Hepatocyte growth factor receptor signaling (WP94)

Rattus norvegicus

Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.


Daniela Digles , Lauren J. Dupuis , Eric Weitz , and Denise Slenter


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Rattus norvegicus



Pathway Ontology

Rho/Rac/Cdc42 mediated signaling pathway scatter factor/hepatocyte growth factor signaling pathway

Cell Type Ontology



Label Type Compact URI Comment
RAPGEF1 GeneProduct ncbigene:63881
Raf1 GeneProduct ncbigene:24703
Rap1b GeneProduct ncbigene:171337
Src GeneProduct ncbigene:83805
Ptk2 GeneProduct ncbigene:25614
Crk GeneProduct ncbigene:54245
Ptk2b GeneProduct ncbigene:50646
Pxn GeneProduct ncbigene:360820
Gab1 GeneProduct ncbigene:361388
Pten GeneProduct ncbigene:50557
Hgf GeneProduct ncbigene:24446
Map2k2 GeneProduct ncbigene:58960
Rasa1 GeneProduct ncbigene:25676
Ptk2b GeneProduct ncbigene:50646
Map4k1 GeneProduct ncbigene:292763
Met GeneProduct ncbigene:24553
Map2k1 GeneProduct ncbigene:170851
Src GeneProduct ncbigene:83805
Itga1 GeneProduct ncbigene:25118
Elk1 GeneProduct ncbigene:314436
Rap1a GeneProduct ncbigene:295347
Mapk1 GeneProduct ncbigene:116590
Pak1 GeneProduct ncbigene:29431
Mapk8 GeneProduct ncbigene:116554
PIK3CA GeneProduct ncbigene:170911
Crkl GeneProduct ncbigene:287942
Stat3 GeneProduct ncbigene:25125
Hras GeneProduct ncbigene:293621
Sos1 GeneProduct ncbigene:313845 Son of sevenless homolog 1 (Drosophila) (predicted)
Jun GeneProduct ncbigene:24516
Ptk2 GeneProduct ncbigene:25614
Grb2 GeneProduct ncbigene:81504
Itgb1 GeneProduct ncbigene:24511
Dock1 GeneProduct ncbigene:309081 Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
Ptpn11 GeneProduct ncbigene:25622
Pxn GeneProduct ncbigene:360820
Mapk3 GeneProduct ncbigene:50689
Fos GeneProduct ncbigene:314322


  1. An overview of the c-MET signaling pathway. Organ SL, Tsao MS. Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S7–19. PubMed Europe PMC Scholia