Neovascularization processes (WP4331)
Homo sapiens
Neovascularization (aka new vessel formation) is a crucial process related to wound healing. It supplies oxygen and nutrients to, and carries waste from, damaged tissue. Angiogenesis is a type of neovascularization, being a vital process in growth, development, and wound healing.
Authors
Carlos Alberto Xavier Gonalves , Friederike Ehrhart , Denise Slenter , Eric Weitz , and Egon WillighagenActivity
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Cited In
- Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease (2022).
- Cellular and Molecular Heterogeneity Associated with Vessel Formation Processes (2018).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
cardiovascular system homeostasis pathwayCell Type Ontology
pericyte cell smooth muscle cell endothelial cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Notch1 | GeneProduct | uniprot:P46531 | |
| VEGFR3 | GeneProduct | ensembl:ENSG00000037280 | aka FLT4 |
| VEGFR2 | GeneProduct | ensembl:ENSG00000128052 | aka KDR |
| VEGF | GeneProduct | interpro:IPR000072 | |
| FAK | GeneProduct | interpro:IPR036137 | |
| EPHB4 | GeneProduct | ensembl:ENSG00000196411 | |
| MMP9 | GeneProduct | ensembl:ENSG00000100985 | |
| mKitL | GeneProduct | ensembl:ENSG00000049130 | 'The ligand for the c-Kit receptor, KitL, exists as a membrane-associated (mKitL) and a soluble form (sKitL).' [PMID:30410062]. Annotated with KitL, since no separate IDs could be found. |
| sKitL | GeneProduct | ensembl:ENSG00000049130 | 'The ligand for the c-Kit receptor, KitL, exists as a membrane-associated (mKitL) and a soluble form (sKitL).' [PMID:30410062]. Annotated with KitL, since no separate IDs could be found. |
| cKit | GeneProduct | ensembl:ENSG00000157404 | aka SCFR |
| DLL4 | GeneProduct | ensembl:ENSG00000128917 | |
| JAG1 | GeneProduct | ensembl:ENSG00000101384 | |
| NOTCH3 | GeneProduct | ensembl:ENSG00000074181 | |
| CXCR4 | GeneProduct | ensembl:ENSG00000121966 | |
| SDF-1 | GeneProduct | ensembl:ENSG00000107562 | |
| EPHB4 | GeneProduct | ensembl:ENSG00000196411 | |
| PDGF-BB | GeneProduct | interpro:IPR000072 | 'Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF-BB), or one of each (PDGF-AB).' SOucre: [https://en.wikipedia.org/wiki/Platelet-derived_growth_factor]. Annotated with enzyme family identifier. |
| ANGPT1 | GeneProduct | ensembl:ENSG00000154188 | |
| VEGFR | GeneProduct | uniprot:IPR009135 | |
| HIF1A | GeneProduct | ensembl:ENSG00000100644 | |
| TGFB1 | GeneProduct | ensembl:ENSG00000105329 | |
| TGFB2 | GeneProduct | ensembl:ENSG00000092969 | |
| TGFB3 | GeneProduct | ensembl:ENSG00000119699 | |
| SMAD1 | GeneProduct | ensembl:ENSG00000170365 | |
| SMAD2 | GeneProduct | ensembl:ENSG00000175387 | |
| TGFBR1 | GeneProduct | ensembl:ENSG00000106799 | |
| ALK1 | GeneProduct | ensembl:ENSG00000139567 | aka ACVRL1 |
| ALK5 | GeneProduct | ensembl:ENSG00000106799 | aka TGFBR1 |
| EPHB2 | GeneProduct | ensembl:ENSG00000133216 | |
| ERK1 | GeneProduct | ensembl:ENSG00000102882 | AKA MAPK3 |
| ERK2 | GeneProduct | ensembl:ENSG00000100030 | AKA MAPL1 |
| PI3K | GeneProduct | interpro:IPR000403 | |
| AKT1 | GeneProduct | ensembl:ENSG00000142208 | |
| JNK2 | GeneProduct | uniprot:P45984 | AKA MAPK9, Source: [https://www.uniprot.org/uniprot/P45984] |
| JNK1 | GeneProduct | ensembl:ENSG00000107643 | AKA MAPK8 |
| SMAD5 | GeneProduct | ensembl:ENSG00000113658 | |
| Smad8 | GeneProduct | ensembl:ENSG00000120693 | aka Mothers against decapentaplegic homolog 9 also known as SMAD9, SMAD8, and MADH6 |
| SMAD3 | GeneProduct | ensembl:ENSG00000166949 | |
| PDGF-beta | GeneProduct | ensembl:ENSG00000100311 | |
| Notch4 | GeneProduct | uniprot:Q99466 | |
| SDF- | GeneProduct | ensembl:ENSG00000107562 | |
| NFKB1 | Protein | uniprot:P19838 | |
| NFKB2 | Protein | uniprot:Q00653 | |
| RELA | Protein | uniprot:Q04206 | |
| RELB | Protein | uniprot:Q01201 | |
| REL | Protein | uniprot:Q04864 |
References
- Fibroblast growth factor regulation of neovascularization. Murakami M, Simons M. Curr Opin Hematol. 2008 May;15(3):215–20. PubMed Europe PMC Scholia