Diclofenac metabolic pathway (WP3152)

Bos taurus

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CYP metabolism of the diclofenac drug.

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

phase I biotransformation pathway via cytochrome P450

Participants

Label Type Compact URI Comment
diclofenac Metabolite pubchem.compound:3033
3'-Hydroxydiclofenac Metabolite pubchem.compound:112230
4'-hydroxydiclofenac Metabolite pubchem.compound:116545
5-hydroxydiclofenac Metabolite pubchem.compound:3052566
Metabolite Metabolite pubchem.compound:10065052
4',5-Dihydroxydiclofenac Metabolite pubchem.compound:3052567
CYP2B6 Protein ensembl:ENSBTAG00000003871 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P20813
CYP2C8 Protein ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10632
CYP2C18 Protein ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P33260
CYP2C19 Protein ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P33261

References

  1. Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J. Biochem Pharmacol. 1999 Sep 1;58(5):787–96. PubMed Europe PMC Scholia