Lipid particles composition (WP3601)
Homo sapiens
This particle describes the chemical composition of various lipid particles. See also [https://www.wikipathways.org/index.php/Pathway:WP430] for a basic overview of cholesterol synthesis, and for the disease related to the lipoproteins in this pathway see [https://www.wikipathways.org/index.php/Pathway:WP4522]. Additional sources - A. Goldberg, Overview of Lipid Metabolism, 2015. http://www.msdmanuals.com/professional/endocrine-and-metabolic-disorders/lipid-disorders/overview-of-lipid-metabolism
Authors
Egon Willighagen , Anders Riutta , Denise Slenter , and Eric WeitzActivity
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Cited In
- Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus (2021).
- Identification of candidate genes and pathways in retinopathy of prematurity by whole exome sequencing of preterm infants enriched in phenotypic extremes (2021).
- Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients (2022).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
lipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ROS | Metabolite | chebi:26523 | |
| cholesterylester | Metabolite | chebi:17002 | |
| HDL | Metabolite | chebi:39025 | |
| cholesterol | Metabolite | hmdb:HMDB0000067 | |
| TG | Metabolite | chebi:17855 | |
| FA | Metabolite | chebi:35366 | |
| LDL | Metabolite | chebi:39026 | |
| VLDL | Metabolite | chebi:39027 | |
| cholesterylester | Metabolite | chebi:17002 | |
| TG | Metabolite | chebi:17855 | |
| glycerol | Metabolite | hmdb:HMDB0000131 | |
| cholesterol | Metabolite | hmdb:HMDB0000067 | |
| cholesterol | Metabolite | hmdb:HMDB0000067 | |
| cholesterol | Metabolite | hmdb:HMDB0000067 | |
| oxLDL | Metabolite | chebi:60151 | |
| cholesterol | Metabolite | hmdb:HMDB0000067 | |
| CETP | GeneProduct | ensembl:ENSG00000087237 | |
| LDLR | GeneProduct | ensembl:ENSG00000130164 | |
| LCAT | GeneProduct | ensembl:ENSG00000213398 | |
| LPL | GeneProduct | ensembl:ENSG00000175445 | |
| Apo C-III | Protein | uniprot:P02656 | |
| Apo C-II | Protein | uniprot:P02655 | |
| Apo A-II | Protein | uniprot:P02652 | |
| Apo E | Protein | uniprot:P02649 | |
| Apo A-I | Protein | uniprot:P02647 | |
| Apo B-100 | Protein | uniprot:P04114 | |
| Apo E | Protein | uniprot:P02649 | |
| Apo C-II | Protein | uniprot:P02655 | |
| Apo C-III | Protein | uniprot:P02656 | |
| Apo E | Protein | uniprot:P02649 | |
| Apo C-II | Protein | uniprot:P02655 | |
| Apo C-III | Protein | uniprot:P02656 | |
| Apo E | Protein | uniprot:P02649 |
References
- Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Mahley RW. Science. 1988 Apr 29;240(4852):622–30. PubMed Europe PMC Scholia
- Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis. Steinberg D. Circulation. 1997 Feb 18;95(4):1062–71. PubMed Europe PMC Scholia