Ascaroside biosynthesis (WP2224)

Caenorhabditis elegans

A proposed role of peroxisomal beta-oxidation enzymes in ascaroside biosynthesis in C. elegans. Ascarosides are small-molecule pheromones that play a role in dauer formation, mating attraction, and social feeding behaviors.


Karen Yook , Christine Chichester , Martina Summer-Kutmon , Alex Pico , and Eric Weitz


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Caenorhabditis elegans



Pathway Ontology

ascaroside biosynthetic pathway lipid metabolic pathway


Label Type Compact URI Comment
acox-1 GeneProduct ensembl:WBGene00008564
MAOC-1 GeneProduct wormbase:E04F6.3
DHS-28 GeneProduct wormbase:M03A8.1
DAF-22 GeneProduct wormbase:Y57A10C.6


  1. Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans. von Reuss SH, Bose N, Srinivasan J, Yim JJ, Judkins JC, Sternberg PW, et al. J Am Chem Soc. 2012 Jan 25;134(3):1817–24. PubMed Europe PMC Scholia