Synaptic vesicle pathway (WP2267)
Pathway depicting synaptic transmission of neurotransmitters from the presynaptic nerve terminal to the synaptic cleft upon depolarization. Synaptotagmin mediated transport along the nerve cell cytoskeleton indicates the initial step of this process. Originally created by Joanna S. Fong and Nathan Salomonis in the Bruce Conklin laboratory 5/12/2000 for use in GenMAPP. Genes associated with neurotransmitter reuptake from the synaptic left were obtained from the Gene Ontology term GO:0001504. For additional information see: http://en.wikipedia.org/wiki/Synaptic_vesicle. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2267 CPTAC Assay Portal].
AuthorsNathan Salomonis , Egon Willighagen , Friederike Ehrhart , Kristina Hanspers , and Eric Weitz
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- Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse (2019).
- A Systems-Level Perspective of Sudden Infant Death Syndrome (2014).
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