EGFR1 signaling pathway (WP752)

Gallus gallus

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The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Authors

Michiel Adriaens , Alex Pico , Christine Chichester , and Eric Weitz

Activity

last edited

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

epidermal growth factor/neuregulin signaling pathway

Participants

Label Type Compact URI Comment
EGF GeneProduct ncbigene:408035
RAF1 GeneProduct ncbigene:396245
HRAS GeneProduct ncbigene:396229
NRAS GeneProduct ncbigene:419885
KRAS GeneProduct ncbigene:418207
SHOC2 GeneProduct ncbigene:423894
PIK3R1 GeneProduct ncbigene:427171
MAP3K2 GeneProduct ncbigene:424225
GRB14 GeneProduct ncbigene:424183
GRB2 GeneProduct ncbigene:386572
GRB10 GeneProduct ncbigene:420948
MAP3K3 GeneProduct ncbigene:419954
SOS1 GeneProduct ncbigene:425964
PIK3R2 GeneProduct ncbigene:771142
SHC1 GeneProduct ncbigene:395934
PIK3R3 GeneProduct ncbigene:429096
PIK3CA GeneProduct ncbigene:424971
PIK3CB GeneProduct ncbigene:424826
PIK3CD GeneProduct ncbigene:419444
PIK3CG GeneProduct ncbigene:417706
GAB1 GeneProduct ncbigene:422456
GAB2 GeneProduct ncbigene:419027
JAK1 GeneProduct ncbigene:395681
RCJMB04_17i9 GeneProduct ncbigene:424044
JAK2 GeneProduct ncbigene:374199
STAT3 GeneProduct ncbigene:420027
STAT5B GeneProduct ncbigene:395556
MAP2K1 GeneProduct ncbigene:415549
RCJMB04_5a10 GeneProduct ncbigene:417430
MAP3K1 GeneProduct ncbigene:427144
PRKCZ GeneProduct ncbigene:419399
RCJMB04_12k21 GeneProduct ncbigene:423302
RCJMB04_16p24 GeneProduct ncbigene:424991
PRKCB GeneProduct ncbigene:416567
MAP2K2 GeneProduct ncbigene:396349
RCJMB04_8f10 GeneProduct ncbigene:416496
RCJMB04_36h7 GeneProduct ncbigene:415557
MAP3K4 GeneProduct ncbigene:421579
VAV3 GeneProduct ncbigene:373939
VAV2 GeneProduct ncbigene:373938
MAPK1 GeneProduct ncbigene:373953
ELK4 GeneProduct ncbigene:419832
MAPK8 GeneProduct ncbigene:423778
PTPRR GeneProduct ncbigene:771985
GJA1 GeneProduct ncbigene:395278
YWHAB GeneProduct ncbigene:419190
WNK1 GeneProduct ncbigene:427925
EGFR GeneProduct ncbigene:396494
KRT8 GeneProduct ncbigene:426896
EPPK1 GeneProduct ncbigene:429489
PTPN12 GeneProduct ncbigene:417725
STAT3 GeneProduct ncbigene:420027
PLSCR1 GeneProduct ncbigene:424883
ERRFI1 GeneProduct ncbigene:419364
CBLB GeneProduct ncbigene:418406
PLD1 GeneProduct ncbigene:424986
RCJMB04_5a10 GeneProduct ncbigene:417430
RCJMB04_1d5 GeneProduct ncbigene:424633
EPS8 GeneProduct ncbigene:418174
HTT GeneProduct ncbigene:422878
PIK3C2B GeneProduct ncbigene:419822
SH3BGRL GeneProduct ncbigene:422277
CSK GeneProduct ncbigene:396396
REPS2 GeneProduct ncbigene:418617
RCJMB04_4o17 GeneProduct ncbigene:429466
RALB GeneProduct ncbigene:424237
REPS1 GeneProduct ncbigene:421678
TNK2 GeneProduct ncbigene:431014
RCJMB04_25c5 GeneProduct ncbigene:420489
SOS2 GeneProduct ncbigene:423572
DNM1 GeneProduct ncbigene:417217
SH3GL3 GeneProduct ncbigene:395201
CDC42 GeneProduct ncbigene:395917
SPRY2 GeneProduct ncbigene:395584
FOS GeneProduct ncbigene:396512
CEBPA GeneProduct ncbigene:427549
MYC GeneProduct ncbigene:420332
CEBPB GeneProduct ncbigene:396185
PEBP1 GeneProduct ncbigene:416990
KLF11 GeneProduct ncbigene:421934
SIN3A GeneProduct ncbigene:415307
TGIF1 GeneProduct ncbigene:396339
HDAC1 GeneProduct ncbigene:373961
SH3KBP1 GeneProduct ncbigene:418608
SH3GL2 GeneProduct ncbigene:395203
JUN GeneProduct ncbigene:424673
SP1 GeneProduct ncbigene:395303
AKT1 GeneProduct ncbigene:395928
PTPN5 GeneProduct ncbigene:423085
SNCA GeneProduct ncbigene:395393
RPS6KA1 GeneProduct ncbigene:386579
RPS6KA3 GeneProduct ncbigene:418605
RPS6KA2 GeneProduct ncbigene:421570
WASL GeneProduct ncbigene:417750
EEF1A1 GeneProduct ncbigene:373963
APPL1 GeneProduct ncbigene:416002
APPL2 GeneProduct ncbigene:418075
EPS15L1 GeneProduct ncbigene:420147
HIP1 GeneProduct ncbigene:770683
RFXANK GeneProduct ncbigene:426623
MAPK14 GeneProduct ncbigene:421183
TNIP1 GeneProduct ncbigene:396235
EGFR GeneProduct ncbigene:396494
EGFR GeneProduct ncbigene:396494
RBBP7 GeneProduct ncbigene:395390
DDEF1 GeneProduct ncbigene:428385
STXBP1 GeneProduct ncbigene:404293
RCJMB04_21j12 GeneProduct ncbigene:428852
PKN2 GeneProduct ncbigene:424519
PAK1 GeneProduct ncbigene:419083
SH2D3C GeneProduct ncbigene:417225
BCAR1 GeneProduct ncbigene:415691
CASP9 GeneProduct ncbigene:426970
RPS6KA5 GeneProduct ncbigene:423408
SMAD2 GeneProduct ncbigene:395247
SMAD3 GeneProduct ncbigene:395132
SMAD2 GeneProduct ncbigene:395247
SMAD3 GeneProduct ncbigene:395132
ATF1 GeneProduct ncbigene:426873
CREB1 GeneProduct ncbigene:395099
FOXO1A GeneProduct ncbigene:374231
PXN GeneProduct ncbigene:395832
ELF3 GeneProduct ncbigene:421177
HAT1 GeneProduct ncbigene:374037
CAMK2A GeneProduct ncbigene:374175
ITCH GeneProduct ncbigene:419145
MCF2 GeneProduct ncbigene:422253
ELF3 GeneProduct ncbigene:421177
RPS6KA3 GeneProduct ncbigene:418605
MAP3K2 GeneProduct ncbigene:424225
FOXO1A GeneProduct ncbigene:374231
RCJMB04_1d5 GeneProduct ncbigene:424633
EEF1A1 GeneProduct ncbigene:373963
RCJMB04_17i9 GeneProduct ncbigene:424044
STAT3 GeneProduct ncbigene:420027
ZNF259 GeneProduct ncbigene:428256
SPRY2 GeneProduct ncbigene:395584
PLCG2 GeneProduct ncbigene:415805
PLCG2 GeneProduct ncbigene:415805
PTPN6 GeneProduct ncbigene:427947
RAF1 GeneProduct ncbigene:396245
GAB1 GeneProduct ncbigene:422456
SHC1 GeneProduct ncbigene:395934
PLD1 GeneProduct ncbigene:424986
BCAR1 GeneProduct ncbigene:415691
SH2D3C GeneProduct ncbigene:417225
STXBP1 GeneProduct ncbigene:404293
APPL1 GeneProduct ncbigene:416002
APPL1 GeneProduct ncbigene:416002
APPL2 GeneProduct ncbigene:418075
RCJMB04_17i9 GeneProduct ncbigene:424044
SRC GeneProduct ncbigene:396442
CBL GeneProduct ncbigene:374038
CRK GeneProduct ncbigene:417553
CRKL GeneProduct ncbigene:416939
RAC1 GeneProduct ncbigene:395871
PTK2B GeneProduct ncbigene:421998
CAV1 GeneProduct ncbigene:373996
CAV2 GeneProduct ncbigene:417772
RCJMB04_13d16 GeneProduct ncbigene:418727
GIT1 GeneProduct ncbigene:374176
RGS16 GeneProduct ncbigene:424409
SOCS1 GeneProduct ncbigene:416630
SOCS3 GeneProduct ncbigene:395299
INPPL1 GeneProduct ncbigene:428692
RAB5A GeneProduct ncbigene:420649
USP6NL GeneProduct ncbigene:423110
ARF4 GeneProduct ncbigene:769725
ZNF259 GeneProduct ncbigene:428256
RIPK1 GeneProduct ncbigene:378921
MAP3K14 GeneProduct ncbigene:419964
RALGDS GeneProduct ncbigene:427758
RASA1 GeneProduct ncbigene:427327
PRKAR1A GeneProduct ncbigene:417438
PTPN6 GeneProduct ncbigene:427947
PTPN11 GeneProduct ncbigene:395815
MAPK1 GeneProduct ncbigene:373953
MAP2K1 GeneProduct ncbigene:415549
DUSP1 GeneProduct ncbigene:374192
DUSP1 GeneProduct ncbigene:374192
ARF4 GeneProduct ncbigene:769725
ARF4 GeneProduct ncbigene:769725
EGF GeneProduct ncbigene:408035
EGF GeneProduct ncbigene:408035
SH3GL2 GeneProduct ncbigene:395203
EGFR GeneProduct ncbigene:396494

References

  1. Control of MAPK signalling: from complexity to what really matters. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV. Oncogene. 2005 Aug 25;24(36):5533–42. PubMed Europe PMC Scholia