Statin pathway (WP1)

Mus musculus

Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [ PharmGKB] and [ Wikipedia]


Nathan Salomonis , Kristina Hanspers , Bruce Conklin , Alex Pico , Thomas Kelder , Martina Summer-Kutmon , Andra Waagmeester , Egon Willighagen , Daniela Digles , and Eric Weitz


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Mus musculus



Pathway Ontology

statin drug pathway hypercholesterolemia pathway

Disease Ontology

cardiovascular system disease

Cell Type Ontology



Label Type Compact URI Comment
Triglycerides Metabolite chebi:17855
Phospholipid Metabolite chebi:16247
Fatty acid Metabolite chebi:35366
Cholesterol ester Metabolite chebi:17002
Cholesterol Metabolite hmdb:HMDB0000067
Statin Metabolite chebi:87631
Cholic acid Metabolite hmdb:HMDB0000619
Acetyl-CoA Metabolite hmdb:HMDB0001206
Lrp1 GeneProduct ncbigene:16971
Apoc3 GeneProduct ncbigene:11814
Apoc2 GeneProduct ncbigene:11813
Lipc GeneProduct ncbigene:15450
Cetp GeneProduct ncbigene:1071
Apoa4 GeneProduct ncbigene:11808
Dgat1 GeneProduct ncbigene:13350
Lpl GeneProduct ncbigene:16956
Scarb1 GeneProduct ncbigene:20778
Pltp GeneProduct ncbigene:18830
Ldlr GeneProduct ncbigene:16835
Abca1 GeneProduct ncbigene:11303
Cyp7a1 GeneProduct ncbigene:13122
Hmgcr GeneProduct ncbigene:15357
Apoa1 GeneProduct ncbigene:11806
Soat1 GeneProduct ncbigene:20652
Lcat GeneProduct ncbigene:16816
Mttp GeneProduct ncbigene:17777
Apoc1 GeneProduct ncbigene:11812
Apoe GeneProduct ncbigene:11816


  1. Direct effects of statins on cells primarily involved in atherosclerosis. Chen H, Ikeda U, Shimpo M, Shimada K. Hypertens Res. 2000 Mar;23(2):187–92. PubMed Europe PMC Scholia