Iron-sulfur cluster biogenesis (WP5152)

Homo sapiens

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This pathway describes the biogenesis of iron-sulphur clusters. Iron-sulphur clusters bind to proteins and are essential components of respiratory electron transfer complexes as well as many other biological processes. This pathway was modeled based on Fig 2a from [https://pubmed.ncbi.nlm.nih.gov/18606475/ Rouault and Tong].

Authors

Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

iron-sulfur cluster protein biogenesis pathway regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
e- Metabolite chebi:10545
L-cysteine Metabolite chebi:17561
Fe Metabolite chebi:18248
[4Fe-4S] cluster Metabolite chebi:49883
S Metabolite chebi:26833
Fe Metabolite chebi:18248
Fe Metabolite chebi:18248
Fe Metabolite chebi:18248
[4Fe-4S] cluster Metabolite chebi:49883
NFS1 GeneProduct ncbigene:9054
LYRM4 GeneProduct ncbigene:57128
ISCU GeneProduct ncbigene:23479
FXN GeneProduct ncbigene:2395
FDX1 GeneProduct ncbigene:2230
FDXR GeneProduct ncbigene:2232
ABCB7 GeneProduct ncbigene:22
HSPA9 GeneProduct ncbigene:3313
HSCB GeneProduct ncbigene:150274
GLRX5 GeneProduct ncbigene:51218
NUBP2 GeneProduct ncbigene:10101
NUBP1 GeneProduct ncbigene:4682
NARF GeneProduct ncbigene:26502
CIAO1 GeneProduct ncbigene:4682
CIAO2B GeneProduct ncbigene:51647
FXN GeneProduct ncbigene:2395
NFU1 GeneProduct ncbigene:27247
NFS1 GeneProduct ncbigene:9054
ISCU GeneProduct ncbigene:23479
ISCU GeneProduct ncbigene:23479

References

  1. Iron-sulfur cluster biogenesis and human disease. Rouault TA, Tong WH. Trends Genet. 2008 Aug;24(8):398–407. PubMed Europe PMC Scholia
  2. The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1. Friemel M, Marelja Z, Li K, Leimkühler S. Biochemistry. 2017 Mar 28;56(12):1797–808. PubMed Europe PMC Scholia