Pyruvate dehydrogenase pathway (WP214)

Saccharomyces cerevisiae

Pyruvate dehydrogenase is a multiple enzyme complex that catalyzes the production of acetyl-CoA from pyruvate produced by glycolysis. The final step re-oxidizes the lipoyl group of dihydrolipoamide to form lipoamide and NADH.


Jessica Heckman , Daniela Digles , Egon Willighagen , Max Van Son , Eric Weitz , and Alex Pico


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Saccharomyces cerevisiae



Pathway Ontology

pyruvate metabolic pathway


Label Type Compact URI Comment
NAD Metabolite chebi:13389
S-Acetyldihydrolipoamide Metabolite hmdb:HMDB0001526
pyruvate Metabolite chebi:15361
Coenzyme A Metabolite cas:64885-97-8
NADH Metabolite cas:53-84-9
lipoamide Metabolite cas:940-69-2
lipoamide Metabolite cas:940-69-2
acetyl-CoA Metabolite cas:72-89-9
dihydrolipoamide Metabolite cas:3884-47-7
PDA1 GeneProduct sgd:S000000980
PDB1 GeneProduct sgd:S000000425
LPD1 GeneProduct sgd:S000001876
LAT1 GeneProduct sgd:S000005015