Major receptors targeted by epinephrine and norepinephrine (WP4589)
Homo sapiens
The physiologic "fear" response is associated with the signaling activity of adrenergic receptors stimulated by epinephrine/norepinephrine.
Authors
Chris Gillissen , Egon Willighagen , Friederike Ehrhart , Denise Slenter , Alex Pico , Kristina Hanspers , and Finterly HuActivity
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Cited By
- Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients (2022).
- Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract (2021).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
epinephrine signaling pathway classic metabolic pathway norepinephrine signaling pathway| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| calcium | Metabolite | chebi:22984 | |
| ATP | Metabolite | chebi:30616 | |
| Epinephrine | Metabolite | wikidata:Q132621 | AKA adrenaline |
| Serine | Metabolite | chebi:17115 | |
| DAG | Metabolite | wikidata:Q161466 | diacylglycerol |
| pyro-phosphate | Metabolite | chebi:33019 | |
| cAMP | Metabolite | chebi:58165 | |
| Threonine | Metabolite | chebi:57926 | |
| Serine | Metabolite | chebi:17115 | |
| Threonine | Metabolite | chebi:57926 | |
| β2 receptor | Protein | uniprot:P07550 | G protein–coupled receptor (GPCR) |
| β1 receptor | Protein | uniprot:P08588 | G protein–coupled receptor (GPCR) |
| PKC | Protein | eccode:2.7.11.13 | Protein Kinase C |
| α1A receptor | Protein | uniprot:P3548 | |
| α2A receptor | Protein | uniprot:P08913 | |
| PKA | Protein | eccode:2.7.11.11 | Protein Kinase A |
| ADCY1 | Protein | uniprot:Q08828 | |
| AC | Protein | eccode:4.6.1.1 | |
| α1B receptor | Protein | uniprot:P3568 | |
| α1D receptor | Protein | uniprot:P25100 | |
| α2B receptor | Protein | uniprot:P18089 | |
| α2C receptor | Protein | uniprot:P18825 | |
| AC | Protein | eccode:4.6.1.1 | |
| AC | Protein | eccode:4.6.1.1 | 'There are ten known isoforms of adenylyl cyclases in mammals' [https://en.wikipedia.org/wiki/Adenylyl_cyclase] |
| ADCY2 | Protein | uniprot:Q08462 | |
| ADCY3 | Protein | uniprot:O60266 | |
| ADCY4 | Protein | uniprot:Q8NFM4 | |
| ADCY5 | Protein | uniprot:O95622 | |
| ADCY6 | Protein | uniprot:O43306 | |
| ADCY7 | Protein | uniprot:P51828 | |
| ADCY8 | Protein | uniprot:P40145 | |
| ADCY9 | Protein | uniprot:O60503 | |
| ADCY10 | Protein | uniprot:Q96PN6 |
References
- Lawrence GD. The Fats of Life [Internet]. 2010. 277 p. Available from: https://books.google.com/books/about/The_Fats_of_Life.html?hl=&id=_67cmAEACAAJ OpenLibrary Worldcat