Drug induction of bile acid pathway (WP2289)

Homo sapiens

Several drug (e.g. chlozapine) and their inhibitory effects on targets of the bile acid production pathway.


Rianne Fijten , Egon Willighagen , Susan Coort , Martina Summer-Kutmon , Roelod , and Eric Weitz


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Homo sapiens



Pathway Ontology

drug pathway bile acid signaling pathway


Label Type Compact Identifier Comment
Chlorpromazine Metabolite pubchem.compound:2726
Bile Acids Metabolite chebi:3098
Ezetimibe Metabolite pubchem.compound:150311
Troglitazone Metabolite pubchem.compound:5591
Cholesterol Metabolite hmdb:HMDB0000067
Tetrahydrocortisone Metabolite hmdb:HMDB0000903
Cyclosporin Metabolite pubchem.compound:5284373
Glycocholic acid Metabolite hmdb:HMDB0000138
Clozapine Metabolite pubchem.compound:135398737
Taurocholic acid Metabolite hmdb:HMDB0000036
Bilirubin Metabolite hmdb:HMDB0000054
Isoursodeoxycholic acid Metabolite hmdb:HMDB0000686
Deoxycholic acid Metabolite hmdb:HMDB0000626
Methylprednisolone Metabolite pubchem.compound:6741
Cimetidine Metabolite pubchem.compound:2756
Phospholipids Metabolite chebi:16247
Digoxin Metabolite hmdb:HMDB0001917
Clarithromyci Metabolite pubchem.compound:84029
Erythromycin Metabolite pubchem.compound:12560
Silybin Metabolite pubchem.compound:31553
Glyburide Metabolite pubchem.compound:3488
Tacrolimus Metabolite pubchem.compound:445643
Trabectedin Metabolite pubchem.compound:108150
Phomin Metabolite pubchem.compound:5311281
Colchicine Metabolite pubchem.compound:6167
Ranitidine Metabolite hmdb:HMDB0001930
Oxiglutatione Metabolite pubchem.compound:65359
SLCO1B1 GeneProduct ncbigene:10599
SULT2A1 GeneProduct ncbigene:6822
CYP3A4 GeneProduct ncbigene:1576
SLC10A1 GeneProduct ncbigene:6554
CYP7A1 GeneProduct ncbigene:1581
BAAT GeneProduct ncbigene:570
ABCB1 GeneProduct ncbigene:5243
NR1H4 GeneProduct ncbigene:9971
OSTalpha GeneProduct ncbigene:200931
VDR GeneProduct ncbigene:7421
NR1I3 GeneProduct ncbigene:9970
NR1I2 GeneProduct ncbigene:8856
OSTBETA GeneProduct ncbigene:123264
ABCC4 GeneProduct ncbigene:10257
ABCB11 GeneProduct ncbigene:8647
ABCC3 GeneProduct ncbigene:8714
ABCC2 GeneProduct ncbigene:1244