Pentose phosphate pathway (WP282)

Rattus norvegicus

Pentose phosphate, phosphogluconate, or hexose monophsphate pathway oxidizes glucose-6-phosphate to fructose-6-phosphate and glyceraldehyde-3-P. NADP+ is the electron acceptor. The pathways yields NADPH as well as 5, 4, and 7 carbon intermediaries for synthesis of nucleotides.


Kdahlquist , Manny Ramirez , Daniela Digles , Martina Summer-Kutmon , Agustin Gonzalez-Vicente , Denise Slenter , Kristina Hanspers , Egon Willighagen , Eric Weitz , and Lars Willighagen


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Rattus norvegicus



Pathway Ontology

pentose phosphate pathway


Label Type Compact URI Comment
Sedoheptulose-7-Phosphate Metabolite cas:2646-35-7
Fructose-6-Phosphate Metabolite cas:643-13-0
Xylulose-5-Phosphate Metabolite cas:60802-29-1
Glyceraldehyde-3-phosphate Metabolite hmdb:HMDB0001112
D-Ribose-5-Phosphate Metabolite cas:3615-55-2
6-Phosphogluconate Metabolite hmdb:HMDB0001316
Erythrose-4-Phosphate Metabolite hmdb:HMDB0001321
Ribulose-5-Phosphate Metabolite cas:4151-19-3
Glucose-6-Phosphate Metabolite cas:59-56-3
Glyceraldehyde-3-phosphate Metabolite hmdb:HMDB0001112
6-Phosphonoglucono-delta-lactone Metabolite hmdb:HMDB0001127
Fructose-6-Phosphate Metabolite hmdb:HMDB0000124
G6pd GeneProduct ncbigene:24377
Pgls GeneProduct ncbigene:290636
Rpe GeneProduct ncbigene:501157
Taldo1 GeneProduct ncbigene:83688
Rpia GeneProduct ncbigene:362383
Tkt GeneProduct ncbigene:64524
Pgd GeneProduct ncbigene:100360180
Tkt GeneProduct ncbigene:64524


  1. Biochemistry [Internet]. Voet D. John Wiley & Sons; 1990. 228 p. Available from: OpenLibrary Worldcat