Hypothetical network for drug addiction (WP1281)

Rattus norvegicus

Adapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].


Christine Chichester , Egon Willighagen , and Eric Weitz


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Rattus norvegicus



Pathway Ontology

substance dependence pathway


Label Type Compact URI Comment
Cyclic AMP Metabolite chebi:17489
Ca++ Metabolite chebi:29108
D-Glutamate Metabolite chebi:15966
Camk4 GeneProduct ncbigene:25050
Ppa1 GeneProduct ncbigene:294504
Grin2c GeneProduct ncbigene:24411
Adcy1 GeneProduct ncbigene:305509
Zhx2 GeneProduct ncbigene:314988
Drd4 GeneProduct ncbigene:25432
GRIA1 GeneProduct ncbigene:50592
Terf2ip GeneProduct ncbigene:307861
Krit1 GeneProduct ncbigene:362317
Grin2d GeneProduct ncbigene:24412
Adcy8 GeneProduct ncbigene:29241
Prkce GeneProduct ncbigene:29340
Grm5 GeneProduct ncbigene:24418
Grm1 GeneProduct ncbigene:24414
Acta1 GeneProduct ncbigene:29437
Gria4 GeneProduct ncbigene:29629
Mapk3 GeneProduct ncbigene:50689
Mapk1 GeneProduct ncbigene:116590
Map2k2 GeneProduct ncbigene:58960
Gria3 GeneProduct ncbigene:29628
Adcy1 GeneProduct ncbigene:305509
Nisch GeneProduct ncbigene:306255
Grin2b GeneProduct ncbigene:24410
Drd2 GeneProduct ncbigene:24318
Drd1a GeneProduct ncbigene:24316
Gria2 GeneProduct ncbigene:29627
Map2k1 GeneProduct ncbigene:170851
Grin2a GeneProduct ncbigene:24409
Creb1 GeneProduct ncbigene:81646
Camk2b GeneProduct ncbigene:24245
Grin1 GeneProduct ncbigene:24408
Prkaca GeneProduct ncbigene:25636
Prkaca GeneProduct ncbigene:25636


  1. Genes and (common) pathways underlying drug addiction. Li CY, Mao X, Wei L. PLoS Comput Biol. 2008 Jan;4(1):e2. PubMed Europe PMC Scholia