IL-9 signaling pathway (WP974)

Bos taurus

IL-9 is a multifunctional cytokine, belong to a family of cytokines. IL-9 was initially reported as a T cell growth factor in mice. It is now known to target multiple cell types. It plays an important role in the expansion and recruitment of mast cells in response to intestinal nematode infection or during autoimmune encephalomyelitis. It is also known to act on various cell types known to be involved in asthma including T cells, B cells, mast cells, eosinophils, neutrophils, and epithelial cells. IL 9 can promote the expression of TGF-beta in lipopolysaccharide induced monocytes and macrophages. IL-9 is also known to play important roles in conditions including airway inflammation, EAE and parasitic infections. Mitogen-activated protein kinase pathway is activated transiently by IL-9, which in turn leads to the growth stimulation of hematopoietic cell lines. IL-9 signals through the heterodimeric receptor composed of a specific chain (IL-9R) and a gamma chain (IL2RG), which is shared between IL-2, IL-4, IL-7, IL15 and IL-21. The IL-9R and IL-2RG associates with JAK1 and JAK3 respectively. Receptor engagement results in JAK1- JAK3 cross phosphorylation and activation of the JAK proteins which leads to the activation of Signal transducer and activator of transcription (STAT-1, STAT-3 and STAT-5) and Insulin receptor substrate 1 and 2 (IRS1 and IRS2)/PI3K cascades. IL-9 stimulation also results in the activation of MEK/ERK signaling cascade. Please access this pathway at [http://www.netpath.org/netslim/IL_9_pathway.html NetSlim] database. If you use this pathway, please cite the following paper: Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Authors

Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

interleukin-9 signaling pathway Interleukin mediated signaling pathway

Participants

Label Type Compact URI Comment
STAT1 Protein ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT5B Protein ensembl:ENSBTAG00000010125 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777
MAPK3 Protein ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
GRB2 Protein ensembl:ENSBTAG00000004736 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
STAT3 Protein ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT5A Protein ensembl:ENSBTAG00000009496 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
CDK9 Protein ensembl:ENSBTAG00000004695 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1025
MAPK1 Protein ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
IL9 Protein ensembl:ENSBTAG00000018290 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3578
JAK3 Protein ensembl:ENSBTAG00000020904 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3718
IL2RG Protein ensembl:ENSBTAG00000007626 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3561
MAP2K2 Protein ensembl:ENSBTAG00000024450 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
PIK3R1 Protein ensembl:ENSBTAG00000010989 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
JAK1 Protein ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
IL9R Protein ensembl:ENSBTAG00000007558 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3581
MAP2K1 Protein ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604

References

  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia