Farnesoid X receptor pathway (WP2879)

Homo sapiens

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The farnesoid X receptor (FXR, a.k.a. NR1H4) is a nuclear receptor that responds to levels of bile acids present in the body and regulates many processes related to bile acids synthesis and transport. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2879 CPTAC Assay Portal]

Authors

Rianne Fijten , Kristina Hanspers , Egon Willighagen , Friederike Ehrhart , Susan Coort , Alex Pico , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

bile acid signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
FXR ligand Metabolite chebi:48705 T3
Ligand Metabolite chebi:48705
Ligand Metabolite chebi:48705
Ligand Metabolite chebi:48705
NR1H4 GeneProduct ncbigene:9971 nuclear receptor subfamily 1, group H, member 4
NR1H4 GeneProduct ncbigene:9971 nuclear receptor subfamily 1, group H, member 4
RXRA GeneProduct ncbigene:6256 retinoid X receptor, alpha
NR1H4 GeneProduct ncbigene:9971 nuclear receptor subfamily 1, group H, member 4
RXRA GeneProduct ncbigene:6256 retinoid X receptor, alpha
NR1H4 GeneProduct ncbigene:9971 nuclear receptor subfamily 1, group H, member 4
RXRA GeneProduct ncbigene:6256 retinoid X receptor, alpha
UGT2B4 GeneProduct ncbigene:7363 UDP glucuronosyltransferase 2 family, polypeptide B4
SULT2A1 GeneProduct ncbigene:6822 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SLC27A5 GeneProduct ncbigene:10998 solute carrier family 27 (fatty acid transporter), member 5
SLC10A1 GeneProduct ncbigene:6554 solute carrier family 10 (sodium/bile acid cotransporter), member 1
CYP7A1 GeneProduct ncbigene:1581 cytochrome P450, family 7, subfamily A, polypeptide 1
NR0B2 GeneProduct ncbigene:8431 nuclear receptor subfamily 0, group B, member 2
FGF19 GeneProduct ncbigene:9965 fibroblast growth factor 19
IRS2 GeneProduct ncbigene:8660 insulin receptor substrate 2
ABCB11 GeneProduct ncbigene:8647 ATP-binding cassette, sub-family B (MDR/TAP), member 11
BAAT GeneProduct ncbigene:570 bile acid CoA:amino acid N-acyltransferase
CYP3A4 GeneProduct ncbigene:1576 cytochrome P450, family 3, subfamily A, polypeptide 4
FKBP5 GeneProduct ncbigene:2289 FK506 binding protein 5
IP6K3 GeneProduct ncbigene:117283 inositol hexakisphosphate kinase 3
ABCB4 GeneProduct ncbigene:5244 ATP-binding cassette, sub-family B (MDR/TAP), member 4
NR0B2 GeneProduct ncbigene:8431 nuclear receptor subfamily 0, group B, member 2
PPARGC1A GeneProduct ncbigene:10891 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
SLCO2B1 GeneProduct ncbigene:11309 solute carrier organic anion transporter family, member 2B1
CYP8B1 GeneProduct ncbigene:1582 cytochrome P450, family 8, subfamily B, polypeptide 1

References

  1. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Handschin C, Meyer UA. Arch Biochem Biophys. 2005 Jan 15;433(2):387–96. PubMed Europe PMC Scholia
  2. Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. Gadaleta RM, van Mil SWC, Oldenburg B, Siersema PD, Klomp LWJ, van Erpecum KJ. Biochim Biophys Acta. 2010 Jul;1801(7):683–92. PubMed Europe PMC Scholia
  3. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia