Nuclear receptors (WP170)

Homo sapiens

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia ([[wikipedia:Nuclear_receptor]]) Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Ellen Tuninsky , Thomas Kelder , Kristina Hanspers , Michiel Adriaens , Alex Pico , Daniela Digles , Egon Willighagen , and Eric Weitz


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Homo sapiens



Pathway Ontology

transcription factor mediated signaling pathway


Label Type Compact URI Comment
retinoicacid Metabolite chebi:26536
Oxysterols Metabolite chebi:53030
d3 vitamins Metabolite chebi:73558
estrogen Metabolite chebi:50114
progesterone Metabolite chebi:17026
THRA GeneProduct ncbigene:7067
THRB GeneProduct ncbigene:7068
THRB GeneProduct ncbigene:7068
RARA GeneProduct ncbigene:5914
RARB GeneProduct ncbigene:5915
RARG GeneProduct ncbigene:5916
RARG GeneProduct ncbigene:5916
PPARA GeneProduct ncbigene:5465
PPARD GeneProduct ncbigene:5467
PPARG GeneProduct ncbigene:5468
PPARG GeneProduct ncbigene:5468
NR1D2 GeneProduct ncbigene:9975
NR0B1 GeneProduct ncbigene:190
ROR1 GeneProduct ncbigene:4919
RORA GeneProduct ncbigene:6095
RORC GeneProduct ncbigene:6097
NR1H2 GeneProduct ncbigene:7376
NR1H3 GeneProduct ncbigene:10062
VDR GeneProduct ncbigene:7421
HNF4A GeneProduct ncbigene:3172
RXRA GeneProduct ncbigene:6256
RXRB GeneProduct ncbigene:6257
RXRG GeneProduct ncbigene:6258
NR2C2 GeneProduct ncbigene:7182
NR2F1 GeneProduct ncbigene:7025
NR2F2 GeneProduct ncbigene:7026
NR2F6 GeneProduct ncbigene:2063
NR2E1 GeneProduct ncbigene:7101
ESR1 GeneProduct ncbigene:2099
ESR2 GeneProduct ncbigene:2100
ESRRA GeneProduct ncbigene:2101
ESRRB GeneProduct ncbigene:2103
NR3C1 GeneProduct ncbigene:2908
PGR GeneProduct ncbigene:5241
AR GeneProduct ncbigene:367
NR4A1 GeneProduct ncbigene:3164
NR4A2 GeneProduct ncbigene:4929
NR5A1 GeneProduct ncbigene:2516
NR5A2 GeneProduct ncbigene:2494
NR1I2 GeneProduct ncbigene:8856
NR1I3 GeneProduct ncbigene:9970


  1. Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease. Nagy L, Schüle R, Gronemeyer H. EMBO Rep. 2006 Jun;7(6):579–84. PubMed Europe PMC Scholia