Robo4 and VEGF signaling pathways crosstalk (WP3943)

Homo sapiens

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This pathway is based on Figure 2 of "Robo4" (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637482/). The gene Robo4 plays a role in regulating vascular stability in mice. Robo4 inhibits the gene Notch1, which regulates tip cell formation, in order to create more tip cells. Robo4 also inhibits cell migration, decreasing vessel complexity. The combination of Slit2 and Robo4 inhibits the activation of Src by VEGF-165 and VEGFR2. This inhibition reduces vascular leakage of Evans Blue from retinal blood vessels. More experimentation is necessary to determine whether Robo4 will inhibit other members of the Src family. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3943 CPTAC Assay Portal]

Authors

Kristina Hanspers and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

regulatory pathway Notch signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ROBO4 GeneProduct ensembl:ENSG00000154133 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032125
SLIT2 GeneProduct ensembl:ENSG00000145147 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031558
KDR GeneProduct ensembl:ENSG00000128052 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000062960
RAC1 GeneProduct ensembl:ENSG00000136238 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847
VEGFA GeneProduct ensembl:ENSG00000112715 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023951
SRC GeneProduct ensembl:ENSG00000197122 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027646

References

  1. Robo4: a guidance receptor that regulates angiogenesis. Weitzman M, Bayley EB, Naik UP. Cell Adh Migr. 2008;2(4):220–2. PubMed Europe PMC Scholia