Opioid receptor pathways (WP5093)

Homo sapiens

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Opioid signaling from four receptor subtypes.

Authors

Dr. T. S. Keshava Prasad , Eric Weitz , Egon Willighagen , and Kristina Hanspers

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to the brain and nervous system

Participants
Query Drugst.One

Label Type Compact URI Comment
Diacylglycerol Metabolite chebi:88364
PIK3CG GeneProduct ncbigene:5294
PLD2 GeneProduct ncbiprotein:NP_002654.3 [Pubmed:16539674] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively and induces activation of PLD2 in an ARF-GTP dependent manner in HEK293 cells
[Pubmed:19519662] have shown that DAMGO stimulates OPRM1 and induces activation of PLD2 in HEK293 cells.
[Pubmed: 19666113] have shown that DAMGO stimulates OPRM1 and induces activation of PLD2 in an ARF6 dependent manner in HEK293 cells and neuronal cells of E17 Sprague-Dawley rats.
NOS2 GeneProduct ncbigene:4843 [Pubmed: 27226238] have shown that U50,488H stimulates OPRK1 and induces downregulation of NOS2 in aorta of hyperlipidemic rats.
[Pubmed: 27226238] have shown that U50,488H stimulates OPRK1 and induces inhibition of NOS2 activity in aorta of hyperlipidemic rats.
PLD2 GeneProduct ncbiprotein:NP_002654.3 Pubmed:16539674] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively and induces activation of PLD2 in an ARF-GTP dependent manner in HEK293 cells
AKT1 GeneProduct ncbiprotein:NP_005154.2 [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phophorylation of AKT1 at Ser473 in a Gi/G0 coupled-PI3K dependent manner in HEK293 cells.
[Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of AKT1 at Ser473 in HEK293 cells in a PI3K dependent manner
[Pubmed:15056283] have shown that DAMGO stimulates MOR and induces PI3Kgamma mediated AKT1 phosphorylation at S473 in SHSY5Y and COS7 cells.
[Pubmed:19765550] have shown morphine stimulates MOR and induces phosphorylation of AKT1 at Ser 473 in CEMx174 cells.
OPRM1 GeneProduct ncbigene:4988
GSK3B GeneProduct ncbiprotein:NP_002084.2 [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of GSK3B at Ser9 in HEK293 cells.
RPS6KB1 GeneProduct ncbiprotein:NP_003152.1 Pubmed 9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of RPS6KB1 at Thr389, Thr421/Ser424 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells.
[Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces activation of RPS6KB1 in HEK293 cells.
[Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of RPS6KB1 at Thr 389 in HEK293 cells in a PI3K-AKT1-MTOR dependent manner.
EIF4EBP1 GeneProduct ncbiprotein:NP_004086.1 [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of EIF4EBP1 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells.
EIF4EBP2 GeneProduct ncbiprotein:NP_004087.1 [Pubmed:9722592] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of EIF4EBP2 in a PI3K and FRAP/mTOR dependent manner in HEK293 cells.
RPS6KB1 GeneProduct ncbiprotein:NP_003152.1 [Pubmed: 9224649] have shown that DADLE stimulates OPRD1 and induces activation of RPS6KB1 in a Gi/G0, PI3K and FRAP/RAFT dependent manner in D2 cells.
PRKCZ GeneProduct ncbiprotein:NP_005154.2 [Pubmed:21250979] have shown that SNC80 and DPDPE stimulates DOR and induces phosphorylatio of PRKCZ at T410 in a PI3K dependent manner in CHO cells.
[Pubmed: 19682542] have shown that Loperamide stimulates MOR and induces phosphorylation of PRKCZ at Thr 410 in myoblasts C2C12 cells.
PLCB3 GeneProduct ncbiprotein:NP_000923.1 [Pubmed:9572309] have shown that DAMGO stimulates MOR and induces activation of PLCB3 in a Gbetagamma mediated PLCB3 activation in CHO cells.
[Pubmed:19020012] have shown that morphine/DAMGO stimulates MOR and induces Gbetagamma mediated PLCB3 activation in CHO cells.
[Pubmed:9572309] have shown that DPDPE, U-50,488H and DAMGO stimulate DOR, KOR, MOR respectively, and induce activation of PLCB3 in a Galpha16 dependent manner in COS-7 cells.
EEA1 GeneProduct ncbiprotein:NP_003557.3 [Pubmed:20354103] have shown that DAMGO stimulateS OPRM1 and incudes activation of EEA1 in SH-SY5Y cells.
PDGFRB GeneProduct ncbiprotein:NP_002600.1 [Pubmed:16918381] have shown that morphine stimulates MOR and induces phosphorylation of PDGFRB at Y716 in mouse retinal endothelial cells.
KDR GeneProduct ncbiprotein:NP_002244.1 [Pubmed:16918381] have shown that morphine stimulates MOR and induces phosphorylation of KDR at Y1212 in mouse retinal endothelial cells.
CDK5 GeneProduct ncbiprotein:NP_004926.1 [Pubmed:16879821] have shown that DAMGO stimulates OPRM1 and induces activation of CDK5 in SH-SY5Y cells.
STAT3 GeneProduct ncbiprotein:NP_003141.2 [Pubmed: 16918381] have shown that morphine stimulates MOR and induces MOR/KDR mediated STAT3 phosphorylation at Y705 in mouse retinal endothelial cells
[Pubmed:21801866] have shown that DALDA stimulates MOR and induces STAT3 phosphorylation at Tyr 705 in mouse colonocytes.
[Pubmed:16918381] have shown that morphine stimulates MOR and induces translocation of phosphorylated STAT3 from cytosol to nucleus under the influence of MOR/KDR in mouse retinal endothelial cells.
[Pubmed:16879821] have shown that DAMGO stimulates MOR and induces STAT3 phosphorylation at Ser 727 in SH-SY5Y cells.
PDK1 GeneProduct ncbiprotein:NP_001265478.1 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PDK1 at Y373/Y376 in M13 cells
PRKCZ GeneProduct ncbiprotein:NP_002735.3 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PDK1 at Y373/Y376 in M13 cells
PRKCZ GeneProduct ncbiprotein:NP_002735.3 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PRKCZ at Thr 410 in a PDK1 mediated manner in CHO and M13 cells
[Pubmed:21454526] has shown that DAMGO stimulates MOR and induces activation of PRKCZ in M13 cells.
PRKCZ GeneProduct ncbiprotein:NP_002735.3 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of PDK1 at Y373/Y376 in M13 cells
CCR5 GeneProduct ncbiprotein:NP_000570.1 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces association of CCR5 and activated PRKCZ in M13 cells
CCR5 GeneProduct ncbiprotein:NP_000570.1 [Pubmed:21454526] have shown that DAMGO stimulates MOR and induces phosphorylation of CCR5 at S349 in a PRKCZ dependent manner in M13 cells
IGF1R GeneProduct ncbiprotein:NP_000866.1 [Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of IGF1R at Tyr1135/ Tyr1136 in chinese hamster cells.
GSK3B GeneProduct ncbiprotein:NP_002084.2 [Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of GSK3B at Ser9 in rat nuclear accumbens.
AKT1 GeneProduct ncbiprotein:NP_005154.2 [Pubmed:21250979] have shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of AKT1 at T308 in a PI3Kalpha dependent manner in CHO cells.
[Pubmed: 21515255] have shown that NDMC stimulates DOR and induces phosphorylation of AKT1 at T308 in rat nuclear accumbens.
[Pubmed:16249373] have shown that DADLE stimulates DOR and induces phophorylation of AKT1 at Ser473 in a PI3K independent manner in murine splenocytes.
STAT3 GeneProduct ncbiprotein:NP_003141.2 [Pubmed: 22033345] have shown that SNC80 stimulates DOR and induces phosphorylation of STAT3 at S727 in rat bone marrow derived mesenchymal stem cells.
CREB1 GeneProduct ncbiprotein:NP_604391.1 [Pubmed: 23682813] have shown that morphine stimulates MOR and induces phosphorylation of CREB1 at S133 in mice striatum
GRIN1 GeneProduct ncbiprotein:NP_001172020.1 [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of GRIN1 at S890 in male albino CD1 mice.
GRIN2A GeneProduct ncbiprotein:NP_000824.1 [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of GRIN2A at Y1325 in male albino CD1 mice.
CAMK2A GeneProduct ncbiprotein:NP_057065.2 [Pubmed:25445489] have shown that morphine stimulates MOR and induces phosphorylation of CAMK2A at T286 in male albino CD1 mice.
RAC1 GeneProduct ncbigene:5879 [Pubmed: 27634008] have shown that U50488 stimulate KOR and induces the downregulation of RAC1 in mouse hippocampus
BDNF GeneProduct ncbigene:627 [Pubmed: 27634008] have shown that U50488 stimulates KOR and induces the downregulation of BDNF in mouse Hippocampus, prefrontal cortex and primart cortical neurons
AKT1 GeneProduct ncbiprotein:NP_005154.2 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces the phosphorylation of AKT1 at S473 in a G alpha i/0 mediated manner in CHO-KOR cells and mice striatal neurons
STAT5B GeneProduct ncbiprotein:NP_036580.2 [Pubmed:23906478] have shown that DSLET stimulates DOR and induces phosphorylation of STAT5B at Y699 in a G alpha i/0 dependent manner in Neuro 2A cells
STAT3 GeneProduct ncbiprotein:NP_003141.2 [Pubmed:23996400] have shown that BRL52537 stimulates KOR and induces phosphorylation of STAT3 at Y705 in ischemia reperfused rat hippocampal CA1 region.
CREB1 GeneProduct ncbiprotein:NP_604391.1 [Pubmed:28097228] have shown that U-50,488H stimulates KOR and induces phosphorylation of CREB1 at S133 in porcine articular chondrocytes.
CASP1 GeneProduct ncbiprotein:NP_150634.1 [Pubmed:26162710] have shown that morphine stimulates MOR and induces cleavage induced activation of CASP1 in a PI3K/AKT mediated manner in rat spinal cord tissue.
CASP1 GeneProduct ncbiprotein:NP_150634.1 [Pubmed:26162710] have shown that morphine stimulates MOR and induces cleavage induced activation of CASP1 in a PI3K/AKT mediated manner in rat spinal cord tissue.
IL1B GeneProduct ncbiprotein:3553 [Pubmed:26162710] have shown that morphine stimulates MOR and induces upregulation of IL1B in a PI3K/AKT/CASP1 dependent manner in rat primary spinal neurons.
IL1B GeneProduct ncbiprotein:3553 [Pubmed:26162710] have shown that morphine stimulates MOR and induces upregulation of IL1B in a PI3K/AKT/CASP1 dependent manner in rat primary spinal neurons.
IL1B GeneProduct ncbiprotein:3553 [Pubmed:26162710] have shown that morphine stimulates MOR and induces upregulation of IL1B in a PI3K/AKT/CASP1 dependent manner in rat primary spinal neurons.
IL1B GeneProduct ncbiprotein:3553 [Pubmed:26162710] have shown that morphine stimulates MOR and induces upregulation of IL1B in a PI3K/AKT/CASP1 dependent manner in rat primary spinal neurons.
NOS1 GeneProduct ncbiprotein:NP_001191147.1 [Pubmed:21348811] have shown that morphine stimulates MOR and induces phosphorylation of NOS1 at Ser 1417 activated by AKt1 cascade in mouse PAG synaptosomes.
RGS17 GeneProduct ncbiprotein:NP_036551.3 [Pubmed:21348811] have shown that morphine stimulates MOR induces association of activated NOS1 and RGS17 in mouse PAG synaptosomes.
NOS1 GeneProduct ncbiprotein:NP_001191147.1 [Pubmed:21348811] have shown that morphine stimulates MOR induces association of OPRM1 and NOS1 in mouse PAG synaptosomes.
OPRM1 GeneProduct ncbiprotein:NP_001138751.1 [Pubmed:21348811] have shown that morphine stimulates MOR induces association of activated NOS1 and RGS17 in mouse PAG synaptosomes.
CACNA1B GeneProduct ncbigene:774 [Pubmed:16311589] have shown that nociceptin stimulates ORL1 and induces translocation of OPRL1-CACNA1B complex from cell membrane to cytosol in CHO cells and rat DRG neurons.
PRKCG GeneProduct ncbiprotein:NP_001303258.1 [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of PRKCG at S729 in mouse spinal glial cells.
MAPK8 GeneProduct ncbiprotein:NP_001265476.1 [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of MAPK8 at T183 in mouse spinal glial cells.
MAPK9 GeneProduct ncbiprotein:NP_620709.1 [Pubmed: 25806604] have shown that moprhine stimulates MOR and induces phosphorylation of MAPK9 at Y185 in mosue spinal glial cells
JUN GeneProduct ncbiprotein:NP_002219.1 [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of JUN at S73 in mouse spinal glial cells.
MAPK9 GeneProduct ncbiprotein:NP_620709.1 [Pubmed:15056283] have shown that DAMGO stimulates MOR and U-50,488H stimulates KOR and induces phosphorylation of MAPK9 at Tyr185 in SHSY5Y cells and THP1 cells, respectively.
MAPK9 GeneProduct ncbiprotein:NP_620709.1 [Pubmed: 25806604] have shown that moprhine stimulates MOR and induces phosphorylation of MAPK9 at Y185 in mosue spinal glial cells
NFE2L2 GeneProduct ncbiprotein:NP_006155.2 [Pubmed:30595095] have shown that dynorphin A stimulates OPRK1 and induces translocation of NFE2L2 from cytosol to nucleus in rat hippocampal neurons.
EGFR GeneProduct ncbiprotein:NP_005219.2 [Pubmed:17545478] have shown that DADLE stimulates DOR and induces phosphorylation of EGFR at Tyr 1173 in isolated rabbit heart
JUN GeneProduct ncbiprotein:NP_002219.1 [Pubmed: 25806604] have shown that morphine stimulates MOR and induces phosphorylation of JUN at S73 in mouse spinal glial cells.
JUN GeneProduct ncbiprotein:NP_002219.1 [Pubmed:16249373] have shown that DADLE stimulates DOR and induces phosphorylation of JUN at Ser63 in an AKT dependent manner in mouse splenocytes.
AKT GeneProduct refseq:NP_005154.2 [Pubmed:24654606] have shown that morphine stimulates MOR and induces phosphorylation of AKT1 at Ser473 and Thr308 in µ-SK-N-LO cells and mouse sensory DRG neurons.
RELA Protein ncbigene:5970 [Pubmed:23402995] have shown that U50,488H stimulates OPRK1 and induces downregulation of RELA in Male Sprague Dawley rat myocardial infarction and reperfusion heart model.
MAP2K1 Protein ncbiprotein:NP_002746.1 [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAP2K1 in a RAF1 dependent manner in HEK293 cells
KRAS Protein ncbiprotein:NP_004976.2 [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces activation of KRAS in HEK293 cells
RAF1 Protein ncbiprotein:NP_001341618.1 [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces activation of RAF1 in HEK293 cells.
[Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of RAF1 at Tyr340/341 in HEK293 cells
SRC Protein ncbiprotein:NP_005408.1 Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of SRC at Tyr416 in HEK293 cells.
AKT1 Protein ncbiprotein:NP_005154.2 [Pubmed:27226238] has shown that U50,488H stimulates OPRK1 and induces phosphorylation of AKT1 at Ser273 in human umbilical vein endothelial cell lines (HUVECs) and aorta of hyperlipidemic rat.
[Pubmed:30595095] have shown that dynorphin A stimulates KOR and induces phosphorylation of AKT1 at Ser 473 in a PI3K dependent manner in rat hippocampal neurons
NOS3 Protein ncbiprotein:NP_000594.2 [Pubmed:27226238] has shown that U50,488H stimulates OPRK1 and induces phosphorylation of NOS3 at Ser1177 in human umbilical vein endothelial cell lines (HUVECs) and aorta of hyperlipidemic rat.
[Pubmed: 27226238] have shown that U50,488H stimulates OPRK1 and induces activation of NOS3 in aorta of hyperlipidemic rats.
OPRD1 Protein ncbiprotein:NP_000902.3 [Pubmed:16539674] have shown that DPDPE stimulates OPRD1 and induces transport of OPRD1 from plasma membrane to cytosol in HEK293 cells.
OPRD1 Protein ncbiprotein:NP_000902.3 [Pubmed:16539674] have shown that DPDPE stimulates OPRD1 and induces transport of OPRD1 from plasma membrane to cytosol in HEK293 cells.
[Pubmed: 10893226] have shown that deltorphinII stimultes OPRD1 and induces transport of OPRD1 from the plasma membrane to cytosol in HEK293 cells.
[Pubmed:10884553] have shown that DTLET stimulates OPRD1 and induces transport of OPRM1 from plasma membrane to cytosol in C6 cells
PRKCE Protein ncbiprotein:NP_005391.1 [Pubmed:24113748] have shown that morphine stimulates OPRM1 and induces activation of PRKCE in HEK293 cells
[Pubmed:20043990] have shown that morphine stimulates OPRM1 and induces activation of PRKCE in HEK293 cells.
[Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of PRKCE from cytosol to plasma membrane in SH-SY5Y cells.
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:22736766] have shown that 6'-GNTI/EKC/U50488 stimulates KOR and induces activation of OPRK1 in HEK293T cells
[Pubmed: 10334841] have shown that U69,593 stimulates OPRK1 and induces activation of OPRK1 in CHO-K1 cells
PPP3CA Protein ncbiprotein:NP_000935.1 [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells
FKBP1A Protein ncbiprotein:NP_000792.1 [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells
SLC6A3 Protein ncbiprotein:NP_001035.1 [Pubmed:25107591] have shown that SalA, U69,593 and U50,488 stimulates OPRK1 and induces activation of SLC6A3 in a Gi/Go and ERK1/2 dependent manner in EM4 cells
[Pubmed:25107591] have shown that SalA stimulates KOR and induces upregulation of SLC6A3 protein in human EM4 cells and rat striatal synaptosomes.
FOS Protein ncbiprotein:NP_005243.1 [Pubmed:23062312] have shown that U50,488 stimulates OPRK1 and induces activation of FOS in mice hypothalamic arcuate nucleus neurons.
ELK1 Protein ncbiprotein:NP_001107595.1 [Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1and induces phosphorylation of ELK1 at Ser383 in cord blood hematopoietic stem cells (CD34+ cells).
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:9721727] have shown that Nociceptin and DAMGO stimulates OPRL1 and OPRM1 respectively and induces activation of MAPK1 in CHO-ORL1, CHO-u and COS-7 cells in a Gi/G0, PI3K and SOS activity dependent manner.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:9721727] have shown that Nociceptin and DAMGO stimulates OPRL1 and OPRM1 respectively and induces activation of MAPK3 in CHO-ORL1, CHO-u and COS-7 cells in a Gi/G0, PI3K and SOS activity dependent manner.
OPRD1 Protein ncbiprotein:NP_000902.3 [Pubmed:24976397] have shown that DAMGO, deltorphinII and DPDPE stimulates OPRM1, OPRM1-OPRD1 heteromer and OPRD1 respectively and induces activation of GNAI3 in rat striatum and hippocampus.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:24113748] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAPK1 at Thr202 in a PRKCE dependent manner in HEK293 cells.
[Pubmed:15944153] have shown that DAMGO and U-69,593 stimulate MOR and KOR and induce MAPK1 phosphorylation in a PLC/CAM mediated and PI3K mediated manner, respectively in rat cortical astrocytes.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:24113748] have shown that morphine stimulates OPRM1 and induces phosphorylation of MAPK3 at Tyr204 in a PRKCE dependent manner in HEK293 cells
[Pubmed:15944153] have shown that DAMGO and U-69,593 stimulate MOR and KOR and induce MAPK1 phosphorylation in a PLC/CAM mediated and PI3K mediated manner, respectively in rat cortical astrocytes.
OPRL1 Protein ncbiprotein:NP_001305782.1 [Pubmed: 10334841] have shown that Nociceptin stimulates OPRL1 and induces activation of OPRL1 in CHO-K1 cells
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:10884553] have shown that morphine stimulates OPRM1 and OPRD1; DAMGO and DTLET stimulates OPRM1 and OPRD1 respectively and induces phosphorylation of MAPK1 in CHO and C6 cells
[Pubmed:10884553] have shown that DTLET and DAMGO stimulate OPRD1 and OPRM1 respectively and induces activation of MAPK1 in CHO cells.
[Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces phosphorylation of MAPK1 at Thr185/Y187 in cord blood hematopoietic stem cells (CD34+ cells)
Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces activation of MAPK1 in cord blood hematopoietic stem cells (CD34+ cells).
[Pubmed:10452557] have shown that morphine and endomorphine-1 stimulate OPRM1 and induces the activation MAPK1 in a PI3K, PTK and PKC dependent manner in CHO- K1 cells
MAPK3 Protein ncbiprotein:NP_002736.3 Pubmed:10884553] have shown that morphine stimulates OPRM1 and OPRD1; DTLET and DAMGO stimulates OPRD1 and OPRM1 respectively and induces phosphorylation of MAPK3 in CHO and C6 cells
[Pubmed:10884553] have shown that DTLET and DAMGO stimulate OPRD1 and OPRM1 respectively and induces activation of MAPK3 in CHO cells.
[Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces phosphorylation of MAPK3 at Thr202/Y204 in cord blood hematopoietic stem cells (CD34+ cells)
Pubmed: 12031654] have shown that morphine or enkaphalin stimulates OPRM1 and induces activation of MAPK3 in cord blood hematopoietic stem cells (CD34+ cells).
[Pubmed:10452557] have shown that morphine and endomorphine-1 stimulate OPRM1 and induces the activation MAPK1 in a PI3K, PTK and PKC dependent manner in CHO- K1 cells
OPRD1 Protein ncbiprotein:NP_000902.3 [Pubmed:24976397] have shown that DAMGO, deltorphinII and DPDPE stimulates OPRM1, OPRM1-OPRD1 heteromer and OPRD1 respectively and induces activation of GNAI3 in rat striatum and hippocampus.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:9224649] have shown that DADLE stimulates OPRD1 and induces activation of MAPK1 in a PI3K independent manner in rat D2 cells.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:9224649] have shown that DADLE stimulates OPRD1 and induces activation of MAPK3 in a PI3K independent manner in rat D2 cells.
TNF Protein ncbigene:7124 [Pubmed:23402995] have shown taht U50,488H stimulates OPRK1 and induces downregulation of TNF in Male Sprague Dawley rat myocardial infarction and reperfusion heart model.
[Pubmed:22806643] have shown that DAMGO stimulates OPRM1 and induces downregulation of TNF in ischemia and reperfusion heart model of mice.
MTOR Protein ncbiprotein:NP_004949.1 [Pubmed:26096047] have shown that morphine stimulates OPRM1 and induces phosphorylation of MTOR at Ser2448 in HEK293 cells ina PI3K-AKT1 dependent manner.
GPX1 Protein ncbiprotein:NP_000572.2 [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces increased activation of GPX1 in ischemia and reperfusion brain model of rats.
CASP3 Protein ncbiprotein:836 [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces downregulation of CASP3 in cerebral ischemia and reperfusion brain model of rat.
TLR4 Protein ncbigene:7099 [Pubmed:23402995] have shown that U50,488H stimulates OPRK1 and induces downregulation of TLR4 in Male Sprague Dawley rat's myocardial infarction and reperfusion heart model.
ADCY5 Protein ncbiprotein:NP_000792.1 [Pubmed:24061856] have shown that morphine stimulates MOR and induces association of OPRM1 and ADCY5 in HEK293 cells
ADCY6 Protein ncbiprotein:NP_000792.1 [Pubmed:24061856] have shown that morphine stimulates MOR and induces association of OPRM1 and ADCY6 in HEK293 cells
SRC Protein ncbiprotein:NP_005408.1 [Pubmed:21250979] have shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of SRC at Y416 in a Gi/G0 dependent manner in CHO cells.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:21250979] has shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of MAPK1 in CHO cells.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:21250979] has shown that SNC80 and DPDPE stimulates DOR and induces phosphorylation of MAPK3 in CHO cells.
MAPK8 Protein ncbiprotein:NP_001265476.1 [Pubmed:15056283] have shown that U-50,488H stimulates KOR and induces phosphorylation of MAPK8 at T183 in THP1 cells.
[Pubmed:26297384] have shown that salvinorin A stimulates KOR and induces phosphorylation of MAPK8 in rat peripheral sensory neurons.
[Pubmed:15056283] have shown that DAMGO stimulates MOR and U-50,488H stimulates KOR and induces activation of MAPK8 in SHSY5Y cells and THP1 cells, respectively.
MAPK8 Protein ncbiprotein:NP_001265476.1 [Pubmed:15056283] have shown that DAMGO stimulates MOR and U-50,488H stimulates KOR and induces activation of MAPK8 in SHSY5Y cells and THP1 cells, respectively.
RAC1 Protein ncbiprotein:NP_061485.1 [Pubmed:15056283] have shown that DAMGO stimulates MOR and induces activation of RAC1 in SHSY5Y and COS7 cells.
CDC42 Protein ncbiprotein:NP_001034891.1 [Pubmed:15056283] have shown that DAMGO stimulates MOR and induces activation of CDC42 in SHSY5Y and COS7 cells.
[Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces activation of CDC42 in a Gbetagamma/SRC-FAK dependent manner in THP1 cells.
OPRD1 Protein ncbiprotein:NP_000902.3 [Pubmed:10334841] have shown that DPDPE stimulates OPRD1 and induces activation of OPRD1 in CHO-K1 cells
[Pubmed:10893226] have shown that deltorphinII stimulates OPRD1 and induces phosphorylation at Ser363 in OPRD1 in HEK293 cells.
[Pubmed:10884553] have shown that DTLET stimulates OPRD1 and induces transport of OPRD1 from cell membrane to cytosol in CHO delta OR cells.
[Pubmed:18463167] have shown that DPDPE stimulates OPRD1 and induces transport of OPRD1 from plasma membrane to cytosol in HEK293 cells
[Pubmed:21422164] have shown that DPDPE stimulates OPRD1 induces transport from plasma membrane to cytosol in HEK293 cells.
SOD1 Protein ncbiprotein:NP_000445.1 [Pubmed:19709398] have shown that DADLE stimulates OPRD1 and induces increased activation of SOD1 in ischemia and reperfusion brain model of rats.
PTK2 Protein ncbiprotein:NP_001339623.1 [Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces phosphorylation of PTK2 at Y397 in THP1 and COS7 cells.
SRC Protein ncbiprotein:NP_005408.1 [Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces phosphorylation of SRC at Y416 in THP1 and COS7 cells
PTK2 Protein ncbiprotein:NP_001339623.1 [Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces phosphorylation of PTK2 at Y397 in THP1 and COS7 cells.
SRC Protein ncbiprotein:NP_005408.1 [Pubmed:14996948] have shown that U-50,488H stimulates OPRK1 and induces phosphorylation of SRC at Y416 in THP1 and COS7 cells
MAPK14 Protein ncbiprotein:NP_001306.1 [Pubmed:23965172] have shown loperamide/fentanyl/methadone/beta-endorphin/morphine stimulate OPRM1 and induce phosphorylation of MAPK14 at T180/Y182 in human T-lymphocytes
[Pubmed:20354103] have shown that DAMGO and DPDPE stimulate OPRM1 and OPRD1 respectively, and incudes activation of MAPK14 in SHSY-5Y cells.
[Pubmed: 12031654] have shown that morphine or enkephalin stimulate MOR and induce phosphorylation of MAPK14 at Thr 180/Tyr 182 in cord blood hematopoietic stem cells (CD34+ cells)
CDK5R1 Protein ncbiprotein:8851 [Pubmed:16879821] have shown that DAMGO stimulates OPRM1 and induces upregulation of CDK5R1 in SH-SY5Y cells and rat embryonic hippocampal neurons.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:17384143] have shown that deltorphin II stimulates OPRM1-OPRD1 heterodimer to induce beta arrestin 2 mediated MAPK1 phosphorylation in SKNSH cells.
[Pubmed:17384143] have shown that DAMGO stimulates OPRM1 and induces PKC mediated MAPK1 phosphorylation in CHO cells
[Pubmed:23965172] have shown that fentanyl/loperamide/morphine/beta-endorphin/methadone stimulate OPRM1 and induces phosphorylation of MAPK1 in human T-lymphocytes.
[Pubmed: 15647486] have shown that morphine stimulates MOR induces phosphorylation of MAPK1 at Thr 185/Tyr 187 in mouse microglial EOC2 cells.
[Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK1 at Thr 185/Tyr 187 under NOTCH1 in mouse spinal cord.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:17384143] have shown that DAMGO stimulates OPRM1-OPRD1 heterodimer to induce beta arrestin 2 mediated MAPK13 phosphorylation in SKNSH cells.
[Pubmed:23965172] have shown that fentanyl/loperamide/morphine/beta-endorphin/methadone stimulate OPRM1 and induces phosphorylation of MAPK3 in human T-lymphocytes.
[Pubmed:17384143] have shown that DAMGO stimulates OPRM1 and induces PKC mediated MAPK3 phosphorylation in CHO cells
[Pubmed: 15647486] have shown that morphine stimulates MOR and induces phosphorylation of MAPK3 at Thr 202/Tyr 204 in mouse microglial EOC2 cells
[Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK3 at Thr 202/Tyr 204 under NOTCH1 in mouse spinal cord.
RPS6KA1 Protein ncbiprotein:NP_002944.2 [Pubmed:17384143] have shown that DAMGO stimulates OPRM1 and OPRM1-OPRD1 heteromer and induces MAPK1/3 mediated phosphorylation of RPS6KA1 at T359/S363 in CHO cells.
GNAI2 Protein ncbiprotein:NP_002061.1 [Pubmed: 20043990] have shown that morphine stimulates MOR and induces phosphorylation of GNAI2 at S44/S144/S302 by PRKCE in HEK293 cells.
MBP Protein ncbiprotein:4155 [Pubmed:22002899] have shown that methadone/Buprenorphine stimulates MOR and induces upregulation of MBP in rat oligodendrocytes.
MAPK9 Protein ncbiprotein:NP_002743.3 [Pubmed:26056051] have shown that morphine and fentanyl stimulate OPRM1 and induce activation of MAPK9 in a Src-PKC dependent and GRK3-ARBB2, Src dependent manner respectively in C57Bl/6 mice
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:22736766] have shown that EKC/U50,488 stimulates KOR and induces association of OPRK1 and ARR3 in HEK293 cells
ARR3 Protein ncbiprotein:NP_004303.2 [Pubmed:22736766] have shown that EKC/U50488 stimulates KOR and induces association of OPRK1 and ARR3 in HEK293 cells
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:22736766] have shown that EKC/U50488 stimulates KOR and induces translocation of OPRK1 from plasma membrane to cytoplasm in HEK293T cells.
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:22736766] have shown that EKC/U50488 stimulates KOR and induces translocation of OPRK1 from plasma membrane to cytoplasm in HEK293T cells.
[Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces translocation of OPRK1 from plasma membrane to endosomein CHHO-KOR cells and mice striatal neurons.
RGS9 Protein ncbigene:8787 [Pubmed:24561386] have shown that morphine stimulates MOR and induces downregulation of RGS9 in mouse D2-type neurons.
MAPK14 Protein ncbiprotein:NP_001306.1 [Pubmed:25857454] has shown that dynorphin stimulates KOR induce phosphorylation of MAPK14 in Chinese Hamster Ovary cell line.
ARRB2 Protein ncbiprotein:NP_001244257.1 [Pubmed:25857454] have shown that dynorphin stimulates OPRK1 and induces translocation of ARBB2 from cytosol to plasma membrane in CHO cells.
CREB1 Protein ncbiprotein:NP_604391.1 [Pubmed: 10708700] have shown that morphine and DPDPE stimulates DOR induce phosphorylation of CREB1 at Ser133 in NG108-15 cells
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed: 10646507] have shown that U69,593 stimulates of OPRK1 induces phosphorylation of MAPK1 at Thr185/Tyr187 in C6 glioma cells in a Gβγ subunits and Ras dependent manner
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed: 10646507] have shown that U69,593 stimulates KOR induces phosphorylation of MAPK3 at Thr202/Tyr204 in C6 glioma cells in a Gβγ subunit and Ras dependent manner
PTK2B Protein ncbiprotein:NP_775266.1 [Pubmed:10646507] have shown that stimulation of OPRK1 with U69,593 induces Tyr phosphorylation of PTK2B in C6 glioma cell line
FTH1 Protein ncbigene:2498 [Pubmed: 19244528] have shown that Morphine and DAMGO stimulates OPRM1 and induces upregulation of FTH1 in rat cortical neurons and brain homogenates.
RGS4 Protein ncbigene:5999 [Pubmed: 22056472] have shown that morphine stimulates MOR and induces upregulation of RGS4 in rat prefrontal cortex.
MCL1 Protein ncbiprotein:4170 [Pubmed:22033345] have shown that methadone/Buprenorphine stimulates MOR and induces upregulation of MCL1 in rat oligodendrocytes.
RGS4 Protein ncbiprotein:NP_001095915.1 [Pubmed:26119705] have shown that DAMGO stimulates MOR and induces the assciation of RGS4 and OPRM1 in rat brain membrane.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:24113748] have shown that morphine stimulates MOR and induces association of FKBP1A to OPRM1 in HEK293 cells
GNAO1 Protein ncbiprotein:NP_620073.2 [Pubmed:26119705] have shown that DAMGO stimulates MOR and induces the assciation of OPRM1 and GNAO1 in rat brain membrane.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed: 10334841] have shown that DAMGO stimulates OPRM1 and induces activation of OPRM1 in CHO-K1 cells
BCL2 Protein ncbiprotein:596 [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces downregulation of BCL2 in HL60 cells
BAX Protein ncbiprotein:581 [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of BAX in HL60 cells
FAS Protein ncbiprotein:355 [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of FAS in HL60 cells
FASLG Protein ncbiprotein:356 [Pubmed: 15644942] have shown that endomorphins EM1 and EM2 stimulates MOR induces upregulation of FASLG in HL60 cells
GRK2 Protein ncbiprotein:NP_001610.2 [Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of GRK2 from cytosol to plasma membrane in BE(2)-C cells
GRK3 Protein ncbiprotein:NP_005151.2 [Pubmed: 12750434] have shown that DAMGO stimulates MOR and ORL1 receptor induces translocation of GRK3 from cytosol to plasma membrane in BE(2)-C cells
GATA4 Protein ncbigene:2626 [Pubmed: 12623878] have shown that Dynorphin stimulatesKOR induces upregulation of GATA4 gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells
NKX2-5 Protein ncbiprotein:1482 [Pubmed: 12623878] have shown that Dynorphin stimulates OPRM1 induces upregulation of NKX2-5 gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells
PDYN Protein ncbiprotein:5173 [Pubmed: 12623878] have shown that Dynorphin stimulates KOR induces upregulation of PDYN gene in a PKC dependent manner in nuclei isolated from undifferentiated ES cells
ARRB2 Protein ncbiprotein:NP_001244257.1 [Pubmed: 17565992] have shown that DPDPE stimulates association of OPRD1 with ARRB2 in HEK293 cells
ARRB1 Protein ncbiprotein:NP_004032.2 [Pubmed: 17565992] have shown that DPDPE stimulates association of OPRD1 with ARRB1 in HEK293 cells.
CD14 Protein ncbiprotein:929 [Pubmed: 17583593] have shown that morphine stimulates MOR induces downregulation of CD14 expression on the surface of human neutrophils
ADCY1 Protein ncbigene:107 [Pubmed: 23682813] have shown that DAMGO treatment stimulates OPRM1 and induces upregulation of ADCY1 in mice striatum and prefrontal cortex
ADCY8 Protein ncbigene:114 [Pubmed: 23682813] have shown that DAMGO treatment stimulates OPRM1 and induces upregulation of ADCY8 in mice striatum and prefrontal cortex
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed: 26363797] have shown that DAMGO stimulates MOR and induces molecular association of OPRM1 and NISCH in CHO cells
NISCH Protein ncbiprotein:NP_009115.2 [Pubmed: 26363797] have shown that DAMGO stimulates MOR and induces molecular association of OPRM1 and NISCH in CHO cells
SRC Protein ncbiprotein:NP_005408.1 [Pubmed: 27634008] have shown that U50488 and Dynorphin stimulates OPRK1 and induces phosphorylation of SRC at Y416 in mouse primary hippocampal neurons
GRIN2B Protein ncbiprotein:NP_000825.2 [Pubmed: 27634008] have shown that U50488 and Dynorphin stimulates KOR and induces phosphorylation of GRIN2B at Y1472 in mouse primary hippocampus
OPRK1 Protein ncbiprotein:NP_001305426.1 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces translocation of OPRK1 from plasma membrane to endosomein CHHO-KOR cells and mice striatal neurons.
[Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces molecular association of OPRK1 and ARRB2 in CHO-KOR cells and mice striatal neurons.
ARRB2 Protein ncbiprotein:NP_001244257.1 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces molecular association of OPRK1 and ARRB2 in CHO-KOR cells and mice striatal neurons.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces phosphorylation of MAPK1 in a G alpha-io dependent manner in CHO-KOR cells and mice striatal neurons.
[Pubmed:25107591] have shown that SalA, U69,593 and U50,488 stimulates OPRK1 and induces phosphorylation of MAPK1 at Thr185/Tyr187 in EM4 cells.
[Pubmed:26297384] have shown that U50,488 stimulates KOR and induces phosphorylation of MAPK1 at Thr185/Tyr187 in rat peripheral sensory neurons
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:23775075] have shown that U-69,593 stimulates KOR and induces phosphorylation of MAPK3 in a G alpha-io dependent in CHO-KOR cells and mice striatal neurons.
[Pubmed: 25107591] have shown that SalA, U69,593 and U50,488 stimulates OPRK1 and induces phosphorylation of MAPK3 at Thr202/Tyr204 in EM4 cells.
[Pubmed:26297384] have shown that U50488 stimulates KOR and induces phosphorylation of MAPK3 at Thr202/Tyr204 in rat peripheral sensory neurons
ITGAM Protein ncbiprotein:3684 [Pubmed:23844255] have shown that TAN-67 stimulates DOR and induces downregulation of ITGAM in rat cortex.
NCAM1 Protein ncbiprotein:4684 [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of NCAM1 in a STAT5B mediated manner in Neuro 2A cells.
SYP Protein ncbiprotein:6855 [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of SYP in a STAT5B mediated manner in Neuro 2A cells.
TUBB3 Protein ncbiprotein:10381 [Pubmed:23906478] have shown that DSLET stimulates DOR and induces upregulation of NCAM1 in a STAT5B mediated manner in Neuro 2A cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells.
TRPM8 Protein ncbiprotein:NP_076985.4 [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells.
TRPM8 Protein ncbiprotein:NP_076985.4 [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells.
NTRK2 Protein ncbiprotein:4915 [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of NTRK2 in rat dorsal raphe nucleus.
CRHR1 Protein ncbiprotein:1394 [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of CRHR1 in rat dorsal raphe nucleus.
HTR1A Protein ncbiprotein:3350 [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of HTR1A in rat dorsal raphe nucleus.
PRG4 Protein ncbiprotein:10216 [Pubmed:28097228] have shown that dynorphinA/U-50,488H stimulates KOR and induces upregulation of PRG4 in a cAMP/PKA alpha/CREB dependent manner in human chondrocytes.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:22375000] have shown that DAMGO stimulates OPRM1 and induces translocation of OPRM1 from plasma membrane to cytosol in human neuroblastoma SH-SY5Y cells.
[Pubmed:31575621] have shown that DAMGO stimulates OPRM1 and induces phosphorylation of OPRM1 at Ser 363 in a G beta-gamma/PLC/PKC mediated manner in HEK293 cells
ARRB2 Protein ncbiprotein:NP_001244257.1 [Pubmed:22375000] have hown that DAMGO stimulates MOR and induces translocation of ARRB2 from cytosol to plasma membrane in SH-SY5Y cells.
[Pubmed: 22079772] have shown that co-administration of morphine and fentanyl stimulates OPRM1 and induces activation of ARRB2 in rat brain locus coeruleus and periaqueductal gray section
ARRB1 Protein ncbiprotein:NP_004032.2 [Pubmed:22375000] have shown that DAMGO stimulates MOR and induces association of OPRM1 and ARRB1 in human neuroblastoma SH-SY5Y cells
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:22375000] have shown that DAMGO stimulates MOR and induces association of OPRM1 and ARRB1 in human neuroblastoma SH-SY5Y cells
MAPK14 Protein ncbiprotein:NP_001306.1 Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces phosphorylation of MAPK14 on Thr/Tyr at 180/182 in a MEK/ERK dependent manner in mouse astrocyte culture.
SLC1A3 Protein ncbiprotein:6507 [Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces upregulation of SLC1A3 protein in mouse astrocyte cultures
SLC1A2 Protein ncbiprotein:6506 [Pubmed:25052197] have shown that UFP-512 stimulates DOR and induces upregulation of SLC1A2 protein in mouse astrocyte cultures
ECE2 Protein ncbiprotein:9718 [Pubmed:24990314] have shown that DAMGO/dynorphin B stimulates MOR and induces upregulation of ECE2 in CHO cells.
ECE2 Protein ncbiprotein:9718 [Pubmed:24990314] have shown that DAMGO/dynorphin B stimulates MOR and induces upregulation of ECE2 in CHO cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:22375000] have shown that DAMGO stimulates MOR and induces association of OPRM1 and ARRB1 in human neuroblastoma SH-SY5Y cells
ECE2 Protein ncbiprotein:9718 [Pubmed:24990314] have shown that DAMGO/dynorphin B stimulates MOR and induces upregulation of ECE2 in CHO cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:24990314] have shown that DAMGO/fentanyl/dynorphin B stimulates MOR and induces translocation (recycling) of OPRM1 from endosome to plasma membrane in CHO and F11 cells.
[Pubmed:31575621] have shown that DAMGO stimulates OPRM1 and induces translocation of OPRM1 from endosome to plasma membranel in HEK293 cells
KDR Protein ncbiprotein:3791 [Pubmed:21460241] have shown that U-50,488H/TRK820 stimulates KOR and induces Gi/cAMP/PKA mediated downregulation of KDR in mouse endothelial cels.
NRP1 Protein ncbiprotein:8829 [Pubmed:21460241] have shown that U-50,488H/TRK820 stimulates KOR and induces Gi/cAMP/PKA mediated downregulation of NRP1 in mouse endothelial cels.
AIF1 Protein ncbiprotein:199 [Pubmed:19176808] have shown that morphine stimulates MOR and induces upregulation of AIF1 in rat microglia.
P2RX4 Protein ncbiprotein:5025 [Pubmed:19176808] have shown that morphine stimulates MOR and induces upregulation of P2RX4 in rat microglia.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of MAPK1 in HaCaT cells.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of MAPK3 in HaCaT cells.
RPS6KA1 Protein ncbiprotein:NP_002944.2 [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of RPS6KA1 in HaCaT cells.
ELK1 Protein ncbiprotein:NP_001107595.1 [Pubmed: 26763532] have shown that leucine-enkephalin stimulates DOR and induces phosphorylation of ELK1 in HaCaT cells.
MMP2 Protein ncbiprotein:4313 [Pubmed:26763532] have shown that leucin enkephalin stimulates DOR and induces upregulation of MMP2 in HaCaT cells.
MMP9 Protein ncbiprotein:4318 [Pubmed:26763532] have shown that leucin enkephalin stimulates DOR and induces upregulation of MMP9 in HaCaT cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:20214800] have shown that morphine stimulates MOR and induces association of OPRM1 and WLS in HEK293 cells.
WLS Protein ncbiprotein:NP_001002292.3 [Pubmed:20214800] have shown that morphine stimulates MOR and induces association of OPRM1 and WLS in HEK293 cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:20214800] have shown that morphine stimulates MOR and induces association of OPRM1 and WLS in HEK293 cells.
WLS Protein ncbiprotein:NP_001002292.3 [Pubmed:20214800] have shown that morphine stimulates MOR and induces association of OPRM1 and WLS in HEK293 cells.
OPRL1 Protein ncbigene:4987 [Pubmed:16311589] have shown that nociceptin stimulates ORL1 and induces translocation of OPRL1-CACNA1B complex from cell membrane to cytosol in CHO cells and rat DRG neurons.
E2F1 Protein ncbigene:1869 [Pubmed:19765550] have shown that morphine stimulates MOR and induces upregulation of E2F1 in CEMx174 cells.
E2F1 Protein refseq:NP_005216.1 [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and YY1 in CEMx174 cells.
YY1 Protein ncbiprotein:NP_003394.1 [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and YY1 in CEMx174 cells.
E2F1 Protein refseq:NP_005216.1 [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and SP1 in CEMx174 cells.
SP1 Protein ncbiprotein:NP_612482.2 [Pubmed:19765550] have shown that morphine stimulates MOR and induces association of E2F1 and SP1 in CEMx174 cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells.
E2F1 Protein refseq:NP_005216.1 [Pubmed:19765550] have shown that morphine stimulates MOR and induces the DNA binding of E2F1 to MOR promoter in CEMx174 cells.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:23911290] have shown that morphine stimulates MOR and induces association of OPRM1 and TRPM8 in HEK293 cells.
RGS9 Protein refseq:NP_001075424.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces phosphorylation of RGS9 at S475 in mouse PAG synaptosomes
RGS9 Protein refseq:NP_001075424.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces phosphorylation of RGS9 at S475 in mouse PAG synaptosomes
RGS9 Protein refseq:NP_001075424.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces phosphorylation of RGS9 at S475 in mouse PAG synaptosomes
RGS9 Protein refseq:NP_001075424.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces phosphorylation of RGS9 at S475 in mouse PAG synaptosomes
GNAI2 Protein refseq:NP_002061.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and GNAI2 in mouse PAG synaptosomes
GNAZ Protein refseq:NP_002064.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and GNAZ in mouse PAG synaptosomes
YWHAQ Protein refseq:NP_006817.1 [Pubmed:15632124] have shown that morphine stimulates MOR and induces association of RGS9 and YWHAQ in mouse PAG synaptosomes
SRC Protein ncbiprotein:NP_005408.1 [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces phosphorylation of SRC at Y416 in rabbit cultured smooth muscle cells
GNAI2 Protein ncbiprotein:NP_002061.1 [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces association of GNAI2 and RGS12 in a Gbeta/gamma-PI2K-cSRC mediated manner in rabbit cultured smooth muscle cells.
RGS12 Protein ncbiprotein:NP_937872.1 [Pubmed:24578342] have shown that DPDPE stimulates DOR and induces association of GNAI2 and RGS12 in a Gbeta/gamma-PI2K-cSRC mediated manner in rabbit cultured smooth muscle cells.
GNAI2 Protein ncbigene:2771 [Pubmed:15987828] have shown that DAMGO stimulates MOR and induces downregulation of GNAI2 in CHO cells.
NEU2 Protein ncbigene:4759 [Pubmed:15987828] have shown that morphine stimulates MOR and induces downregulation of NEU2 in CHO cells.
GNA12 Protein ncbigene:2768 [Pubmed:15987828] have shown that DAMGO stimulates MOR and induces upregulation of GNA12 in CHO cells.
RPLP2 Protein ncbigene:6181 [Pubmed:15987828] have shown that morphine stimulates MOR and induces downregulation of RPLP2 in CHO cells.
JUP Protein ncbigene:3728 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of JUP in CHO cells.
PGM1 Protein ncbigene:5236 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of PGM1 in CHO cells.
UBQLN1 Protein ncbiprotein:29979 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of UBQLN1 in CHO cells.
TUBB Protein ncbigene:203068 [Pubmed:15987828] have shown that morphine stimulates MOR and induces upregulation of TUBB in CHO cells.
HSPA8 Protein ncbigene:3312 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of HSPA8 in CHO cells.
ALDH9A1 Protein ncbigene:223 [Pubmed:15987828] have shown that morphine stimulates MOR and induces up regulation of ALDH9A1 in CHO cells.
CAMK2A Protein ncbiprotein:NP_057065.2 [Pubmed:16697745] have shown that DPDPE stimulates DOR and induces CAMK2A phosphorylation at Thr286 in rat BDL cholangiocytes
PCNA Protein ncbigene:511
PRKCA Protein ncbiprotein:NP_002728.1 [Pubmed:16697745] have shown that DPDPE stimulates DOR and induces PRKCA phosphorylation at Ser 657 in rat BDL cholangiocytes
PCNA Protein ncbigene:511
ARC Protein ncbigene:23237 [Pubmed:16211563] have shown that morphine stimulates MOR and induces upregulation of ARC in a PKC/MEK dependent manner in mouse striatum and Neuro2A cells.
GCK Protein ncbiprotein:2645 [Pubmed:16140165] have shown that tramadol stimulates OPRM1 and induces upregulation of GCK in rat cortex and hypothalamus.
IRS2 Protein ncbiprotein:8660 [Pubmed:16140165] have shown that tramadol stimulates OPRM1 and induces upregulation of IRS2 in rat primary neuronal cells.
NEUROD1 Protein ncbiprotein:4790 [Pubmed:20554861] have shown that fentanyl stimulates MOR and induces upregulation of NEUROD1 in rat hippocampal neurons.
ADM Protein ncbiprotein:133 [Pubmed:20844145] have shown that morphine stimulates MOR and induces upregulation of ADM in a PKC mediated manner in rat DRG neurons.
CALCA Protein ncbiprotein:796 [Pubmed:20844145] have shown that morphine stimulates MOR and induces upregulation of CALCA in a PKC mediated manner in rat DRG neurons.
GJA1 Protein ncbiprotein:2697 [Pubmed:23011166] have shown that U50,488H stimulates KOR and induces upregulation of GJA1 mRNA in rat ventricles.
GFAP Protein ncbiprotein:2670 [Pubmed: 25806604] have shown that morphine stimulates MOR and induces the upregulation of GFAP in mouse spinal cord.
ARR3 Protein ncbiprotein:NP_004303.2 [Pubmed:22553358] have shown that morphine stimulates MOR and induces OPRM1 and ARR3 association in HEK293 cells
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:22553358] have shown that morphine stimulates MOR and induces OPRM1 and ARR3 association in HEK293 cells
PIK3R1 Protein ncbiprotein:5295 [Pubmed: 18588537] have shown that chronic morphine treatment stimulates MOR and induces upregulation of PIK3R1 in mouse central extended amygdala
GNAI3 Protein ncbiprotein:NP_006487.1 [Pubmed:24976397] have shown that DAMGO, deltorphinII and DPDPE stimulates MOR, MOR-DOR heteromer and DOR respectively and induces activation of GNAI3 in rat striatum and hippocampi
SLC6A4 Protein ncbiprotein:NP_001036.1 [Pubmed:25107591] have shown that SalA stimulates KOR and induces activation of SLC6A4 in EM4 cells
MAPK8 Protein ncbiprotein:NP_001265476.1 [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of MAPK8 at Tyr 185 in mouse spinal cord.
NOTCH1 Protein ncbiprotein:4851 [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of NOTCH1 in mouse spinal cord
PRKCE Protein ncbigene:5581 [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of PRKCE in mouse spinal cord.
PRKCG Protein ncbigene:5582 [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of PRKCG in mouse spinal cord.
HDAC1 Protein ncbigene:3065 [Pubmed:31347026] have shown that morphine stimulates MOR and induces downregulation of HDAC1 in mouse spinal cord.
DNMT3A Protein ncbigene:1788 [Pubmed:31347026] have shown that morphine stimulates MOR and induces upregulation of DNMT3A in mouse spinal cord.
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:31347026] have shown that morphine stimulates MOR and induces molecular association of OPRM1 and HDAC1 in mouse spinal cord.
PRKCE Protein ncbiprotein:NP_005391.1 [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of PRKCE at Ser 729 in mouse spinal cord.
PRKCG Protein ncbiprotein:NP_001303258.1 [Pubmed:31347026] have shown that morphine stimulates MOR and induces phosphorylation of PRKCG at Thr 512 in mouse spinal cord.
HMOX1 Protein ncbigene:3162 [Pubmed:30595095] have shown that dynorphin A stimulates KOR and induces upregulation of HMOX1 in rat hippocampal neurons.
MAP1LC3B Protein ncbigene:81631 [Pubmed:32955950] have shown that BW373U86 stimulates DOR and induces upregulation of MAP1LC3B in hypoxic rat cardiomyocytes.
SQSTM1 Protein ncbigene:8878 [Pubmed:32955950] have shown that BW373U86 stimulates DOR and induces downregulation of SQSTM1 in hypoxic rat cardiomyocytes.
MAPK14 Protein ncbiprotein:NP_001306.1 [Pubmed:10501195] have shown that DPDPE or N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK14 at Thr 180 /Tyr 182 in a PKA dependent manner in NG108-15 cells.
ATF2 Protein ncbiprotein:NP_001871.2 [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of ATF2 downstream of MAPK14 in NG108-15 cells.
MBP Protein ncbigene:4155 [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce upregulation of MBP downstream of MAPK14 in NG108-15 cells.
HDAC1 Protein ncbigene:3065 [Pubmed:31347026] have shown that morphine stimulates MOR and induces molecular association of OPRM1 and HDAC1 in mouse spinal cord.
MAPK1 Protein ncbiprotein:NP_002736.3 [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK1 at Thr185 and Tyr187 in a PKC dependent manner in NG108-15 cells.
MAPK3 Protein ncbiprotein:NP_002736.3 [Pubmed:10501195] have shown that DPDPE and N/OFQ stimulate DOR and ORL1 respectively and induce phosphorylation of MAPK3 at Thr202 and Tyr204 in a PKC dependent manner in NG108-15 cells
OPRM1 Protein ncbiprotein:NP_001138751.1 [Pubmed:24061856] have shown that morphine stimulates MOR and induces phosphorylation of OPRM1 at Tyr336 in HEK293 cells.
KRAS Protein ncbiprotein:NP_004976.2 [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces activation of KRAS in HEK293 cells
SRC Protein ncbiprotein:NP_005408.1 Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of SRC at Tyr416 in HEK293 cells.
RAF1 Protein ncbiprotein:NP_001341618.1 [Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces activation of RAF1 in HEK293 cells.
[Pubmed:24061856] have shown that morphine stimulates OPRM1 and induces phosphorylation of RAF1 at Tyr340/341 in HEK293 cells
BDNF Protein ncbiprotein:627 [Pubmed:24055683] have shown that morphine stimulates MOR and induces downregulation of BDNF in rat dorsal raphe nucleus.

References

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