Acetylcholine synthesis (WP476)

Danio rerio

Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.


Andrew Kwa , Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , Egon Willighagen , Friederike Ehrhart , Lauren J. Dupuis , and Eric Weitz


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Danio rerio



Pathway Ontology

acetylcholine metabolic pathway


Label Type Compact URI Comment
Acetyl-CoA Metabolite chebi:57288
Acetate Metabolite chebi:30089
Choline Metabolite chebi:15354
Acetylcholine Metabolite chebi:15355
Choline Metabolite chebi:15354
Glycerophosphocholine Metabolite chebi:36313
Posphatidylcholines Metabolite chebi:49183
Posphatidylethanolamines Metabolite chebi:16038
Cytidine diphosphate choline Metabolite chebi:16436
Phosphorylcholine Metabolite chebi:18132
chat GeneProduct ncbigene:100170938
chka GeneProduct ensembl:ENSDARG00000041078
ache GeneProduct ncbigene:114549
pemt GeneProduct ncbigene:393127
pcyt1aa GeneProduct ncbigene:550327
pdha1a GeneProduct ncbigene:406702


  1. Choline and cholinergic neurons. Blusztajn JK, Wurtman RJ. Science. 1983 Aug 12;221(4611):614–20. PubMed Europe PMC Scholia