein uniprot:P07550 G protein–coupled receptor (GPCR)
β1 receptor Protein uniprot:P08588 G protein–coupled receptor (GPCR)
PKC Protein eccode:2.7.11.13 Protein Kinase C
α1A receptor Protein uniprot:P3548
α2A receptor Protein uniprot:P08913
PKA Protein eccode:2.7.11.11 Protein Kinase A
ADCY1 Protein uniprot:Q08828
α1B receptor Protein uniprot:P3568
α1D receptor Protein uniprot:P25100
α2B receptor Protein uniprot:P18089
α2C receptor Protein uniprot:P18825
AC Protein eccode:4.6.1.1
AC Protein eccode:4.6.1.1 'There are ten known isoforms of adenylyl cyclases in mammals' [https://en.wikipedia.org/wiki/Adenylyl_cyclase]
ADCY2 Protein uniprot:Q08462
ADCY3 Protein uniprot:O60266
ADCY4 Protein uniprot:Q8NFM4
ADCY5 Protein uniprot:O95622
ADCY6 Protein uniprot:O43306
ADCY7 Protein uniprot:P51828
ADCY8 Protein uniprot:P40145
ADCY9 Protein uniprot:O60503
ADCY10 Protein uniprot:Q96PN6

References

  1. The Fats of Life [Internet]. Lawrence GD. 2010. 277 p. Available from: https://books.google.com/books/about/The_Fats_of_Life.html?hl=&id=_67cmAEACAAJ OpenLibrary Worldcat