FAS pathway and stress induction of HSP regulation (WP571)

Mus musculus

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This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].

Authors

Thomas Kelder , Kristina Hanspers , Christine Chichester , Lauren J. Dupuis , Daniela Digles , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

FasL mediated signaling pathway

Participants

Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
Glutathione Metabolite hmdb:HMDB0000125
Spna2 GeneProduct ncbigene:20740 Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
Il1a GeneProduct ncbigene:16175
Faf1 GeneProduct ncbigene:14084
Casp7 GeneProduct ncbigene:12369
Hspb1 GeneProduct ncbigene:15507
Ripk2 GeneProduct ncbigene:192656 receptor (TNFRSF)-interacting serine-threonine kinase 2
Dffb GeneProduct ncbigene:13368
Pak1 GeneProduct ncbigene:18479
Apaf1 GeneProduct ncbigene:11783
Daxx GeneProduct ncbigene:13163
Mapkapk2 GeneProduct ncbigene:17164
Casp8 GeneProduct ncbigene:12370
Parp1 GeneProduct ncbigene:11545
Dffa GeneProduct ncbigene:13347
Arhgdib GeneProduct ncbigene:11857 Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
Gm10108 GeneProduct ncbigene:670717
Fasl GeneProduct ncbigene:14103
Fadd GeneProduct ncbigene:14082
Rb1 GeneProduct ncbigene:19645
Mapk8 GeneProduct ncbigene:26419
Jun GeneProduct ncbigene:16476
Mapkapk3 GeneProduct ncbigene:102626
Map2k4 GeneProduct ncbigene:26398
Casp6 GeneProduct ncbigene:12368
Pak2 GeneProduct ncbigene:224105
Map3k7 GeneProduct ncbigene:26409
Lmnb1 GeneProduct ncbigene:16906
Lmnb2 GeneProduct ncbigene:16907
Casp9 GeneProduct ncbigene:12371
Cflar GeneProduct ncbigene:12633
Bcl2 GeneProduct ncbigene:12043
Map3k1 GeneProduct ncbigene:26401
Casp3 GeneProduct ncbigene:12367
Tnf GeneProduct ncbigene:21926
Prkdc GeneProduct ncbigene:19090
Lmna GeneProduct ncbigene:16905
FAP-1 GeneProduct ncbigene:19249
Fas GeneProduct ncbigene:14102

References

  1. Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161–73. PubMed Europe PMC Scholia