GPCRs, class C metabotropic glutamate, pheromone (WP501)

Homo sapiens

This pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.


Nathan Salomonis , Alex Pico , Bruce Conklin , Kristina Hanspers , Egon Willighagen , and Eric Weitz


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Homo sapiens



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
GRM1 GeneProduct ncbigene:2911
GRM5 GeneProduct ncbigene:2915
GRM2 GeneProduct ncbigene:2912
GRM3 GeneProduct ncbigene:2913
GRM8 GeneProduct ncbigene:2918
GRM4 GeneProduct ncbigene:2914
GRM7 GeneProduct ncbigene:2917
GRM6 GeneProduct ncbigene:2916
CASR GeneProduct ncbigene:846
GABBR1 GeneProduct ncbigene:2550
GPR51 GeneProduct ncbigene:9568
GPRC5D GeneProduct ncbigene:55507
GPRC5C GeneProduct ncbigene:55890
GPRC5B GeneProduct ncbigene:51704
GPRC5A GeneProduct ncbigene:9052


  1. GPCRDB: an information system for G protein-coupled receptors. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Classifying G-protein coupled receptors with support vector machines. Karchin R, Karplus K, Haussler D. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia