Hypothetical network for drug addiction

Hypothetical network for drug addiction (WP1281)

Adapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].

Christine Chichester , Egon Willighagen , and Eric Weitz

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Rattus norvegicus

substance dependence pathway

Label	Type	Compact URI
Cyclic AMP	Metabolite	chebi:17489
Ca++	Metabolite	chebi:29108
D-Glutamate	Metabolite	chebi:15966
Camk4	GeneProduct	ncbigene:25050
Ppa1	GeneProduct	ncbigene:294504
Grin2c	GeneProduct	ncbigene:24411
Adcy1	GeneProduct	ncbigene:305509
Zhx2	GeneProduct	ncbigene:314988
Drd4	GeneProduct	ncbigene:25432
GRIA1	GeneProduct	ncbigene:50592
Terf2ip	GeneProduct	ncbigene:307861
Krit1	GeneProduct	ncbigene:362317
Grin2d	GeneProduct	ncbigene:24412
Adcy8	GeneProduct	ncbigene:29241
Prkce	GeneProduct	ncbigene:29340
Grm5	GeneProduct	ncbigene:24418
Grm1	GeneProduct	ncbigene:24414
Acta1	GeneProduct	ncbigene:29437
Gria4	GeneProduct	ncbigene:29629
Mapk3	GeneProduct	ncbigene:50689
Mapk1	GeneProduct	ncbigene:116590
Map2k2	GeneProduct	ncbigene:58960
Gria3	GeneProduct	ncbigene:29628
Adcy1	GeneProduct	ncbigene:305509
Nisch	GeneProduct	ncbigene:306255
Grin2b	GeneProduct	ncbigene:24410
Drd2	GeneProduct	ncbigene:24318
Drd1a	GeneProduct	ncbigene:24316
Gria2	GeneProduct	ncbigene:29627
Map2k1	GeneProduct	ncbigene:170851
Grin2a	GeneProduct	ncbigene:24409
Creb1	GeneProduct	ncbigene:81646
Camk2b	GeneProduct	ncbigene:24245
Grin1	GeneProduct	ncbigene:24408
Prkaca	GeneProduct	ncbigene:25636
Prkaca	GeneProduct	ncbigene:25636

Genes and (common) pathways underlying drug addiction. Li CY, Mao X, Wei L. PLoS Comput Biol. 2008 Jan;4(1):e2. PubMed Europe PMC Scholia