Hepatocyte growth factor receptor signaling (WP313)

Homo sapiens

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP313 CPTAC Assay Portal].


Martijn Van Iersel , Kristina Hanspers , Martina Summer-Kutmon , Zahra Roudbari , Roelod , Eric Weitz , and Denise Slenter


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Homo sapiens




Pathway Ontology

Rho/Rac/Cdc42 mediated signaling pathway scatter factor/hepatocyte growth factor signaling pathway

Cell Type Ontology



Label Type Compact URI Comment
FOS GeneProduct ncbigene:2353
PTPN11 GeneProduct ncbigene:5781
ELK1 GeneProduct ncbigene:2002
MAP4K1 GeneProduct ncbigene:11184
PXN GeneProduct ncbigene:5829
MAPK1 GeneProduct ncbigene:5594
PIK3CA GeneProduct ncbigene:5290
PAK1 GeneProduct ncbigene:5058
GRB2 GeneProduct ncbigene:2885
PXN GeneProduct ncbigene:5829
MAPK8 GeneProduct ncbigene:5599
Met GeneProduct ncbigene:4233
PTK2B GeneProduct ncbigene:2185
JUN GeneProduct ncbigene:3725
SRC GeneProduct ncbigene:6714
RAP1B GeneProduct ncbigene:5908
CRKL GeneProduct ncbigene:1399
GAB1 GeneProduct ncbigene:2549
SRC GeneProduct ncbigene:6714
HRAS GeneProduct ncbigene:3265
STAT3 GeneProduct ncbigene:6774
CRK GeneProduct ncbigene:1398
PTEN GeneProduct ncbigene:5728
MAP2K2 GeneProduct ncbigene:5605
RAF1 GeneProduct ncbigene:5894
PTK2 GeneProduct ncbigene:5747
RAPGEF1 GeneProduct ncbigene:2889
RASA1 GeneProduct ncbigene:5921
MAPK3 GeneProduct ncbigene:5595
RAP1A GeneProduct ncbigene:5906
MAP2K1 GeneProduct ncbigene:5604
ITGB1 GeneProduct ncbigene:3688
PTK2 GeneProduct ncbigene:5747
DOCK1 GeneProduct ncbigene:1793 Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
HGF GeneProduct ncbigene:3082
PTK2B GeneProduct ncbigene:2185
ITGA1 GeneProduct ncbigene:3672
SOS1 GeneProduct ncbigene:6654 Son of sevenless homolog 1 (Drosophila) (predicted)


  1. An overview of the c-MET signaling pathway. Organ SL, Tsao MS. Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S7–19. PubMed Europe PMC Scholia