Eicosanoid synthesis (WP318)

Mus musculus

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: [[wikipedia:Eicosanoid|Wikipedia]]


Andrew Kwa , Kristina Hanspers , Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz


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Mus musculus



Pathway Ontology

eicosanoid biosynthetic pathway


Label Type Compact URI Comment
5-HETE Metabolite cas:70608-72-9
5-HPETE Metabolite hmdb:HMDB0001193
Prostaglandin H2 Metabolite hmdb:HMDB0001381
Leukotriene D4 Metabolite hmdb:HMDB0003080
Thromboxane B2 Metabolite hmdb:HMDB0003252
Prostaglandin I2 Metabolite hmdb:HMDB0001335
Prostaglandin D2 Metabolite hmdb:HMDB0001403
Leukotriene A4 Metabolite hmdb:HMDB0001337
Prostaglandin F2a Metabolite hmdb:HMDB0001139
Leukotriene C4 Metabolite hmdb:HMDB0001198
Leukotriene E4 Metabolite hmdb:HMDB0002200
Thromboxane A2 Metabolite hmdb:HMDB0001452
Arachidonic acid Metabolite hmdb:HMDB0001043
Leukotriene B4 Metabolite hmdb:HMDB0001085
Alox5ap GeneProduct ncbigene:11690
Ptgds GeneProduct ncbigene:19215
Ptges2 GeneProduct ncbigene:96979
Dpep1 GeneProduct ncbigene:13479
Ptgis GeneProduct ncbigene:19223
Pla2g2a GeneProduct ncbigene:18780
Alox5 GeneProduct ncbigene:11689
Tbxas1 GeneProduct ncbigene:21391
Ptgs1 GeneProduct ncbigene:19224
Ggt1 GeneProduct ncbigene:14598
Pla2g6 GeneProduct ncbigene:53357
Alox15 GeneProduct ncbigene:11687
Alox8 GeneProduct ncbigene:11688
Ptges GeneProduct ncbigene:64292
Pla2g6 GeneProduct ncbigene:53357
Alox5 GeneProduct ncbigene:11689
Lta4h GeneProduct ncbigene:16993
Ptgs2 GeneProduct ncbigene:19225
Ltc4s GeneProduct ncbigene:17001
Alox15 GeneProduct ncbigene:11687
Alox5ap GeneProduct ncbigene:11690
Pnpla8 GeneProduct ncbigene:67452
Alox12 GeneProduct ncbigene:11684


  1. Prostaglandins and leukotrienes: advances in eicosanoid biology. Funk CD. Science. 2001 Nov 30;294(5548):1871–5. PubMed Europe PMC Scholia