Estrogen metabolism (WP5276)

Homo sapiens

Authors

Conroy lipids , Egon Willighagen , Lina Schiffer , Denise Slenter , and William J Griffiths

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

steroid biosynthetic pathway lipid metabolic pathway classic metabolic pathway

References

1. Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium. Lépine J, Bernard O, Plante M, Têtu B, Pelletier G, Labrie F, et al. J Clin Endocrinol Metab. 2004 Oct;89(10):5222–32. PubMed Europe PMC Scholia
2. Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol. Sneitz N, Vahermo M, Mosorin J, Laakkonen L, Poirier D, Finel M. Drug Metab Dispos. 2013 Mar;41(3):582–91. PubMed Europe PMC Scholia
3. Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7. Kallionpää RA, Järvinen E, Finel M. J Steroid Biochem Mol Biol. 2015 Nov;154:104–11. PubMed Europe PMC Scholia
4. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, et al. J Steroid Biochem Mol Biol. 2019 Nov;194:105439. PubMed Europe PMC Scholia