Mitochondrial complex I inhibition leading to chemical-induced Fanconi syndrome (WP4944)

Homo sapiens

This pathway is a meta-pathway that represents an updated version of the Adverse Outcome Pathway 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome ( All Key Events are present as Key Event nodes, with their corresponding molecular pathways as pathway nodes.


Marvin Martens , Egon Willighagen , Eric Weitz , Finterly Hu , and Martina Summer-Kutmon


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Homo sapiens


Adverse Outcome Pathways


Pathway Ontology

altered metabolic pathway disease pathway

Disease Ontology

Fanconi syndrome


Label Type Compact URI Comment
Deguelin Metabolite chebi:4357