Matrix metalloproteinases (WP1176)

Canis familiaris

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: [[wikipedia:Matrix_metalloproteinase|Wikipedia]]


Thomas Kelder , Daniela Digles , and Eric Weitz


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Canis familiaris



Pathway Ontology

cell-extracellular matrix signaling pathway


Label Type Compact URI Comment
MMP2 GeneProduct ncbigene:403733
MMP9 GeneProduct ncbigene:403885
MMP7 GeneProduct ncbigene:489432
MMP12 GeneProduct ncbigene:611789
MMP20 GeneProduct ncbigene:611829
MMP3 GeneProduct ncbigene:403445
MMP11 GeneProduct ncbigene:486408
MMP19 GeneProduct ncbigene:606853
MMP14 GeneProduct ncbigene:403823
MMP15 GeneProduct ncbigene:487257
MMP16 GeneProduct ncbigene:487036
MMP17 GeneProduct ncbigene:609890
MMP24 GeneProduct ncbigene:485849
TIMP2 GeneProduct ncbigene:403633
TIMP3 GeneProduct ncbigene:481289
TNF GeneProduct ncbigene:403922
MMP26 GeneProduct ncbigene:610101
MMP28 GeneProduct ncbigene:491136
MMP25 GeneProduct ncbigene:490046
MMP27 GeneProduct ncbigene:489430
TCF20 GeneProduct ncbigene:481224
MMP21 GeneProduct ncbigene:611418
MMP1 GeneProduct ncbigene:489428
MMP8 GeneProduct ncbigene:489429
MMP13 GeneProduct ncbigene:403763
TIMP1 GeneProduct ncbigene:403816
MMP23B GeneProduct ncbigene:607187


  1. Matrix metalloproteinases: effectors of development and normal physiology. Vu TH, Werb Z. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia