Microglia pathogen phagocytosis pathway (WP3626)
Mus musculus
Pathogens are recognized by complement C1q or immunoglobulin (IgG) that bind to microglia complement receptors (e.g., ITGAM/ITGB2) or Fc-receptors (e.g., FCGR1) that signal via the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor molecules TYROBP or FCER1G, respectively. Alternatively, pathogens are directly recognized by classical innate immune receptors (e.g., TREM2) that require the interaction with TYROBP for further signaling. This pathway was converted from the original human pathway to mouse.
Authors
Kristina Hanspers , Alex Pico , Denise Slenter , Egon Willighagen , and Eric WeitzActivity
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Cited In
- Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques (2020).
- Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration (2018).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
innate immune response pathway Alzheimer's disease pathwayCell Type Ontology
microglial cellReferences
- Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, et al. Cell. 2013 Apr 25;153(3):707–20. PubMed Europe PMC Scholia