MYD88 distinct input-output pathway (WP3877)
This pathway is based on figure 7 from Li et al. Formation of MyD88 dimer catalyzes formation of IRAK1/TRAF6 complex. UEV1A and Ubc13 ubiquinate TRAF6 which allow for the activation of NFKB and AP-1 through canonical IKK phosphorylation. This complex also induces the production of reactive oxygen species. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3877 CPTAC Assay Portal].
AuthorsAAR&Co , Friederike Ehrhart , Kristina Hanspers , and Eric Weitz
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- Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma (2022).
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Pathway OntologyToll-like receptor signaling pathway signaling pathway
- Identification of potential pathway mediation targets in Toll-like receptor signaling. Li F, Thiele I, Jamshidi N, Palsson BØ. PLoS Comput Biol. 2009 Feb;5(2):e1000292. PubMed Europe PMC Scholia