Axon guidance (WP5289)
Homo sapiens
Axon guidance forms neuronal networks. Axons are guided by factors including netrins, ephrins, Slits, and semaphorins. These guidance cues interact with growth cone receptors, and downstream signal transduction pathways converge onto Rho GTPases which change in cytoskeletal organization. Those cytoskeletal changes determine which way the growth cone will turn. This pathway is derived from KEGG.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Luiz C. M. Ladeira , Kristina Hanspers , Eric Weitz , and Egon WillighagenActivity
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Cited In
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Organisms
Homo sapiensCommunities
ONTOXAnnotations
Cell Type Ontology
neuronPathway Ontology
signaling pathway pertinent to the brain and nervous system| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ca²⁺ | Metabolite | chebi:29108 | |
| DCC | Protein | refseq:NM_005215 | |
| LRRC4C | Protein | ensembl:ENSG00000148948 | |
| CFL1 | Protein | ensembl:ENSG00000172757 | |
| RHOA | Protein | hgnc:667 | |
| PLXNA1 | Protein | ensembl:ENSG00000114554 | |
| NRP1 | Protein | ncbigene:8829 | |
| L1CAM | Protein | uniprot:P32004 | |
| SEMA3A | Protein | refseq:NM_006080 | |
| FES | Protein | refseq:NM_002005 | |
| FYN | Protein | hgnc.symbol:FYN | |
| CDK5 | Protein | hgnc.symbol:CDK5 | |
| PLCG1 | Protein | hgnc:9065 | |
| DPYSL5 | Protein | uniprot:Q9BPU6 | |
| DPYSL2 | Protein | refseq:NM_001386 | |
| PLXNB2 | Protein | hgnc:9104 | |
| SEMA4F | Protein | hgnc:10734 | |
| SEMA5B | Protein | ncbigene:54437 | |
| SEMA6C | Protein | ensembl:ENSG00000143434 | |
| SEMA7A | Protein | ncbigene:8482 | |
| MET | Protein | hgnc.symbol:MET | |
| PLXNC1 | Protein | hgnc:9106 | |
| PTK2 | Protein | hgnc:9611 | |
| ITGB1 | Protein | refseq:NM_002211 | |
| RAC1 | Protein | ncbigene:5879 | |
| PAK4 | Protein | hgnc:16059 | |
| RRAS | Protein | hgnc.symbol:RRAS | |
| RND1 | Protein | hgnc:18314 | |
| ARHGEF12 | Protein | refseq:NM_015313 | |
| SRC | Protein | uniprot:P12931 | |
| RAF1 | Protein | ensembl:ENSG00000132155 | |
| MAPK1 | Protein | ensembl:ENSG00000100030 | |
| SHH | Protein | uniprot:Q15465 | |
| PTCH1 | Protein | refseq:NM_000264 | |
| SMO | Protein | hgnc:11119 | |
| BOC | Protein | ncbigene:91653 | |
| PRKCA | Protein | hgnc.symbol:PRKCA | |
| ILK | Protein | ensembl:ENSG00000166333 | |
| WNT5A | Protein | hgnc.symbol:WNT5A | |
| FZD3 | Protein | hgnc.symbol:FZD3 | |
| RYK | Protein | ensembl:ENSG00000163785 | |
| TRPC1 | Protein | hgnc.symbol:TRPC1 | |
| CAMK2A | Protein | hgnc:1460 | |
| WNT4 | Protein | ensembl:ENSG00000162552 | |
| UNC5D | Protein | uniprot:Q6UXZ4 | |
| PIK3CA | Protein | hgnc:8975 | |
| PDPK1 | Protein | ensembl:ENSG00000140992 | |
| PRKCZ | Protein | ncbigene:5590 | |
| PARD3 | Protein | hgnc.symbol:PARD3 | |
| PARD6A | Protein | ensembl:ENSG00000102981 | |
| PPP3CA | Protein | hgnc:9314 | |
| NTN1 | Protein | hgnc:8029 | |
| BMPR2 | Protein | ncbigene:659 | |
| BMPR1B | Protein | ncbigene:658 | |
| BMP7 | Protein | hgnc:1074 | |
| GDF7 | Protein | hgnc.symbol:GDF7 | |
| LIMK1 | Protein | hgnc:6613 | |
| NTN3 | Protein | ncbigene:4917 | |
| CDC42 | Protein | ncbigene:998 | |
| NCK2 | Protein | hgnc:7665 | |
| GSK3B | Protein | hgnc.symbol:GSK3B | |
| NTN4 | Protein | ncbigene:59277 | |
| LRRC4 | Protein | hgnc:15586 | |
| NCK1 | Protein | ensembl:ENSG00000158092 | |
| PTPN11 | Protein | hgnc:9644 | |
| NFATC2 | Protein | hgnc:7776 | |
| ROCK1 | Protein | ncbigene:6093 | |
| ABLIM3 | Protein | uniprot:O94929 | |
| NEO1 | Protein | hgnc:7754 | |
| LRIG2 | Protein | ncbigene:9860 | |
| NTNG1 | Protein | hgnc:23319 | |
| RGMA | Protein | ncbigene:56963 | |
| MYL12B | Protein | ncbigene:103910 | |
| EPHA2 | Protein | hgnc.symbol:EPHA2 | |
| EPHB1 | Protein | hgnc.symbol:EPHB1 | |
| ABL1 | Protein | ensembl:ENSG00000097007 | |
| NTNG2 | Protein | refseq:NM_032536 | |
| RASA1 | Protein | refseq:NM_002890 | |
| NGEF | Protein | uniprot:Q8N5V2 | |
| ENAH | Protein | refseq:NM_018212 | |
| HRAS | Protein | ensembl:ENSG00000174775 | |
| EFNA1 | Protein | ncbigene:1942 | |
| EFNB1 | Protein | uniprot:P98172 | |
| CXCR4 | Protein | refseq:NM_001008540 | |
| CXCL12 | Protein | uniprot:P48061 | |
| RGS3 | Protein | hgnc:9999 | |
| GNAI1 | Protein | refseq:NM_002069 | |
| ROBO2 | Protein | refseq:NM_001128929 | |
| ROBO1 | Protein | uniprot:Q9Y6N7 | |
| SLIT1 | Protein | hgnc.symbol:SLIT1 | |
| SLIT2 | Protein | ncbigene:9353 | |
| SLIT3 | Protein | hgnc.symbol:SLIT3 | |
| ROBO3 | Protein | refseq:NM_022370 | |
| SRGAP2 | Protein | refseq:NM_015326 | |
| RHOD | Protein | uniprot:O00212 |
References
- Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres. Goto-Silva L, Martins M, Murillo JR, Souza LRQ, Vitória G, Oliveira JT, et al. Biochim Biophys Acta Proteins Proteom. 2021 Aug;1869(8):140656. PubMed Europe PMC Scholia
- URL: https://www.kegg.jp/entry/map04360