Gut-liver indole metabolism (WP3627)

Homo sapiens

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Dietary tryptophane is metabolised by the gut microbiome to indole and IPA which reaches the human blood system. Indole is further metabolized into indoxyl sulfate which also reached the blood.

Authors

Egon Willighagen , Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
indoxyl Metabolite chebi:17840
IPA Metabolite chebi:43580
indole Metabolite chebi:16881
dietarytryptophan Metabolite chebi:27897
indole Metabolite chebi:16881
indole Metabolite chebi:16881
IPA Metabolite chebi:43580
indoxyl sulfate Metabolite chebi:43355
indoxyl sulfate Metabolite chebi:43355
tryptophanase GeneProduct eccode:4.1.99.1
CYP2E1 GeneProduct ensembl:ENSG00000130649

References

  1. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, et al. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698–703. PubMed Europe PMC Scholia