Exercise-induced circadian regulation (WP544)

Mus musculus

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Time- and exercise-dependent gene regulation in human skeletal muscle, http://genomebiology.com/2003/4/10/R61 Mouse genes regulated in the diurnal (inferred from human) and compared with mouse genes that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianly regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianly regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianly regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.

Authors

Alexander C. Zambon , Chris Evelo , Kristina Hanspers , Martina Summer-Kutmon , Alex Pico , Susan Coort , and Eric Weitz

Activity

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

regulatory pathway

Cell Type Ontology

skeletal muscle fiber

Participants

Label Type Compact URI Comment
Ucp3 GeneProduct ncbigene:22229 93392 at
Vapa GeneProduct ncbigene:30960 94889 at
Arntl GeneProduct ncbigene:11865
Sumo3 GeneProduct ncbigene:20610 95424 at
Per2 GeneProduct ncbigene:18627
Cebpb GeneProduct ncbigene:12608 92925 at
Zfr GeneProduct ncbigene:22763 104050 at
Pigf GeneProduct ncbigene:18701 104725 at
Gstm3 GeneProduct ncbigene:14864 97681 f at
Sf3a3 GeneProduct ncbigene:75062 96029 at
Hist1h2bn GeneProduct ncbigene:319187 93833 s at
Cry1 GeneProduct ncbigene:12952
Tob1 GeneProduct ncbigene:22057 99532 at
Oazin GeneProduct ncbigene:54375 101002 at
Pura GeneProduct ncbigene:19290 103501 at
D5Ertd593e GeneProduct ncbigene:52331 104116 at
Herpud1 GeneProduct ncbigene:64209 95057 at
Ppp2cb GeneProduct ncbigene:19053 101101 at
Cldn5 GeneProduct ncbigene:12741 104516 at
Nr1d2 GeneProduct ncbigene:353187 99076 at
G0s2 GeneProduct ncbigene:14373 97531 at
Eif4g2 GeneProduct ncbigene:13690 100535 at
Cry2 GeneProduct ncbigene:12953
Clock GeneProduct ncbigene:12753
Myf6 GeneProduct ncbigene:17878 102265 at
Nckap1 GeneProduct ncbigene:50884 95508 at
Dnaja1 GeneProduct ncbigene:15502 97261 at
Nr1d1 GeneProduct ncbigene:217166
Cbx3 GeneProduct ncbigene:12417 100405 at
Ncoa4 GeneProduct ncbigene:27057 97843 at
Ppp1r3c GeneProduct ncbigene:53412 93933 at
Etv6 GeneProduct ncbigene:14011 93866 s at
Ugp2 GeneProduct ncbigene:216558 94481 at
Per1 GeneProduct ncbigene:18626
D14Ertd171e GeneProduct ncbigene:238988 93829 at
Tubb4 GeneProduct ncbigene:22153 94835 f at
Dazap2 GeneProduct ncbigene:23994 94454 at
Gstp2 GeneProduct ncbigene:14869 99583 at
Qk GeneProduct ncbigene:19317 95096 at
Hspa8 GeneProduct ncbigene:15481 96564 at
Map3k7ip2 GeneProduct ncbigene:68652 160309 at
Psma4 GeneProduct ncbigene:26441 97459 at
Gfra1 GeneProduct ncbigene:14585 93872 at
H2-DMa GeneProduct ncbigene:14998 162346 f at
Bteb1 GeneProduct ncbigene:16601 93527 at
Btg1 GeneProduct ncbigene:12226 93104 at
Rbpms GeneProduct ncbigene:19663 103888 at
Sumo1 GeneProduct ncbigene:22218 101091 at
Idi1 GeneProduct ncbigene:319554 96269 at

References

  1. Time- and exercise-dependent gene regulation in human skeletal muscle. Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, et al. Genome Biol. 2003;4(10):R61. PubMed Europe PMC Scholia