Burn wound healing (WP5057)

Rattus norvegicus

This pathway is part of a systematic review on currently known molecular players in burn wound healing in mammalians.


Maximilian Saller , Egon Willighagen , Eric Weitz , and Lars Willighagen


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Rattus norvegicus



Cell Type Ontology

endothelial cell keratinocyte myofibroblast cell fibroblast

Pathway Ontology

cell-extracellular matrix signaling pathway immune response pathway


Label Type Compact URI Comment
CHP1 GeneProduct ensembl:ENSRNOG00000004742
ANKRD1 GeneProduct ensembl:ENSRNOG00000018598
PTGIS GeneProduct ensembl:ENSRNOG00000008245
ADORA2B GeneProduct ensembl:ENSRNOG00000002922
TNFRSF11B GeneProduct ensembl:ENSRNOG00000008336
MMP9 GeneProduct ensembl:ENSRNOG00000017539
IL1RL1 GeneProduct ensembl:ENSRNOG00000014835
ARFGAP1 GeneProduct ensembl:ENSRNOG00000043150
SAFB GeneProduct ensembl:ENSRNOG00000050543
SYK GeneProduct ensembl:ENSRNOG00000012160
SYP GeneProduct ensembl:ENSRNOG00000059720
TP53 GeneProduct ensembl:ENSRNOG00000010756
c5ar1 GeneProduct ensembl:ENSRNOG00000047800
GPR176 GeneProduct ensembl:ENSRNOG00000005971
ACAT1 GeneProduct ensembl:ENSRNOG00000007862
cdc25b GeneProduct ensembl:ENSRNOG00000021248
IL1B GeneProduct ensembl:ENSRNOG00000004649
Vegfa Protein uniprot:P16612
Pecam1 Protein uniprot:Q3SWT0 CD31
Type your comment here
Casp3 Protein uniprot:P55213
Col1a1 Protein uniprot:P02454
Col4a1 Protein uniprot:F1MA59
Krt6a Protein uniprot:Q4FZU2 Type your comment here
Cd44 Protein uniprot:P26051
CNN2 Protein uniprot:Q9R1E9
Bax Protein uniprot:Q63690
Dll4 Protein uniprot:D3ZHH1
Cox2 Protein uniprot:S5RZM8
Mmp9 Protein uniprot:P50282
Acta1 Protein uniprot:P68136
Epo Protein uniprot:P29676
Glb1 Protein uniprot:D3ZUM4
Nfkb1 Protein uniprot:Q63369
Pdgfa Protein uniprot:P28576
Vim Protein uniprot:P31000
Jun Protein uniprot:P17325 Type your comment here
Igf1 Protein uniprot:P08025
Il10 Protein uniprot:P29456
Col1a2 Protein uniprot:P02466
Mpo Protein uniprot:P11247 Type your comment here
Tnf Protein uniprot:P06804
Bcl2 Protein uniprot:P10417
Hgf Protein uniprot:Q08048
Il1b Protein uniprot:P10749
Cxcl12 Protein uniprot:P40224
Cxcr4 Protein uniprot:P70658 Type your comment here
Vim Protein uniprot:P20152 Type your comment here
Fgf2 Protein uniprot:P15655


  1. Effect of multiple gene transfers of insulinlike growth factor I complementary DNA gene constructs in rats after thermal injury. Jeschke MG, Barrow RE, Hawkins HK, Chrysopoulo MT, Perez-Polo JR, Herndon DN. Arch Surg. 1999 Oct;134(10):1137–41. PubMed Europe PMC Scholia
  2. Spatial and temporal expression of basic fibroblast growth factor protein during wound healing of rat skin. Kibe Y, Takenaka H, Kishimoto S. Br J Dermatol. 2000 Oct;143(4):720–7. PubMed Europe PMC Scholia
  3. Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound. Spies M, Nesic O, Barrow RE, Perez-Polo JR, Herndon DN. Gene Ther. 2001 Sep;8(18):1409–15. PubMed Europe PMC Scholia
  4. Gene expression analysis in burn wounds of rats. Spies M, Dasu MRK, Svrakic N, Nesic O, Barrow RE, Perez-Polo JR, et al. Am J Physiol Regul Integr Comp Physiol. 2002 Oct;283(4):R918-30. PubMed Europe PMC Scholia
  5. IGF-I gene transfer effects on inflammatory elements present after thermal trauma. Dasu MRK, Herndon DN, Nesic O, Perez-Polo JR. Am J Physiol Regul Integr Comp Physiol. 2003 Oct;285(4):R741-6. PubMed Europe PMC Scholia
  6. Mechanisms of postburn intestinal barrier dysfunction in the rat: roles of epithelial cell renewal, E-cadherin, and neutrophil extravasation. Al-Ghoul WM, Khan M, Fazal N, Sayeed MM. Crit Care Med. 2004 Aug;32(8):1730–9. PubMed Europe PMC Scholia
  7. The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma. Jeschke MG, Bolder U, Finnerty CC, Przkora R, Müller U, Maihöfer R, et al. Surgery. 2005 Sep;138(3):482–9. PubMed Europe PMC Scholia
  8. Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns. Avniel S, Arik Z, Maly A, Sagie A, Basst HB, Yahana MD, et al. J Invest Dermatol. 2006 Feb;126(2):468–76. PubMed Europe PMC Scholia
  9. Expression of endogenous transforming growth factor-beta and its type I and type II receptors in rat burn wounds. Wei D, Ge S, Chen Y, Dai F, Su B. Wound Repair Regen. 1997;5(3):229–34. PubMed Europe PMC Scholia
  10. Delayed wound healing in aged skin rat models after thermal injury is associated with an increased MMP-9, K6 and CD44 expression. Simonetti O, Lucarini G, Cirioni O, Zizzi A, Orlando F, Provinciali M, et al. Burns. 2013 Jun;39(4):776–87. PubMed Europe PMC Scholia
  11. Downregulation of let-7b promotes COL1A1 and COL1A2 expression in dermis and skin fibroblasts during heat wound repair. Liu J, Luo C, Yin Z, Li P, Wang S, Chen J, et al. Mol Med Rep. 2016 Mar;13(3):2683–8. PubMed Europe PMC Scholia
  12. Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degree burns. Castleberry SA, Golberg A, Sharkh MA, Khan S, Almquist BD, Austen WG Jr, et al. Biomaterials. 2016 Jul;95:22–34. PubMed Europe PMC Scholia
  13. The Notch Signaling System Is Involved in the Regulation of Reparative Angiogenesis in the Zone of Stasis. Abbas OL, Özatik O, Terzi YK, Özatik FY, Nar R, Turna G. J Burn Care Res. 2017;38(6):e923–33. PubMed Europe PMC Scholia
  14. Efficacy of erythropoietin-pretreated mesenchymal stem cells in murine burn wound healing: possible in vivo transdifferentiation into keratinocytes. Imam RA, Rizk AAE. Folia Morphol (Warsz). 2019;78(4):798–808. PubMed Europe PMC Scholia