MAPK signaling pathway (WP358)

Rattus norvegicus

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Authors

Sebastien Burel , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway

Participants

Label Type Compact URI Comment
LPS Metabolite chebi:16412
IP3 Metabolite chebi:16595
Ca2+ Metabolite hmdb:HMDB0000464
cAMP Metabolite hmdb:HMDB0000058
DAG Metabolite chebi:18035
Traf6 GeneProduct ensembl:ENSRNOG00000004639 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7189
Mef2c GeneProduct ensembl:ENSRNOG00000033134 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4208
Srf GeneProduct ensembl:ENSRNOG00000018232 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6722
Rps6ka3 GeneProduct ensembl:ENSRNOG00000006632 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6197
Map2k3 GeneProduct ensembl:ENSRNOG00000049132 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5606
Elk4 GeneProduct ensembl:ENSRNOG00000007887 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000158711
Rap1a GeneProduct ensembl:ENSRNOG00000032463 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5906
Crk GeneProduct ensembl:ENSRNOG00000025792 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1398
Il1a GeneProduct ensembl:ENSRNOG00000004575 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3552
Pdgfb GeneProduct ensembl:ENSRNOG00000017197 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5155
Akt3 GeneProduct ensembl:ENSRNOG00000021497 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10000
Ecsit GeneProduct ensembl:ENSRNOG00000014128 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51295
Map3k13 GeneProduct ensembl:ENSRNOG00000025423 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9175
Rasgrp4 GeneProduct ensembl:ENSRNOG00000033744 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:115727
LOC100910771 GeneProduct ensembl:ENSRNOG00000005724 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6885
Mapk9 GeneProduct ensembl:ENSRNOG00000002823 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5601
Grb2 GeneProduct ensembl:ENSRNOG00000003990 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2885
Mknk1 GeneProduct ensembl:ENSRNOG00000010381 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8569
Dusp1 GeneProduct ensembl:ENSRNOG00000003977 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1843
Stmn1 GeneProduct ensembl:ENSRNOG00000016810 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3925
Elk1 GeneProduct ensembl:ENSRNOG00000010171 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2002
Egfr GeneProduct ensembl:ENSRNOG00000004332 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1956
Ppp3cb GeneProduct ensembl:ENSRNOG00000054782 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5532
Ppp3cc GeneProduct ensembl:ENSRNOG00000009745 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5533
Map4k1 GeneProduct ensembl:ENSRNOG00000020505 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11184
Nfatc1 GeneProduct ensembl:ENSRNOG00000017146 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4772
Arrb2 GeneProduct ensembl:ENSRNOG00000019308 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:409
Mapt GeneProduct ensembl:ENSRNOG00000005133 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4137
Rasgrp1 GeneProduct ensembl:ENSRNOG00000005404 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10125
Rap1b GeneProduct ensembl:ENSRNOG00000007048 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5908
Cd14 GeneProduct ensembl:ENSRNOG00000017819 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:929
Ikbkg GeneProduct ensembl:ENSRNOG00000060936 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8517
Bdnf GeneProduct ensembl:ENSRNOG00000047466 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:627
Daxx GeneProduct ensembl:ENSRNOG00000000477 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1616
Mapk10 GeneProduct ensembl:ENSRNOG00000002079 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5602
LOC103694380 GeneProduct ensembl:ENSRNOG00000000837 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7124
Mos GeneProduct ensembl:ENSRNOG00000008567 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4342
Stk4 GeneProduct ensembl:ENSRNOG00000013529 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000101109
Mapk14 GeneProduct ensembl:ENSRNOG00000000513 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1432
Ikbkb GeneProduct ensembl:ENSRNOG00000019073 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3551
Arrb1 GeneProduct ensembl:ENSRNOG00000030404 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:408
Lrrk2 GeneProduct ensembl:ENSRNOG00000004048 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000188906
Casp3 GeneProduct ensembl:ENSRNOG00000010475 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:836
Flna GeneProduct ensembl:ENSRNOG00000054890 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2316
Mapkapk2 GeneProduct ensembl:ENSRNOG00000004726 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9261
Tnfrsf1a GeneProduct ensembl:ENSRNOG00000031312 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000067182
Map3k14 GeneProduct ensembl:ENSRNOG00000003278 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000006062
Hspb1 GeneProduct ensembl:ENSRNOG00000023546 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3315
Map3k20 GeneProduct ensembl:ENSRNOG00000001515 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51776
Gna12 GeneProduct ensembl:ENSRNOG00000001235 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2768
Tgfb1 GeneProduct ensembl:ENSRNOG00000020652 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7040
LOC100912399 GeneProduct ensembl:ENSRNOG00000013177 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4214
Map3k2 GeneProduct ensembl:ENSRNOG00000014089 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10746
Max GeneProduct ensembl:ENSRNOG00000008049 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4149
Dusp10 GeneProduct ensembl:ENSRNOG00000004003 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11221
RASGRF2 GeneProduct ensembl:ENSRNOG00000056151 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5924
Map4k4 GeneProduct ensembl:ENSRNOG00000014013 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9448
Pdgfrb GeneProduct ensembl:ENSRNOG00000018461 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5159
Tab1 GeneProduct ensembl:ENSRNOG00000017285 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10454
Map3k4 GeneProduct ensembl:ENSRNOG00000017419 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4216
Gadd45a GeneProduct ensembl:ENSRNOG00000005615 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1647
Map2k5 GeneProduct ensembl:ENSRNOG00000007926 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5607
Cdc25b GeneProduct ensembl:ENSRNOG00000021248 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:994
Il1r1 GeneProduct ensembl:ENSRNOG00000014504 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3554
Rac2 GeneProduct ensembl:ENSRNOG00000007350 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5880
Prkcd GeneProduct ensembl:ENSRNOG00000016346 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5580
Ppp5c GeneProduct ensembl:ENSRNOG00000016907 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5536
Map2k1 GeneProduct ensembl:ENSRNOG00000010176 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5604
Rac1 GeneProduct ensembl:ENSRNOG00000001068 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5879
Ptpn7 GeneProduct ensembl:ENSRNOG00000005807 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5778
Il1r2 GeneProduct ensembl:ENSRNOG00000014378 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7850
Tab2 GeneProduct ensembl:ENSRNOG00000016054 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23118
Tgfbr1 GeneProduct ensembl:ENSRNOG00000007036 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7046
Mapk1 GeneProduct ensembl:ENSRNOG00000001849 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5594
Ptprr GeneProduct ensembl:ENSRNOG00000004483 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5801
Ptpn5 GeneProduct ensembl:ENSRNOG00000013981 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:84867
Pla2g4d GeneProduct ensembl:ENSRNOG00000037231 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000159337
Braf GeneProduct ensembl:ENSRNOG00000010957 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:673
Ntrk1 GeneProduct ensembl:ENSRNOG00000013953 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4914
Atf2 GeneProduct ensembl:ENSRNOG00000001597 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1386
Map2k4 GeneProduct ensembl:ENSRNOG00000003834 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6416
Fos GeneProduct ensembl:ENSRNOG00000008015 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2353
Prkcg GeneProduct ensembl:ENSRNOG00000054371 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5582
Myc GeneProduct ensembl:ENSRNOG00000004500 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4609
Sos2 GeneProduct ensembl:ENSRNOG00000004826 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6655
Tgfb2 GeneProduct ensembl:ENSRNOG00000002418 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7042
LOC100912585 GeneProduct ensembl:ENSRNOG00000002412 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5598
Dusp4 GeneProduct ensembl:ENSRNOG00000011921 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1846
Cacng3 GeneProduct ensembl:ENSRNOG00000012362 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = H:CACNG3
Hspa8 GeneProduct ensembl:ENSRNOG00000032585 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3312
Mapk12 GeneProduct ensembl:ENSRNOG00000031233 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6300
Mapk8ip1 GeneProduct ensembl:ENSRNOG00000058478 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000121653
Ppm1a GeneProduct ensembl:ENSRNOG00000005916 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5494
Il1b GeneProduct ensembl:ENSRNOG00000004649 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3553
Traf2 GeneProduct ensembl:ENSRNOG00000006238 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7186
Mapk13 GeneProduct ensembl:ENSRNOG00000000515 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5603
Taok1 GeneProduct ensembl:ENSRNOG00000015692 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:57551
Map2k6 GeneProduct ensembl:ENSRNOG00000004437 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5608
Dusp8 GeneProduct ensembl:ENSRNOG00000029394 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000184545
Akt2 GeneProduct ensembl:ENSRNOG00000018677 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:208
Mapkapk5 GeneProduct ensembl:ENSRNOG00000001345 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8550
Rasa2 GeneProduct ensembl:ENSRNOG00000011909 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5922
Dusp7 GeneProduct ensembl:ENSRNOG00000010789 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1849
Ppp3r2 GeneProduct ensembl:ENSRNOG00000005368 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5535
Fgfr1 GeneProduct ensembl:ENSRNOG00000016050 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2260
Tgfb3 GeneProduct ensembl:ENSRNOG00000009867 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7043
Ppp3ca GeneProduct ensembl:ENSRNOG00000009882 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5530
Egf GeneProduct ensembl:ENSRNOG00000053979 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1950
Ddit3 GeneProduct ensembl:ENSRNOG00000006789 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1649
Map3k6 GeneProduct ensembl:ENSRNOG00000008936 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9064
Map3k8 GeneProduct ensembl:ENSRNOG00000016378 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1326
Ngf GeneProduct ensembl:ENSRNOG00000016571 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000134259
LOC100911248 GeneProduct ensembl:ENSRNOG00000001868 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1399
Taok2 GeneProduct ensembl:ENSRNOG00000019964 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9344
Mapk3 GeneProduct ensembl:ENSRNOG00000053583 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5595
Mapk8 GeneProduct ensembl:ENSRNOG00000020155 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5599
Nr4a1 GeneProduct ensembl:ENSRNOG00000007607 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3164
Prkca GeneProduct ensembl:ENSRNOG00000003491 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000154229
Atf4 GeneProduct ensembl:ENSRNOG00000017801 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:468
Ntf4 GeneProduct ensembl:ENSRNOG00000020783 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000225950
Pdgfa GeneProduct ensembl:ENSRNOG00000001312 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000197461
Ntrk2 GeneProduct ensembl:ENSRNOG00000018839 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000148053
Faslg GeneProduct ensembl:ENSRNOG00000002978 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:356
Pdgfrb GeneProduct ensembl:ENSRNOG00000018461 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000113721
Ppm1b GeneProduct ensembl:ENSRNOG00000030667 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5495
Fgfr2 GeneProduct ensembl:ENSRNOG00000016374 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000066468
Cdc42 GeneProduct ensembl:ENSRNOG00000013536 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:998
Fgfr3 GeneProduct ensembl:ENSRNOG00000016818 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000068078
Lamtor3 GeneProduct ensembl:ENSRNOG00000010552 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8649
Fgfr4 GeneProduct ensembl:ENSRNOG00000016763 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000160867
Jun GeneProduct ensembl:ENSRNOG00000026293 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3725
Sos1 GeneProduct ensembl:ENSRNOG00000007106 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000115904
Jund GeneProduct ensembl:ENSRNOG00000019568 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3727
Rras GeneProduct ensembl:ENSRNOG00000037247 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000126458
Hras GeneProduct ensembl:ENSRNOG00000016611 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000174775
Rps6ka5 GeneProduct ensembl:ENSRNOG00000004362 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9252
Map3k12 GeneProduct ensembl:ENSRNOG00000015134 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7786
Tp53 GeneProduct ensembl:ENSRNOG00000010756 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7157
Rras2 GeneProduct ensembl:ENSRNOG00000012258 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000133818
Nfkb1 GeneProduct ensembl:ENSRNOG00000023258 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4790
Gng12 GeneProduct ensembl:ENSRNOG00000050231 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000172380
Pla2g4c GeneProduct ensembl:ENSRNOG00000026764 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000105499
Nf1 GeneProduct ensembl:ENSRNOG00000013780 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000196712
Rasgrp2 GeneProduct ensembl:ENSRNOG00000021098 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000068831
Akt1 GeneProduct ensembl:ENSRNOG00000028629 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:207
Rasgrp3 GeneProduct ensembl:ENSRNOG00000032703 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000152689
Rasgrp4 GeneProduct ensembl:ENSRNOG00000033744 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000171777
Rasa1 GeneProduct ensembl:ENSRNOG00000029185 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5921
Rasgrf1 GeneProduct ensembl:ENSRNOG00000014025 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000058335
Ntf3 GeneProduct ensembl:ENSRNOG00000019716 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000185652
Rapgef2 GeneProduct ensembl:ENSRNOG00000021581 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000109756
Prkacb GeneProduct ensembl:ENSRNOG00000004978 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000142875
Hspa1a GeneProduct ensembl:ENSRNOG00000045654 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3303
Prkaca GeneProduct ensembl:ENSRNOG00000005257 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000165059
Stk3 GeneProduct ensembl:ENSRNOG00000011278 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6788
Dusp3 GeneProduct ensembl:ENSRNOG00000036798 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000108861
Map4k3 GeneProduct ensembl:ENSRNOG00000007172 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8491
Chuk GeneProduct ensembl:ENSRNOG00000022485 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000213341
Tgfbr2 GeneProduct ensembl:ENSRNOG00000013265 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7048
Nfkb2 GeneProduct ensembl:ENSRNOG00000019311 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000077150
Map4k2 GeneProduct ensembl:ENSRNOG00000021061 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000168067
Rela GeneProduct ensembl:ENSRNOG00000030888 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000173039
Map2k7 GeneProduct ensembl:ENSRNOG00000001047 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5609
Relb GeneProduct ensembl:ENSRNOG00000033235 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000104856
Dusp9 GeneProduct ensembl:ENSRNOG00000055185 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000130829
Nlk GeneProduct ensembl:ENSRNOG00000008704 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51701
Dusp2 GeneProduct ensembl:ENSRNOG00000013862 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000158050
Dusp16 GeneProduct ensembl:ENSRNOG00000006628 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000111266
Fas GeneProduct ensembl:ENSRNOG00000019142 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:355
Mknk2 GeneProduct ensembl:ENSRNOG00000029028 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000099875
Pla2g4a GeneProduct ensembl:ENSRNOG00000002657 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000116711
Nfatc3 GeneProduct ensembl:ENSRNOG00000054264 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000072736
Map3k5 GeneProduct ensembl:ENSRNOG00000031700 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4217
Map3k11 GeneProduct ensembl:ENSRNOG00000020773 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4296
Taok3 GeneProduct ensembl:ENSRNOG00000001138 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000135090
Dusp6 GeneProduct ensembl:ENSRNOG00000023896 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1848
Map2k2 GeneProduct ensembl:ENSRNOG00000020005 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5605
Mapk11 GeneProduct ensembl:ENSRNOG00000006984 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000185386
Rps6ka4 GeneProduct ensembl:ENSRNOG00000021117 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000162302
Mapkapk3 GeneProduct ensembl:ENSRNOG00000014832 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000114738
Rac3 GeneProduct ensembl:ENSRNOG00000048172 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000169750
Mapk8ip2 GeneProduct ensembl:ENSRNOG00000032828 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000008735
Mapk8ip3 GeneProduct ensembl:ENSRNOG00000033568 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000138834
Flnb GeneProduct ensembl:ENSRNOG00000009470 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000136068
Flnc GeneProduct ensembl:ENSRNOG00000007281 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000128591
Hspa1a GeneProduct ensembl:ENSRNOG00000045654 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000204388
Hspa1l GeneProduct ensembl:ENSRNOG00000047966 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000204390
Hspa2 GeneProduct ensembl:ENSRNOG00000006472 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000126803
Mras GeneProduct ensembl:ENSRNOG00000014060 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:22808
Nras GeneProduct ensembl:ENSRNOG00000023079 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4893
Kras GeneProduct ensembl:ENSRNOG00000009338 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3845
Raf1 GeneProduct ensembl:ENSRNOG00000010153 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5894
Pla2g4f GeneProduct ensembl:ENSRNOG00000008135 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000168907
Pla2g4b GeneProduct ensembl:ENSRNOG00000007447 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000243708
Pla2g4e GeneProduct ensembl:ENSRNOG00000024904 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000188089
Cacng2 GeneProduct ensembl:ENSRNOG00000006226 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000166862
Cacng5 GeneProduct ensembl:ENSRNOG00000003288 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000075429
Cacng4 GeneProduct ensembl:ENSRNOG00000003262 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000075461
Cacna2d3 GeneProduct ensembl:ENSRNOG00000031287 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000157445
Cacng8 GeneProduct ensembl:ENSRNOG00000057848 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000142408
Cacng7 GeneProduct ensembl:ENSRNOG00000056257 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000105605
Cacng6 GeneProduct ensembl:ENSRNOG00000057852 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000130433
Cacna1a GeneProduct ensembl:ENSRNOG00000052707 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000141837
Cacna1b GeneProduct ensembl:ENSRNOG00000004560 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000148408
Cacna1c GeneProduct ensembl:ENSRNOG00000007090 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000151067
Cacna1d GeneProduct ensembl:ENSRNOG00000013147 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000157388
Cacna1e GeneProduct ensembl:ENSRNOG00000002863 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000198216
Cacna1f GeneProduct ensembl:ENSRNOG00000010348 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000102001
Cacna1s GeneProduct ensembl:ENSRNOG00000046231 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000081248
Cacna2d1 GeneProduct ensembl:ENSRNOG00000033531 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000153956
Cacnb1 GeneProduct ensembl:ENSRNOG00000004518 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000067191
Cacnb2 GeneProduct ensembl:ENSRNOG00000018378 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000165995
Cacnb3 GeneProduct ensembl:ENSRNOG00000054274 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000167535
Cacnb4 GeneProduct ensembl:ENSRNOG00000007666 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000182389
Cacng1 GeneProduct ensembl:ENSRNOG00000003245 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000108878
Cacna1h GeneProduct ensembl:ENSRNOG00000033893 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000196557
Cacna1g GeneProduct ensembl:ENSRNOG00000060528 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000006283
Cacna2d2 GeneProduct ensembl:ENSRNOG00000015835 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000007402
Cacna2d4 GeneProduct ensembl:ENSRNOG00000008031 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000151062
Fgf4 GeneProduct ensembl:ENSRNOG00000020890 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2249
Fgf1 GeneProduct ensembl:ENSRNOG00000013867 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000113578
Fgf2 GeneProduct ensembl:ENSRNOG00000017392 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000138685
Fgf3 GeneProduct ensembl:ENSRNOG00000020888 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000186895
Fgf4 GeneProduct ensembl:ENSRNOG00000020890 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000075388
Fgf5 GeneProduct ensembl:ENSRNOG00000022631 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000138675
Fgf6 GeneProduct ensembl:ENSRNOG00000053662 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000111241
Fgf7 GeneProduct ensembl:ENSRNOG00000009425 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000140285
Fgf8 GeneProduct ensembl:ENSRNOG00000017524 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000107831
Fgf9 GeneProduct ensembl:ENSRNOG00000011471 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000102678
Fgf10 GeneProduct ensembl:ENSRNOG00000012278 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000070193
Fgf11 GeneProduct ensembl:ENSRNOG00000014882 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000161958
Fgf12 GeneProduct ensembl:ENSRNOG00000001931 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000114279
Fgf13 GeneProduct ensembl:ENSRNOG00000042753 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000129682
Fgf14 GeneProduct ensembl:ENSRNOG00000009288 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000102466
Fgf20 GeneProduct ensembl:ENSRNOG00000000109 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000078579
Fgf21 GeneProduct ensembl:ENSRNOG00000020990 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000105550
Fgf22 GeneProduct ensembl:ENSRNOG00000008960 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000070388
Fgf23 GeneProduct ensembl:ENSRNOG00000052205 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000118972
Fgf18 GeneProduct ensembl:ENSRNOG00000048389 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000156427
Fgf17 GeneProduct ensembl:ENSRNOG00000012912 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000158815
Fgf16 GeneProduct ensembl:ENSRNOG00000061530 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000196468
Fgf19 GeneProduct ensembl:ENSRNOG00000020899 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000162344
Pak2 GeneProduct ensembl:ENSRNOG00000001747 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5062
Pak1 GeneProduct ensembl:ENSRNOG00000029784 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5058

References

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  3. Docking interactions in the mitogen-activated protein kinase cascades. Tanoue T, Nishida E. Pharmacol Ther. 2002;93(2–3):193–202. PubMed Europe PMC Scholia
  4. Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system. Takeda K, Ichijo H. Genes Cells. 2002 Nov;7(11):1099–111. PubMed Europe PMC Scholia
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  8. MAPK pathways in radiation responses. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S. Oncogene. 2003 Sep 1;22(37):5885–96. PubMed Europe PMC Scholia
  9. Transcriptional regulation by the MAP kinase signaling cascades. Yang SH, Sharrocks AD, Whitmarsh AJ. Gene. 2003 Nov 27;320:3–21. PubMed Europe PMC Scholia
  10. MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta. Abell AN, Granger DA, Johnson GL. J Biol Chem. 2007 Oct 19;282(42):30476–84. PubMed Europe PMC Scholia
  11. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, et al. Cell Death Differ. 2012 Oct;19(10):1623–33. PubMed Europe PMC Scholia