Non-genomic actions of 1,25 dihydroxyvitamin D3 (WP4341)
Homo sapiens
The pathway summarizes the knowlegde on the non-genomic actions of the hormonally active form of vitamin D, 1,25 dihydroxyvitamin D3. It is based the pathway figure published by Hii and Ferrante (Nutrients, 2016).
Authors
Susan Coort and Denise SlenterActivity
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Cited In
- A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection (2020).
- Discovering Common Pathogenic Mechanisms of COVID-19 and Parkinson Disease: An Integrated Bioinformatics Analysis (2022).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
vitamin D signaling pathway signaling pathway| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| PMA | Metabolite | chebi:37537 | |
| 1,25D | Metabolite | hmdb:HMDB0001903 | |
| DAG | Metabolite | lipidmaps:LMGL0201 | |
| 25D | Metabolite | hmdb:HMDB0003550 | |
| AA | Metabolite | hmdb:HMDB0001043 | |
| 25D | Metabolite | hmdb:HMDB0003550 | |
| AA | Metabolite | hmdb:HMDB0001043 | |
| 1,25D | Metabolite | hmdb:HMDB0001903 | |
| CaMK2A | GeneProduct | ensembl:ENSG00000070808 | |
| CaMK2B | GeneProduct | ensembl:ENSG00000058404 | |
| CaMK2G | GeneProduct | ensembl:ENSG00000148660 | |
| PLCB1 | GeneProduct | ensembl:ENSG00000182621 | |
| PLCB2 | GeneProduct | ensembl:ENSG00000137841 | |
| PLCB3 | GeneProduct | ensembl:ENSG00000149782 | |
| PLCB4 | GeneProduct | ensembl:ENSG00000101333 | |
| PLCG1 | GeneProduct | ensembl:ENSG00000187091 | |
| PLCD1 | GeneProduct | ensembl:ENSG00000187091 | |
| PLCD3 | GeneProduct | ensembl:ENSG00000187091 | |
| PLCD4 | GeneProduct | ensembl:ENSG00000187091 | |
| PLCE1 | GeneProduct | ensembl:ENSG00000138193 | |
| TLR2 | GeneProduct | ensembl:ENSG00000137462 | |
| TLR8 | GeneProduct | ensembl:ENSG00000101916 | |
| PRKCE | GeneProduct | ensembl:ENSG00000171132 | |
| PRKCH | GeneProduct | ensembl:ENSG00000027075 | |
| PRKCQ | GeneProduct | ensembl:ENSG00000065675 | |
| PIK3CA | GeneProduct | insdc:ENSG00000121879 | |
| PIK3CB | GeneProduct | insdc:ENSG00000051382 | |
| PIK3CG | GeneProduct | insdc:ENSG00000105851 | |
| PIK3CD | GeneProduct | insdc:ENSG00000171608 | |
| PIK3R1 | GeneProduct | insdc:ENSG00000145675 | |
| PIK3R3 | GeneProduct | insdc:ENSG00000117461 | |
| PIK3R4 | GeneProduct | insdc:ENSG00000196455 | |
| PIK3R5 | GeneProduct | insdc:ENSG00000141506 | |
| PIK3C2A | GeneProduct | insdc:ENSG00000011405 | |
| PIK3C2B | GeneProduct | insdc:ENSG00000133056 | |
| PIK3C2G | GeneProduct | insdc:ENSG00000139144 | |
| AKT1 | GeneProduct | insdc:ENSG00000142208 | |
| AKT2 | GeneProduct | insdc:ENSG00000105221 | |
| AKT3 | GeneProduct | insdc:ENSG00000117020 | |
| RXRB | GeneProduct | ensembl:ENSG00000204231 | |
| STAT1 | GeneProduct | ensembl:ENSG00000115415 | |
| STAT2 | GeneProduct | ensembl:ENSG00000170581 | |
| JAK1 | GeneProduct | ensembl:ENSG00000162434 | |
| IFI44L | GeneProduct | ensembl:ENSG00000137959 | |
| ISG15 | GeneProduct | ensembl:ENSG00000187608 | |
| OAS1 | GeneProduct | ensembl:ENSG00000089127 | |
| OAS2 | GeneProduct | ensembl:ENSG00000111335 | |
| OAS3 | GeneProduct | ensembl:ENSG00000111331 | |
| RSAD2 | GeneProduct | ensembl:ENSG00000134321 | |
| IKK2 | GeneProduct | ensembl:ENSG00000104365 | |
| PIK3R2 | GeneProduct | insdc:ENSG00000105647 | |
| MED1 | GeneProduct | ensembl:ENSG00000125686 | |
| PLA2 | GeneProduct | interpro:IPR001211 | Enzyme family, EC 3.1.1.4 [https://en.wikipedia.org/wiki/Phospholipase_A2] |
| PLCG2 | GeneProduct | ensembl:ENSG00000197943 | |
| IFI27L | GeneProduct | ensembl:ENSG00000119632 | |
| PIK3C3 | GeneProduct | insdc:ENSG00000078142 | |
| CYP27B1 | GeneProduct | ensembl:ENSG00000111012 | |
| SP3 | GeneProduct | ensembl:ENSG00000172845 | |
| PRKCG | GeneProduct | ensembl:ENSG00000126583 | |
| PRKCB | GeneProduct | ensembl:ENSG00000166501 | |
| PRKCA | GeneProduct | ensembl:ENSG00000154229 | |
| RXRG | GeneProduct | ensembl:ENSG00000143171 | |
| CD40LG | GeneProduct | ensembl:ENSG00000102245 | |
| PRKCD | GeneProduct | ensembl:ENSG00000163932 | |
| VDR | GeneProduct | ensembl:ENSG00000111424 | |
| RXRA | GeneProduct | ensembl:ENSG00000186350 | |
| CaMK2D | GeneProduct | ensembl:ENSG00000145349 | |
| ETS1 | GeneProduct | ensembl:ENSG00000134954 | |
| TLR4 | GeneProduct | ensembl:ENSG00000136869 | |
| VDRn | GeneProduct | ensembl:ENSG00000111424 | |
| CD40 | GeneProduct | ensembl:ENSG00000101017 | |
| CYP27B1 | GeneProduct | ensembl:ENSG00000111012 | |
| VDR | GeneProduct | ensembl:ENSG00000111424 | |
| TYK2 | GeneProduct | ensembl:ENSG00000105397 | |
| STAT2 | GeneProduct | ensembl:ENSG00000170581 | |
| STAT1 | GeneProduct | ensembl:ENSG00000115415 | |
| VDRm/n | GeneProduct | ensembl:ENSG00000111424 | |
| VDR | GeneProduct | ensembl:ENSG00000111424 | |
| VDRn | GeneProduct | ensembl:ENSG00000111424 | |
| SP1 | GeneProduct | ensembl:ENSG00000185591 | |
| VDR | GeneProduct | ensembl:ENSG00000111424 | |
| cJUN | GeneProduct | ensembl:ENSG00000177606 | |
| KRAS | GeneProduct | ensembl:ENSG00000133703 | |
| HRAS | GeneProduct | ensembl:ENSG00000174775 | |
| NRAS | GeneProduct | ensembl:ENSG00000213281 | |
| MAPK3 | GeneProduct | ensembl:ENSG00000102882 | |
| MAPK1 | GeneProduct | ensembl:ENSG00000100030 | |
| MAPK7 | GeneProduct | ensembl:ENSG00000166484 | |
| MAPK8 | GeneProduct | ensembl:ENSG00000107643 | |
| MAPK9 | GeneProduct | ensembl:ENSG00000050748 | |
| PKC zeta | GeneProduct | ensembl:ENSG00000067606 | |
| VDRn | GeneProduct | ensembl:ENSG00000111424 | |
| NFKB1 | GeneProduct | ensembl:ENSG00000109320 | |
| RELB | GeneProduct | ensembl:ENSG00000104856 | |
| NFKB2 | GeneProduct | ensembl:ENSG00000077150 | |
| NFKB1 | GeneProduct | ensembl:ENSG00000109320 | |
| RELB | GeneProduct | ensembl:ENSG00000104856 | |
| NFKB2 | GeneProduct | ensembl:ENSG00000077150 | |
| MAPK8 | GeneProduct | ensembl:ENSG00000107643 | |
| MAPK9 | GeneProduct | ensembl:ENSG00000050748 | |
| TNFR1 | GeneProduct | ensembl:ENSG00000067182 | |
| TNF | GeneProduct | ensembl:ENSG00000232810 | |
| MAPK11 | GeneProduct | ensembl:ENSG00000185386 | |
| MAPK14 | GeneProduct | ensembl:ENSG00000112062 | |
| MAPK13 | GeneProduct | ensembl:ENSG00000156711 | |
| MAPK12 | GeneProduct | ensembl:ENSG00000188130 | |
| MAPK11 | GeneProduct | ensembl:ENSG00000185386 | |
| MAPK14 | GeneProduct | ensembl:ENSG00000112062 | |
| MAPK13 | GeneProduct | ensembl:ENSG00000156711 | |
| MAPK12 | GeneProduct | ensembl:ENSG00000188130 | |
| CYP24A1 | GeneProduct | ensembl:ENSG00000019186 | |
| CAMP | GeneProduct | ensembl:ENSG00000164047 | |
| DEFB4A | GeneProduct | ensembl:ENSG00000171711 | |
| NOD2 | GeneProduct | ensembl:ENSG00000167207 | |
| VDR | GeneProduct | ensembl:ENSG00000111424 | |
| CCL2 | GeneProduct | ensembl:ENSG00000108691 | |
| CXCL8 | GeneProduct | ensembl:ENSG00000169429 | |
| IL-6 | GeneProduct | ensembl:ENSG00000136244 | |
| Caveolin-1 | Protein | uniprot:Q03135 | |
| IFNR gamma 1 | Protein | uniprot:P15260 | The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains |
| IFN gamma | Protein | uniprot:P01579 | |
| IFN alpha | Protein | uniprot:P01563 | |
| IFNR alpha | Protein | uniprot:P48551 | AKA interferon-α/β receptor (IFNAR) |
| IFNR gamma 2 | Protein | uniprot:P38484 | The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains |
References
- The Non-Genomic Actions of Vitamin D. Hii CS, Ferrante A. Nutrients. 2016 Mar 2;8(3):135. PubMed Europe PMC Scholia