Fas ligand pathway and stress induction of heat shock proteins (WP314)

Homo sapiens

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This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP314 CPTAC Assay Portal]

Authors

Kristina Hanspers , Thomas Kelder , JT. Saito , Jildau Bouwman , Alex Pico , Christine Chichester , Zahra Roudbari , Marianthi Kalafati , Lauren J. Dupuis , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

stress response pathway FasL mediated signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
Glutathione Metabolite hmdb:HMDB0000125
Phosphate Metabolite hmdb:HMDB0001429
Phosphate Metabolite hmdb:HMDB0001429
Phosphate Metabolite hmdb:HMDB0001429
Phosphate Metabolite hmdb:HMDB0001429
Phosphate Metabolite hmdb:HMDB0001429
Phosphate Metabolite hmdb:HMDB0001429
Phosphate Metabolite hmdb:HMDB0001429
Ceramide Metabolite cas:104404-17-3
SPTAN1 GeneProduct ncbigene:6709 Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
IL1A GeneProduct ncbigene:3552
FAF1 GeneProduct ncbigene:11124
CASP7 GeneProduct ncbigene:840
HSPB1 GeneProduct ncbigene:3315
RIPK2 GeneProduct ncbigene:8767 receptor (TNFRSF)-interacting serine-threonine kinase 2
DFFB GeneProduct ncbigene:1677
PAK1 GeneProduct ncbigene:5058
APAF1 GeneProduct ncbigene:317
DAXX GeneProduct ncbigene:1616
MAPKAPK2 GeneProduct ncbigene:9261
CASP8 GeneProduct ncbigene:841
PARP1 GeneProduct ncbigene:142
DFFA GeneProduct ncbigene:1676
ARHGDIB GeneProduct ncbigene:397 Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
CYCS GeneProduct ncbigene:54205
FASLG GeneProduct ncbigene:356
CASP8 GeneProduct ncbigene:841
FADD GeneProduct ncbigene:8772
HSPB1 GeneProduct ncbigene:3315
CASP10 GeneProduct ncbigene:843
RB1 GeneProduct ncbigene:5925
ACTA1 GeneProduct ncbigene:58
MAPK8 GeneProduct ncbigene:5599
JUN GeneProduct ncbigene:3725
MAPKAPK3 GeneProduct ncbigene:7867
MAP2K4 GeneProduct ncbigene:6416
CASP6 GeneProduct ncbigene:839
HSPB1 GeneProduct ncbigene:3315
HSPB1 GeneProduct ncbigene:3315
APAF1 GeneProduct ncbigene:317
PAK2 GeneProduct ncbigene:5062
MAP3K7 GeneProduct ncbigene:6885
LMNB1 GeneProduct ncbigene:4001
LMNB2 GeneProduct ncbigene:84823
CASP9 GeneProduct ncbigene:842
DAXX GeneProduct ncbigene:1616
CFLAR GeneProduct ncbigene:8837
BCL2 GeneProduct ncbigene:596
MAP3K1 GeneProduct ncbigene:4214
CASP3 GeneProduct ncbigene:836
CASP3 GeneProduct ncbigene:836
HSPB1 GeneProduct ncbigene:3315
TNF GeneProduct ncbigene:7124
PRKDC GeneProduct ncbigene:5591
FAF1 GeneProduct ncbigene:11124
LMNA GeneProduct ncbigene:4000
FAP1 GeneProduct ncbigene:4799
HSPB1 GeneProduct ncbigene:3315
DFFB GeneProduct ncbigene:1677
FAS GeneProduct ncbigene:355
HSPB1 GeneProduct ncbigene:3315
HSPB1 GeneProduct ncbigene:3315
ACTB GeneProduct ncbigene:60
ACTG1 GeneProduct ncbigene:71

References

  1. Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161–73. PubMed Europe PMC Scholia
  2. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. Ji Q, Hao X, Meng Y, Zhang M, Desano J, Fan D, et al. BMC Cancer. 2008 Sep 21;8:266. PubMed Europe PMC Scholia