Monoamine GPCRs (WP58)

Homo sapiens

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [ Monoamine neurotransmitters]


Nathan Salomonis , Alex Pico , Joanna S. Fong , Kristina Hanspers , Thomas Kelder , Zahra Roudbari , Denise Slenter , Egon Willighagen , and Eric Weitz


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Homo sapiens



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Serotonin Metabolite cas:50-67-9
Epinephrine Metabolite hmdb:HMDB0000068
Norepinephrine Metabolite hmdb:HMDB0000216
Acetylcholine Metabolite hmdb:HMDB0000895
Muscarine Metabolite chebi:7034
Histamine Metabolite cas:51-45-6
Dopamine Metabolite cas:62-31-7
HRH1 GeneProduct ncbigene:3269
ADRA2C GeneProduct ncbigene:152
HTR4 GeneProduct ncbigene:3360
DRD3 GeneProduct ncbigene:1814
HRH2 GeneProduct ncbigene:3274
CHRM3 GeneProduct ncbigene:1131
ADRA1A GeneProduct ncbigene:148
DRD5 GeneProduct ncbigene:1816
HTR5B GeneProduct ncbigene:645694
DRD4 GeneProduct ncbigene:1815
ADRB3 GeneProduct ncbigene:155
ADRA1B GeneProduct ncbigene:147
CHRM2 GeneProduct ncbigene:1129
HTR6 GeneProduct ncbigene:3362
HTR1D GeneProduct ncbigene:3352
CHRM1 GeneProduct ncbigene:1128
HTR1E GeneProduct ncbigene:3354
HTR7 GeneProduct ncbigene:3363
CHRM4 GeneProduct ncbigene:1132
DRD2 GeneProduct ncbigene:1813
CHRM5 GeneProduct ncbigene:1133
ADRA2A GeneProduct ncbigene:150
HTR2A GeneProduct ncbigene:3356
HTR1F GeneProduct ncbigene:3355
DRD1 GeneProduct ncbigene:1812
HTR5A GeneProduct ncbigene:3361
ADRB1 GeneProduct ncbigene:153
ADRA2B GeneProduct ncbigene:151
HTR2C GeneProduct ncbigene:3358
HTR2B GeneProduct ncbigene:3357
HTR1A GeneProduct ncbigene:3350
ADRA1D GeneProduct ncbigene:146
HTR1B GeneProduct ncbigene:3351
ADRB2 GeneProduct ncbigene:154