Non-genomic actions of 1,25-dihydroxyvitamin D3 (WP4341)
Homo sapiens
The pathway summarizes non-genomic actions of the hormonally active form of vitamin D: 1,25-dihydroxyvitamin D3. It is based the pathway figure published by Hii and Ferrante (Nutrients, 2016).
For a description of pathway objects, see the WikiPathways Legend.
Authors
Susan Coort , Denise Slenter , Eric Weitz , and Egon WillighagenActivity
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Cited In
- A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection (2020).
- Discovering Common Pathogenic Mechanisms of COVID-19 and Parkinson Disease: An Integrated Bioinformatics Analysis (2022).
- In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).
- Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 (2022).
- Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations (2024).
- Decoding the transcriptome from bulk RNA of infection-naïve versus imprinted patients with SARS-CoV-2 Omicron B.1.1.529 (2025).
- Dysregulated vitamin D signaling in Hashimoto's thyroiditis: an integrated transcriptomic study in a Korean cohort (2025).
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Organisms
Homo sapiensCommunities
Serious Request 2024 - MetaKidsAnnotations
Pathway Ontology
vitamin D signaling pathway signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PMA | Metabolite | chebi:37537 | |
| 1,25D | Metabolite | hmdb:HMDB0001903 | |
| DAG | Metabolite | lipidmaps:LMGL0201 | |
| 25D | Metabolite | hmdb:HMDB0003550 | |
| AA | Metabolite | hmdb:HMDB0001043 | |
| CaMK2A | GeneProduct | ensembl:ENSG00000070808 | |
| CaMK2B | GeneProduct | ensembl:ENSG00000058404 | |
| CaMK2G | GeneProduct | ensembl:ENSG00000148660 | |
| PLCB1 | GeneProduct | ensembl:ENSG00000182621 | |
| PLCB2 | GeneProduct | ensembl:ENSG00000137841 | |
| PLCB3 | GeneProduct | ensembl:ENSG00000149782 | |
| PLCB4 | GeneProduct | ensembl:ENSG00000101333 | |
| PLCG1 | GeneProduct | ensembl:ENSG00000187091 | |
| PLCD1 | GeneProduct | ensembl:ENSG00000187091 | |
| PLCD3 | GeneProduct | ensembl:ENSG00000187091 | |
| PLCD4 | GeneProduct | ensembl:ENSG00000187091 | |
| PLCE1 | GeneProduct | ensembl:ENSG00000138193 | |
| TLR2 | GeneProduct | ensembl:ENSG00000137462 | |
| TLR8 | GeneProduct | ensembl:ENSG00000101916 | |
| PRKCE | GeneProduct | ensembl:ENSG00000171132 | |
| PRKCH | GeneProduct | ensembl:ENSG00000027075 | |
| PRKCQ | GeneProduct | ensembl:ENSG00000065675 | |
| PIK3CA | GeneProduct | insdc:ENSG00000121879 | |
| PIK3CB | GeneProduct | insdc:ENSG00000051382 | |
| PIK3CG | GeneProduct | insdc:ENSG00000105851 | |
| PIK3CD | GeneProduct | insdc:ENSG00000171608 | |
| PIK3R1 | GeneProduct | insdc:ENSG00000145675 | |
| PIK3R3 | GeneProduct | insdc:ENSG00000117461 | |
| PIK3R4 | GeneProduct | insdc:ENSG00000196455 | |
| PIK3R5 | GeneProduct | insdc:ENSG00000141506 | |
| PIK3C2A | GeneProduct | insdc:ENSG00000011405 | |
| PIK3C2B | GeneProduct | insdc:ENSG00000133056 | |
| PIK3C2G | GeneProduct | insdc:ENSG00000139144 | |
| AKT1 | GeneProduct | insdc:ENSG00000142208 | |
| AKT2 | GeneProduct | insdc:ENSG00000105221 | |
| AKT3 | GeneProduct | insdc:ENSG00000117020 | |
| RXRB | GeneProduct | ensembl:ENSG00000204231 | |
| STAT1 | GeneProduct | ensembl:ENSG00000115415 | |
| STAT2 | GeneProduct | ensembl:ENSG00000170581 | |
| JAK1 | GeneProduct | ensembl:ENSG00000162434 | |
| IFI44L | GeneProduct | ensembl:ENSG00000137959 | |
| ISG15 | GeneProduct | ensembl:ENSG00000187608 | |
| OAS1 | GeneProduct | ensembl:ENSG00000089127 | |
| OAS2 | GeneProduct | ensembl:ENSG00000111335 | |
| OAS3 | GeneProduct | ensembl:ENSG00000111331 | |
| RSAD2 | GeneProduct | ensembl:ENSG00000134321 | |
| IKK2 | GeneProduct | ensembl:ENSG00000104365 | |
| PIK3R2 | GeneProduct | insdc:ENSG00000105647 | |
| MED1 | GeneProduct | ensembl:ENSG00000125686 | |
| PLA2 | GeneProduct | interpro:IPR001211 | Enzyme family, EC 3.1.1.4 [https://en.wikipedia.org/wiki/Phospholipase_A2] |
| PLCG2 | GeneProduct | ensembl:ENSG00000197943 | |
| IFI27L | GeneProduct | ensembl:ENSG00000119632 | |
| PIK3C3 | GeneProduct | insdc:ENSG00000078142 | |
| CYP27B1 | GeneProduct | ensembl:ENSG00000111012 | |
| SP3 | GeneProduct | ensembl:ENSG00000172845 | |
| PRKCG | GeneProduct | ensembl:ENSG00000126583 | |
| PRKCB | GeneProduct | ensembl:ENSG00000166501 | |
| PRKCA | GeneProduct | ensembl:ENSG00000154229 | |
| RXRG | GeneProduct | ensembl:ENSG00000143171 | |
| CD40LG | GeneProduct | ensembl:ENSG00000102245 | |
| PRKCD | GeneProduct | ensembl:ENSG00000163932 | |
| VDR | GeneProduct | ensembl:ENSG00000111424 | |
| RXRA | GeneProduct | ensembl:ENSG00000186350 | |
| CaMK2D | GeneProduct | ensembl:ENSG00000145349 | |
| ETS1 | GeneProduct | ensembl:ENSG00000134954 | |
| TLR4 | GeneProduct | ensembl:ENSG00000136869 | |
| VDRn | GeneProduct | ensembl:ENSG00000111424 | |
| CD40 | GeneProduct | ensembl:ENSG00000101017 | |
| TYK2 | GeneProduct | ensembl:ENSG00000105397 | |
| VDRm/n | GeneProduct | ensembl:ENSG00000111424 | |
| SP1 | GeneProduct | ensembl:ENSG00000185591 | |
| cJUN | GeneProduct | ensembl:ENSG00000177606 | |
| KRAS | GeneProduct | ensembl:ENSG00000133703 | |
| HRAS | GeneProduct | ensembl:ENSG00000174775 | |
| NRAS | GeneProduct | ensembl:ENSG00000213281 | |
| MAPK3 | GeneProduct | ensembl:ENSG00000102882 | |
| MAPK1 | GeneProduct | ensembl:ENSG00000100030 | |
| MAPK7 | GeneProduct | ensembl:ENSG00000166484 | |
| MAPK8 | GeneProduct | ensembl:ENSG00000107643 | |
| MAPK9 | GeneProduct | ensembl:ENSG00000050748 | |
| PKC zeta | GeneProduct | ensembl:ENSG00000067606 | |
| NFKB1 | GeneProduct | ensembl:ENSG00000109320 | |
| RELB | GeneProduct | ensembl:ENSG00000104856 | |
| NFKB2 | GeneProduct | ensembl:ENSG00000077150 | |
| TNFR1 | GeneProduct | ensembl:ENSG00000067182 | |
| TNF | GeneProduct | ensembl:ENSG00000232810 | |
| MAPK11 | GeneProduct | ensembl:ENSG00000185386 | |
| MAPK14 | GeneProduct | ensembl:ENSG00000112062 | |
| MAPK13 | GeneProduct | ensembl:ENSG00000156711 | |
| MAPK12 | GeneProduct | ensembl:ENSG00000188130 | |
| CYP24A1 | GeneProduct | ensembl:ENSG00000019186 | |
| CAMP | GeneProduct | ensembl:ENSG00000164047 | |
| DEFB4A | GeneProduct | ensembl:ENSG00000171711 | |
| NOD2 | GeneProduct | ensembl:ENSG00000167207 | |
| CCL2 | GeneProduct | ensembl:ENSG00000108691 | |
| CXCL8 | GeneProduct | ensembl:ENSG00000169429 | |
| IL-6 | GeneProduct | ensembl:ENSG00000136244 | |
| Caveolin-1 | Protein | uniprot:Q03135 | |
| IFNR gamma 1 | Protein | uniprot:P15260 | The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains |
| IFN gamma | Protein | uniprot:P01579 | |
| IFN alpha | Protein | uniprot:P01563 | |
| IFNR alpha | Protein | uniprot:P48551 | AKA interferon-α/β receptor (IFNAR) |
| IFNR gamma 2 | Protein | uniprot:P38484 | The IFN-γ receptor (IFNGR) is a heterodimeric receptor composed of the IFNGR-1 (α chain) and IFNGR-2 (β chain) chains |
References
- The Non-Genomic Actions of Vitamin D. Hii CS, Ferrante A. Nutrients. 2016 Mar 2;8(3):135. PubMed Europe PMC Scholia