Ovarian infertility (WP273)

Mus musculus

Ovarian ’bottleneck’ genes associated with infertility 
 A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility phenotypes. The individual gene pages in the OKdb (Ovarian Kaleidoscope Database: http://ovary.stanford.edu) contain information on associated fertility phenotypes sorted by ovarian and nonovarian defects and by subfertility or infertility. If one searches for null mutations (under ’mutation type’) causing infertility (’infertile - ovarian defect’, under ’female fertility status’) in mice (under ’species’), 44 gene entries are found. The expression of these infertility genes in the oocyte and granulosa cells together with their cellular localization is presented in Ovarian Infertility gene map. The theca cell genes are not presented because most publications emphasize granulosa cell studies.


Izhar Ben-Shlomo , Aaron Hsueh , Martina Summer-Kutmon , Friederike Ehrhart , and Eric Weitz


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Mus musculus



Pathway Ontology

urogenital disease pathway

Disease Ontology


Cell Type Ontology

granulosa cell oocyte


Label Type Compact Identifier Comment
Bmpr1b GeneProduct ncbigene:12167
Prlr GeneProduct ncbigene:19116
Fshr GeneProduct ncbigene:14309
Lhcgr GeneProduct ncbigene:16867
Zp3 GeneProduct ncbigene:22788
Zp3 GeneProduct ncbigene:22788
Dmc1 GeneProduct ncbigene:13404
Atm GeneProduct ncbigene:11920
Mlh1 GeneProduct ncbigene:17350
Msh5 GeneProduct ncbigene:17687
Gdf9 GeneProduct ncbigene:14566
Zp2 GeneProduct ncbigene:22787
Smpd1 GeneProduct ncbigene:20597
Dazl GeneProduct ncbigene:13164
Gja4 GeneProduct ncbigene:14612
Gja4 GeneProduct ncbigene:14612
Inha GeneProduct ncbigene:16322
Smad3 GeneProduct ncbigene:17127
Pgr GeneProduct ncbigene:18667
Esr2 GeneProduct ncbigene:13983
Vdr GeneProduct ncbigene:22337
Nr5a1 GeneProduct ncbigene:26423
Tbp GeneProduct ncbigene:21374
Ncor1 GeneProduct ncbigene:20185
Nrip1 GeneProduct ncbigene:268903
Egr1 GeneProduct ncbigene:13653
Cebpb GeneProduct ncbigene:12608
Ptger2 GeneProduct ncbigene:19217
Cdkn1b GeneProduct ncbigene:12576
Ccnd2 GeneProduct ncbigene:12444
Cdk4 GeneProduct ncbigene:12567
Smpd1 GeneProduct ncbigene:20597
Cyp19a1 GeneProduct ncbigene:13075
Syne2 GeneProduct ncbigene:319565