Hepatocyte growth factor receptor signaling (WP94)

Rattus norvegicus

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Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.

Authors

Daniela Digles , Lauren J. Dupuis , Eric Weitz , and Denise Slenter

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

Rho/Rac/Cdc42 mediated signaling pathway scatter factor/hepatocyte growth factor signaling pathway

Cell Type Ontology

hepatocyte

Participants

Label Type Compact URI Comment
RAPGEF1 GeneProduct ncbigene:63881
Raf1 GeneProduct ncbigene:24703
Rap1b GeneProduct ncbigene:171337
Src GeneProduct ncbigene:83805
Ptk2 GeneProduct ncbigene:25614
Crk GeneProduct ncbigene:54245
Ptk2b GeneProduct ncbigene:50646
Pxn GeneProduct ncbigene:360820
Gab1 GeneProduct ncbigene:361388
Pten GeneProduct ncbigene:50557
Hgf GeneProduct ncbigene:24446
Map2k2 GeneProduct ncbigene:58960
Rasa1 GeneProduct ncbigene:25676
Ptk2b GeneProduct ncbigene:50646
Map4k1 GeneProduct ncbigene:292763
Met GeneProduct ncbigene:24553
Map2k1 GeneProduct ncbigene:170851
Src GeneProduct ncbigene:83805
Itga1 GeneProduct ncbigene:25118
Elk1 GeneProduct ncbigene:314436
Rap1a GeneProduct ncbigene:295347
Mapk1 GeneProduct ncbigene:116590
Pak1 GeneProduct ncbigene:29431
Mapk8 GeneProduct ncbigene:116554
PIK3CA GeneProduct ncbigene:170911
Crkl GeneProduct ncbigene:287942
Stat3 GeneProduct ncbigene:25125
Hras GeneProduct ncbigene:293621
Sos1 GeneProduct ncbigene:313845 Son of sevenless homolog 1 (Drosophila) (predicted)
Jun GeneProduct ncbigene:24516
Ptk2 GeneProduct ncbigene:25614
Grb2 GeneProduct ncbigene:81504
Itgb1 GeneProduct ncbigene:24511
Dock1 GeneProduct ncbigene:309081 Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
Ptpn11 GeneProduct ncbigene:25622
Pxn GeneProduct ncbigene:360820
Mapk3 GeneProduct ncbigene:50689
Fos GeneProduct ncbigene:314322

References

  1. An overview of the c-MET signaling pathway. Organ SL, Tsao MS. Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S7–19. PubMed Europe PMC Scholia